Jarisch-Herxheimer Reaction After Benzathine Penicillin G Treatment in Adults With Early Syphilis

Dionne, Jodie A.; Zhu, Chunming; Mejia-Galvis, Jorge; Workowski, Kimberly; Batteiger, Teresa A.; Dombrowski, Julia C.; Mayer, Kenneth H.; McNeil, Candice J.; Seña, Arlene C.; Taylor, Stephanie; Wiesenfeld, Harold C.; Hamill, Matthew M.; Perlowski, Charlotte; Hook, Edward W.

doi:10.1001/jamanetworkopen.2024.59490

Jarisch-Herxheimer Reaction After Benzathine Penicillin G Treatment in Adults With Early Syphilis

Importance Syphilis rates have been increasing in the US for the past decade. The incidence of the Jarisch-Herxheimer reaction (JHR) after penicillin treatment for early syphilis is reported to range from 8% to 56%. Objectives To prospectively assess the incidence of JHR signs and symptoms among …