The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Association of Long QT Syndrome Loci and Cardiac Events Among Patients Treated With β-Blockers
Abstract
CONTEXT: Data on the efficacy of beta-blockers in the 3 most common genetic long QT syndrome (LQTS) loci are limited. OBJECTIVE: To describe and assess outcome in a large systematically genotyped population of beta-blocker-treated LQTS patients. DESIGN, SETTING, AND PATIENTS: Consecutive LQTS-genotyped patients (n = 335) in Italy treated with beta-blockers for an average of 5 years. MAIN OUTCOME MEASURES: Cardiac events (syncope, ventricular tachycardia/torsades de pointes, cardiac arrest, and sudden cardiac death) while patients received beta-blocker therapy according to genotype. RESULTS: Cardiac events among patients receiving beta-blocker therapy occurred in 19 of 187 (10%) LQT1 patients, 27 of 120 (23%) LQT2 patients, and 9 of 28 (32%) LQT3 patients (P<.001). The risk of cardiac events was higher among LQT2 (adjusted relative risk, 2.81; 95% confidence interval [CI], 1.50-5.27; P =.001) and LQT3 (adjusted relative risk, 4.00; 95% CI, 2.45-8.03; P<.001) patients than among LQT1 patients, suggesting inadequate protection from beta-blocker therapy. Other important predictors of risk were a QT interval corrected for heart rate that was more than 500 ms in patients receiving therapy (adjusted relative risk, 2.01; 95% CI, 1.16-3.51; P =.01) and occurrence of a first cardiac event before the age of 7 years (adjusted RR, 4.34; 95% CI, 2.35-8.03; P<.001). CONCLUSION: Among patients with genetic LQTS treated with beta-blockers, there is a high rate of cardiac events, particularly among patients with LQT2 and LQT3 genotypes.
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Schwartz, P. J., Priori, S. G., Spazzolini, C., Moss, A. J., Vincent, G. M., Napolitano, C., Denjoy, I., Guicheney, P., Breithardt, G., Keating, M. T., et al. (2001) · Circulation · doi:10.1161/01.cir.103.1.89 · Cited by 1,779
Self-citationRisk Stratification in the Long-QT Syndrome
Priori, S. G., Schwartz, P. J., Napolitano, C., Bloise, R., Ronchetti, E., Grillo, M., Vicentini, A., Spazzolini, C., Nastoli, J., Bottelli, G., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022147 · Cited by 1,459
Self-citationMolecular and Cellular Mechanisms of Cardiac Arrhythmias
Keating, M. T., & Sanguinetti, M. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00243-4 · Cited by 1,001
Task Force on Sudden Cardiac Death of the European Society of Cardiology
Priori, S. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2824 · Cited by 903
Self-citationEffectiveness and Limitations of β-Blocker Therapy in Congenital Long-QT Syndrome
Moss, A. J., Zareba, W., Hall, W. J., Schwartz, P. J., Crampton, R. S., Benhorin, J., Vincent, G. M., Locati, E. H., Priori, S. G., Napolitano, C., et al. (2000) · Circulation · doi:10.1161/01.cir.101.6.616 · Cited by 841
Self-citationA NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN.
Ward, O. C. (1964) · PubMed · Cited by 826
Schwartz, P. J. (1997) · Current Problems in Cardiology · doi:10.1016/s0146-2806(97)80009-6 · Cited by 693
Schwartz, P. J., Priori, S. G., Cerrone, M., Spazzolini, C., Odero, A., Napolitano, C., Bloise, R., De Ferrari, G. M., Klersy, C., Moss, A. J., et al. (2004) · Circulation · doi:10.1161/01.cir.0000125523.14403.1e · Cited by 686
Self-citationSchwartz, P. J., & Priori, S. G. (1998) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.1998.tb00031.x · Cited by 130
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Cited by
Priori, S. G., Blomström-Lundqvist, C., Mazzanti, A., Blom, N., Borggrefe, M., Camm, J., Elliott, P. M., Fitzsimons, D., Hatala, R., Hindricks, G., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv316 · Cited by 3,893
Self-citationACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities
Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N. A. M., Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.032 · Cited by 2,546
Priori, S. G., Wilde, A. A., Horie, M., Cho, Y., Behr, E. R., Berul, C., Blom, N., Brugada, J., Chiang, C.-E., Huikuri, H., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.05.014 · Cited by 1,942
Self-citationLong-QT Syndrome: From Genetics to Management
Schwartz, P. J., Crotti, L., & Insolia, R. (2012) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.111.962019 · Cited by 659
Priori, S. G., Wilde, A. A., Horie, M., Cho, Y., Behr, E. R., Berul, C., Blom, N., Brugada, J., Chiang, C.-E., Huikuri, H., et al. (2013) · EP Europace · doi:10.1093/europace/eut272 · Cited by 624
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Metadata
- Authors
- Priori, S. G.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2004-09-15
- Volume
- 292
- Issue
- 11
- Pages
- 1341
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2156937709
- Cited by
- 601
- References
- 9
- FWCI
- 21.68
- Type
- journal article
- Language
- en
- Open access
- closed
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