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Implications of the Human Genome Project for Medical Science
Abstract
The year 2000 marked both the start of the new millennium and the announcement that the vast majority of the human genome had been sequenced. Much work remains to understand how this "instruction book for human biology" carries out its multitudes of functions. But the consequences for the practice of medicine are likely to be profound. Genetic prediction of individual risks of disease and responsiveness to drugs will reach the medical mainstream in the next decade or so. The development of designer drugs, based on a genomic approach to targeting molecular pathways that are disrupted in disease, will follow soon after. Potential misuses of genetic information, such as discrimination in obtaining health insurance and in the workplace, will need to be dealt with swiftly and effectively. Genomic medicine holds the ultimate promise of revolutionizing the diagnosis and treatment of many illnesses.
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Citations
Cited by
Ashley, E. A. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.86 · Cited by 1,116
Wooley, J. C., Godzik, A., & Friedberg, I. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000667 · Cited by 688
Dunbar, S. A. (2006) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.06.023 · Cited by 608
Geneticization of Deviant Behavior and Consequences for Stigma: The Case of Mental Illness
Phelan, J. C. (2005) · Journal of Health and Social Behavior · doi:10.1177/002214650504600401 · Cited by 567
Reconsidering the family history in primary care
Rich, E. C., Burke, W., Heaton, C. J., Haga, S., Pinsky, L., Short, M. P., & Acheson, L. (2004) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2004.30401.x · Cited by 347
Metadata
- Authors
- Collins, F. S.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2001-02-07
- Volume
- 285
- Issue
- 5
- Pages
- 540
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2141750609
- Cited by
- 838
- References
- 0
- FWCI
- 33.99
- Type
- journal article
- Language
- en
- Open access
- closed
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