The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Predicting Hematoma Expansion After Primary Intracerebral Hemorrhage
Open accessAbstract
IMPORTANCE: Many clinical trials focus on restricting hematoma expansion following acute intracerebral hemorrhage (ICH), but selecting those patients at highest risk of hematoma expansion is challenging. OBJECTIVE: To develop a prediction score for hematoma expansion in patients with primary ICH. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study at 2 urban academic medical centers among patients having primary ICH with available baseline and follow-up computed tomography for volumetric analysis (817 patients in the development cohort and 195 patients in the independent validation cohort). MAIN OUTCOMES AND MEASURES: Hematoma expansion was assessed using semiautomated software and was defined as more than 6 mL or 33% growth. Covariates were tested for association with hematoma expansion using univariate and multivariable logistic regression. A 9-point prediction score was derived based on the regression estimates and was subsequently tested in the independent validation cohort. RESULTS: Hematoma expansion occurred in 156 patients (19.1%). In multivariable analysis, predictors of expansion were as follows: warfarin sodium use, the computed tomography angiography spot sign, and shorter time to computed tomography (≤ 6 vs >6 hours) (P < .001 for all), as well as baseline ICH volume (<30 [reference], 30-60 [P = .03], and >60 [P = .005] mL). The incidence of hematoma expansion steadily increased with higher scores. In the independent validation cohort (n = 195), our prediction score performed well and showed strong association with hematoma expansion (odds ratio, 4.59; P < .001 for a high vs low score). The C statistics for the score were 0.72 for the development cohort and 0.77 for the independent validation cohort. CONCLUSIONS AND RELEVANCE: A 9-point prediction score for hematoma expansion was developed and independently validated. The results open a path for individualized treatment and trial design in ICH aimed at patients at highest risk of hematoma expansion with maximum potential for therapeutic benefit.
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Volume of intracerebral hemorrhage. A powerful and easy-to-use predictor of 30-day mortality.
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Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage
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Early Hemorrhage Growth in Patients With Intracerebral Hemorrhage
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Efficacy and Safety of Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage
Mayer, S. A., Brun, N. C., Begtrup, K., Broderick, J., Davis, S., Diringer, M. N., Skolnick, B. E., & Steiner, T. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707534 · Cited by 1,255
Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage
Davis, S. M., Broderick, J., Hennerici, M., Brun, N. C., Diringer, M. N., Mayer, S. A., Begtrup, K., & Steiner, T. (2006) · Neurology · doi:10.1212/01.wnl.0000208408.98482.99 · Cited by 1,168
Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage
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Cited by
Do Clinicians Overestimate the Severity of Intracerebral Hemorrhage?
Tilling, E. J., El Tawil, S., & Muir, K. W. (2019) · Stroke · doi:10.1161/strokeaha.118.022606 · Cited by 1,120
Reversal strategies for vitamin Kantagonists in acute intracerebral hemorrhage
Parry‐Jones, A. R., Di Napoli, M., Goldstein, J. N., Schreuder, F. H. B. M., Tetri, S., Tatlisumak, T., Yan, B., van Nieuwenhuizen, K. M., Dequatre‐Ponchelle, N., Lee‐Archer, M., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24416 · Cited by 90
Self-citation
Metadata
- Authors
- Brouwers, H. B., Chang, Y., Falcone, G. J., Cai, X., Ayres, A. M., Battey, T. W. K., Vashkevich, A., McNamara, K. A., Valant, V., Schwab, K., Orzell, S. C., Bresette, L. M., Feske, S. K., Rost, N. S., Romero, J. M., Viswanathan, A., Chou, S. H.-Y., Greenberg, S. M., Rosand, J., & Goldstein, J. N.
- Venue
- JAMA Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2014-02-01
- Volume
- 71
- Issue
- 2
- Pages
- 158
- ISSN
- 2168-6149 (ISSN-L)
- OpenAlex
- W1966921182
- Cited by
- 370
- References
- 33
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Brouwers, H. B., Chang, Y., Falcone, G. J., Cai, X., Ayres, A. M., Battey, T. W. K., Vashkevich, A., McNamara, K. A., Valant, V., Schwab, K., Orzell, S. C., Bresette, L. M., Feske, S. K., Rost, N. S., Romero, J. M., Viswanathan, A., Chou, S. H.-Y., Greenberg, S. M., Rosand, J., & Goldstein, J. N. (2014). Predicting Hematoma Expansion After Primary Intracerebral Hemorrhage. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2013.5433
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