CoChat
Sign Up
Cited by 340Substance Abuse Treatment and OutcomesAlcohol Consumption and Health EffectsOpioid Use Disorder Treatment

The DOI matches its Crossref record, with a small difference in title or year; 41 of the 41 references it cites were found in a registry or an index.

Gabapentin Treatment for Alcohol Dependence: A Randomized Clinical Trial

Open access
Mason, Barbara J., Quello, Susan, Goodell, Vivian, Shadan, Farhad, Kyle, Mark, Begovic, Adnan·2014·JAMA Internal Medicine
DOI 10.1001/jamainternmed.2013.11950PMC PMC3920987
Open this paper in CoChat — free account

Abstract

IMPORTANCE: Approved medications for alcohol dependence are prescribed for less than 9% of US alcoholics. OBJECTIVE: To determine if gabapentin, a widely prescribed generic calcium channel/γ-aminobutyric acid-modulating medication, increases rates of sustained abstinence and no heavy drinking and decreases alcohol-related insomnia, dysphoria, and craving, in a dose-dependent manner. DESIGN, PARTICIPANTS AND SETTING: A 12-week, double-blind, placebo-controlled, randomized dose-ranging trial of 150 men and women older than 18 years with current alcohol dependence, conducted from 2004 through 2010 at a single-site, outpatient clinical research facility adjoining a general medical hospital. INTERVENTIONS: Oral gabapentin (dosages of 0 [placebo], 900 mg, or 1800 mg/d) and concomitant manual-guided counseling. MAIN OUTCOMES AND MEASURES: Rates of complete abstinence and no heavy drinking (coprimary) and changes in mood, sleep, and craving (secondary) over the 12-week study. RESULTS Gabapentin significantly improved the rates of abstinence and no heavy drinking. The abstinence rate was 4.1% (95% CI, 1.1%-13.7%) in the placebo group, 11.1% (95% CI, 5.2%-22.2%) in the 900-mg group, and 17.0% (95% CI, 8.9%-30.1%) in the 1800-mg group (P = .04 for linear dose effect; number needed to treat [NNT] = 8 for 1800 mg). The no heavy drinking rate was 22.5% (95% CI, 13.6%-37.2%) in the placebo group, 29.6% (95% CI, 19.1%-42.8%) in the 900-mg group, and 44.7% (95% CI, 31.4%-58.8%) in the 1800-mg group (P = .02 for linear dose effect; NNT = 5 for 1800 mg). Similar linear dose effects were obtained with measures of mood (F2 = 7.37; P = .001), sleep (F2 = 136; P < .001), and craving (F2 = 3.56; P = .03). There were no serious drug-related adverse events, and terminations owing to adverse events (9 of 150 participants), time in the study (mean [SD], 9.1 [3.8] weeks), and rate of study completion (85 of 150 participants) did not differ among groups. CONCLUSIONS AND RELEVANCE: Gabapentin (particularly the 1800-mg dosage) was effective in treating alcohol dependence and relapse-related symptoms of insomnia, dysphoria, and craving, with a favorable safety profile. Increased implementation of pharmacological treatment of alcohol dependence in primary care may be a major benefit of gabapentin as a treatment option for alcohol dependence. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00391716.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1001/jamainternmed.2013.11950

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 41 references

Research works printed but not linked: 3

  1. [23]First Michael B. Spitzer Robert L Gibbon Miriam Williams Janet B.W. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P) 11 2002 Biometrics Research, New York State Psychiatric Institute New York
  2. [33]FDA Medical Review of Vivitrol: 21-897 2006 U.S. Government Rockville, MD
  3. [40]Norusis MJ SPSS Statistics 17.0 Advanced Statistical Procedures Companion 2008 Prentice Hall Inc. Upper Saddle River, NJ

Cited by

Sorted by citations

Items 201–300 of 340

Related

See all

Metadata

Authors
Mason, B. J., Quello, S., Goodell, V., Shadan, F., Kyle, M., & Begovic, A.
Affiliations
  • Scripps Research Institute (US)
  • The Scripps Research Institute, Pearson Center for Alcoholism and Addiction Research, La Jolla, California
Corresponding author
Mason, Barbara J.
Venue
JAMA Internal Medicine
Publisher
American Medical Association (AMA)
Published
2014-01-01
Volume
174
Issue
1
Pages
70
ISSN
2168-6106 (ISSN-L)
DOI
10.1001/jamainternmed.2013.11950
PMC
PMC3920987
OpenAlex
W2159492208
Cited by
340
References
41
Citations by year
2026: 14 · 2025: 16 · 2024: 23 · 2023: 24 · 2022: 25 · 2021: 28 · 2020: 30 · 2019: 41 · 2018: 32 · 2017: 24 · 2016: 27 · 2015: 34 · 2014: 20
FWCI
20.20
Type
journal article
Language
en
Open access
Locations
  • JAMA Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Alcohol Abuse and Alcoholism (R37AA014028, R01AA014028)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords
gabapentin, alcoholism, sustained abstinence, heavy drinking, alcohol craving, dysphoria, mood, dose-response relationship, calcium channel modulators, number needed to treat, medication adherence, relapse prevention
MeSH terms
Gabapentin, Adult, Ethanol, Alcoholism, Amines, Central Nervous System Depressants, Cyclohexanecarboxylic Acids, Double-Blind Method, Female, gamma-Aminobutyric Acid, Humans, Male, Middle Aged, Substance Withdrawal Syndrome, Treatment Outcome, GABA Modulators, Alcohol Abstinence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review