Association Between Implementation of the Severe Sepsis and Septic Shock Early Management Bundle Performance Measure and Outcomes in Patients With Suspected Sepsis in US Hospitals

Rhee, Chanu; Yu, Tingting; Wang, Rui; Kadri, Sameer S.; Fram, David; Chen, Huai-Chun; Klompas, Michael; CDC Prevention Epicenters Program

doi:10.1001/jamanetworkopen.2021.38596

Association Between Implementation of the Severe Sepsis and Septic Shock Early Management Bundle Performance Measure and Outcomes in Patients With Suspected Sepsis in US Hospitals

Key Points Question Was implementation of the CMS Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) in October 2015 associated with improvements in sepsis-associated mortality? Findings In this cohort study of 117 510 adult patients admitted to 114 US hospitals with clinical evidence…