The DOI matches its OpenAlex record; 2 of the 2 references it cites were found in a registry or an index.
Genetic testing for children and adolescents. Who decides?
Abstract
In the future there is likely to be a large array of DNA-based tests to diagnose single-gene disorders and to identify predispositions to genetically influenced disorders. This article focuses on ethical, legal, and psychological implications of testing healthy children and adolescents for such disorders. Testing may offer medical or psychological benefits but may harm parent-child bonds or the child's self-concept. Clinicians may encounter situations where they must weigh the child's or adolescent's wishes against wishes of parents. We examine the legal history and current status of minors as health care consumers; psychosocial research on their maturity to make choices; impact of testing on intrafamilial relationships; views of national commissions on appropriate ages of assent and full informed consent; ethical and legal requirements for competence in children and adolescents; and disclosure of genetic information. We propose guidelines for predictive genetic testing and counseling of children and discuss risks and benefits of testing.
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Citations
Cites
Principles of Biomedical Ethics
(2012) · Thieves of Virtue · doi:10.7551/mitpress/9079.003.0009 · Cited by 13,453
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366
Cited by
Robson, M. E., Bradbury, A. R., Arun, B., Domchek, S. M., Ford, J. M., Hampel, H. L., Lipkin, S. M., Syngal, S., Wollins, D. S., & Lindor, N. M. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.63.0996 · Cited by 934
The Use and Interpretation of Commercial APC Gene Testing for Familial Adenomatous Polyposis
Giardiello, F. M., Brensinger, J. D., Petersen, G. M., Luce, M. C., Hylind, L. M., Bacon, J. A., Booker, S. V., Parker, R. D., & Hamilton, S. R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199703203361202 · Cited by 498
Children's Competence for Assent and Consent: A Review of Empirical Findings
Miller, V. A., Drotar, D., & Kodish, E. (2004) · Ethics & Behavior · doi:10.1207/s15327019eb1403_3 · Cited by 186
Efficacy of a targeted genetic screening program for adolescents.
(1996) · PubMed Central · Cited by 18
Metadata
- Authors
- Wertz, D. C.
- Venue
- JAMA
- Publisher
- American Medical Association
- Published
- 1994-09-21
- Volume
- 272
- Issue
- 11
- Pages
- 875-881
- ISSN
- 0002-9955 (ISSN-L)
- OpenAlex
- W4233203929
- Cited by
- 279
- References
- 2
- FWCI
- 21.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wertz, D. C. (1994). Genetic testing for children and adolescents. Who decides? JAMA. https://doi.org/10.1001/jama.272.11.875
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
