The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Stem Cell Mobilization by Granulocyte Colony-Stimulating Factor in Patients With Acute Myocardial Infarction<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
Abstract
CONTEXT: Experimental studies and early phase clinical trials suggest that transplantation of blood-derived or bone marrow-derived stem cells may improve cardiac regeneration and neovascularization after acute myocardial infarction. Granulocyte colony-stimulating factor (G-CSF) induces mobilization of bone marrow stem cells. OBJECTIVE: To assess the value of stem cell mobilization by G-CSF therapy in patients with acute myocardial infarction. DESIGN, SETTING, AND PATIENTS: Randomized, double-blind, placebo-controlled trial of patients diagnosed with ST-segment elevation acute myocardial infarction who had successful reperfusion by percutaneous coronary intervention within 12 hours after onset of symptoms in Germany between February 24, 2004, and February 2, 2005. INTERVENTIONS: Patients were randomly assigned to receive subcutaneously either a daily dose of 10 microg/kg of G-CSF or placebo for 5 days. MAIN OUTCOME MEASURES: The primary end point was reduction of left ventricular infarct size according to technetium Tc 99m sestamibi scintigraphy performed at baseline and at 4 to 6 months after randomization. Secondary end points included improvement of left ventricular ejection fraction measured by magnetic resonance imaging and the incidence of angiographic restenosis. RESULTS: Of the 114 patients, 56 were assigned to receive treatment with G-CSF and 58 were assigned to receive placebo. Treatment with G-CSF produced a significant mobilization of stem cells. Between baseline and follow-up, left ventricular infarct size according to scintigraphy was reduced by a mean (SD) of 6.2% (9.1%) in the G-CSF group and 4.9% (8.9%) in the placebo group (P = .56) and left ventricular ejection fraction was improved by 0.5% (3.8%) in the G-CSF group and 2.0% (4.9%) in the placebo group (P = .14). Angiographic restenosis occurred in 19 (35.2%) of 54 patients in the G-CSF group and in 17 (30.9%) of 55 patients in the placebo group (P = .79). The most common adverse event among patients assigned to G-CSF was mild to moderate bone pain and muscle discomfort. CONCLUSION: Stem cell mobilization by G-CSF therapy in patients with acute myocardial infarction and successful mechanical reperfusion has no influence on infarct size, left ventricular function, or coronary restenosis. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT00126100.
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Kocher, A. A., Schuster, M. D., Szabolcs, M. J., Takuma, S., Burkhoff, D., Wang, J., Homma, S., Edwards, N. M., & Itescu, S. (2001) · Nature Medicine · doi:10.1038/86498 · Cited by 2,540
Assmus, B., Schächinger, V., Teupe, C., Britten, M., Lehmann, R., Döbert, N., Grünwald, F., Aicher, A., Urbich, C., Martin, H., et al. (2002) · Circulation · doi:10.1161/01.cir.0000043246.74879.cd · Cited by 2,201
Wollert, K. C., Meyer, G. P., Lotz, J., Ringes Lichtenberg, S., Lippolt, P., Breidenbach, C., Fichtner, S., Korte, T., Hornig, B., Messinger, D., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16626-9 · Cited by 2,191
Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
Murry, C. E., Soonpaa, M. H., Reinecke, H., Nakajima, H., Nakajima, H. O., Rubart, M., Pasumarthi, K. B. S., Ismail Virag, J., Bartelmez, S. H., Poppa, V., et al. (2004) · Nature · doi:10.1038/nature02446 · Cited by 2,154
Mobilized bone marrow cells repair the infarcted heart, improving function and survival
Orlic, D., Kajstura, J., Chimenti, S., Limana, F., Jakoniuk, I., Quaini, F., Nadal-Ginard, B., Bodine, D. M., Leri, A., & Anversa, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181177898 · Cited by 2,086
Strauer, B. E., Brehm, M., Zeus, T., Köstering, M., Hernandez, A., Sorg, R. V., Kögler, G., & Wernet, P. (2002) · Circulation · doi:10.1161/01.cir.0000034046.87607.1c · Cited by 2,067
Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
Balsam, L. B., Wagers, A. J., Christensen, J. L., Kofidis, T., Weissman, I. L., & Robbins, R. C. (2004) · Nature · doi:10.1038/nature02460 · Cited by 1,736
Evidence That Human Cardiac Myocytes Divide after Myocardial Infarction
Beltrami, A. P., Urbanek, K., Kajstura, J., Yan, S.-M., Finato, N., Bussani, R., Nadal-Ginard, B., Silvestri, F., Leri, A., Beltrami, C. A., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106073442303 · Cited by 1,429
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
Laugwitz, K.-L., Moretti, A., Lam, J., Gruber, P., Chen, Y., Woodard, S., Lin, L.-Z., Cai, C.-L., Lu, M. M., Reth, M., et al. (2005) · Nature · doi:10.1038/nature03215 · Cited by 1,304
Janssens, S., Dubois, C., Bogaert, J., Theunissen, K., Deroose, C., Desmet, W., Kalantzi, M., Herbots, L., Sinnaeve, P., Dens, J., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(05)67861-0 · Cited by 1,294
Cited by
Potential risks of bone marrow cell transplantation into infarcted hearts
Breitbach, M., Bostani, T., Roell, W., Xia, Y., Dewald, O., Nygren, J. M., Fries, J. W. U., Tiemann, K., Bohlen, H., Hescheler, J., et al. (2007) · Blood · doi:10.1182/blood-2006-12-063412 · Cited by 623
Vascular Inflammation and Repair
Inoue, T., Croce, K., Morooka, T., Sakuma, M., Node, K., & Simon, D. I. (2011) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2011.05.025 · Cited by 480
Zaruba, M.-M., Theiss, H. D., Vallaster, M., Mehl, U., Brunner, S., David, R., Fischer, R., Krieg, L., Hirsch, E., Huber, B., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.02.013 · Cited by 301
Differential Mobilization of Subsets of Progenitor Cells from the Bone Marrow
Pitchford, S. C., Furze, R. C., Jones, C. P., Wengner, A. M., & Rankin, S. M. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.10.017 · Cited by 277
Hinkel, R., El-Aouni, C., Olson, T., Horstkotte, J., Mayer, S., Müller;, S., Willhauck, M., Spitzweg, C., Gildehaus, F.-J., Münzing, W., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.758904 · Cited by 151
Metadata
- Authors
- Zohlnhöfer, D.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2006-03-01
- Volume
- 295
- Issue
- 9
- Pages
- 1003
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2112174413
- Cited by
- 431
- References
- 40
- FWCI
- 34.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zohlnhöfer, D. (2006). Stem Cell Mobilization by Granulocyte Colony-Stimulating Factor in Patients With Acute Myocardial Infarction<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>. JAMA. https://doi.org/10.1001/jama.295.9.1003
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