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Estimating the Risk of Attempted Suicide Among Sexual Minority Youths: A Systematic Review and Meta-analysis
Open accessAbstract
Importance: Suicide is the second-leading cause of death among adolescents. Sexual minority individuals are at a higher risk of suicide and attempted suicide, but a precise and systematic evaluation of this risk among sexual minority youths has not been documented to our knowledge. Objective: To examine the risk of attempted suicide among sexual minority adolescents, differentiating for each sexual minority group. Data Sources: Electronic databases (PubMed, Embase, and PsycINFO) were searched for articles published through April 30, 2017, with the following search terms: heterosexual, homosexual, bisexual, transgender, adolescents, teens, and attempted suicide. Study Selection: Studies that reported attempted suicide in sexual minority adolescents compared with heterosexual peers were included. Thirty-five studies satisfied criteria for inclusion of 764 records identified. Data Extraction and Synthesis: Pooled analyses were based on odds ratios (ORs), with relevant 95% CIs, weighting each study with inverse variance models with random effects. Risk of publication bias and analysis of heterogeneity through univariable and multivariable meta-regressions were also rated. Main Outcomes and Measures: The evaluation of increased odds of attempted suicide among sexual minority youths compared with heterosexual peers. Results: Thirty-five studies reported in 22 articles that involved a total of 2 378 987 heterosexual and 113 468 sexual minority adolescents (age range, 12-20 years) were included in the analysis. Sexual minority youths were generally at higher risk of attempted suicide (OR, 3.50; 95% CI, 2.98-4.12; c2 = 3074.01; P < .001; I2 = 99%). If estimated in each sexual minority group, the OR was 3.71 in the homosexual group (95% CI, 3.15-4.37; c2 = 825.20; P < .001; I2 = 97%) and 4.87 in the bisexual group (95% CI, 4.76-4.98; c2 = 980.02; P < .001; I2 = 98%); transgender youths were described as an individual group in only 1 study, which reported an OR of 5.87 (95% CI, 3.51-9.82). Meta-regressions weighted for the study weight highlighted that the presence of young participants (12 years old) was associated with heterogeneity in the bisexual group, whereas the year of sampling was associated with heterogeneity in the whole group when combined with other covariates. Conclusions and Relevance: Our findings suggest that youths with nonheterosexual identity have a significantly higher risk of life-threatening behavior compared with their heterosexual peers. Public awareness is important, and a careful evaluation of supportive strategies (eg, support programs, counseling, and destigmatizing efforts) should be part of education and public health planning.
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“The prevalence of mental ill health and suicidal risk is substantially higher in LGBTIQA+ and gender-diverse young people compared with their non-LGBTIQA+ and non-gender-diverse peers. 155-157”
From The Lancet Psychiatry Commission on youth mental health (2024) · cites this paper as [155]
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Metadata
- Authors
- di Giacomo, E., Krausz, M., Colmegna, F., Aspesi, F., & Clerici, M.
- Affiliations
- University of Milano-Bicocca (IT)
- University of British Columbia (CA)
- Psychiatric Department, Azienda Socio Sanitaria Territoriale Monza, Monza, Italy
- Corresponding author
- di Giacomo, Ester
- Venue
- JAMA Pediatrics
- Publisher
- American Medical Association (AMA)
- Published
- 2018-12-01
- Volume
- 172
- Issue
- 12
- Pages
- 1145
- ISSN
- 1072-4710 (ISSN-L)
- 2168-6203
- PMC
- PMC6583682
- OpenAlex
- W2897499017
- Cited by
- 253
- References
- 57
- Citations by year
- 2026: 37 · 2025: 39 · 2024: 44 · 2023: 29 · 2022: 42 · 2021: 26 · 2020: 22 · 2019: 13 · 2018: 1
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Pediatrics and Adolescent Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Gender Studies › Gender, Sexuality, and Education
- Keywords
- suicide attempts, sexual minority adolescents, suicide risk, sexual orientation, homosexuality, bisexuality, transgender youth, heterosexual comparison, adolescent mental health, sexual minority health disparities, gender identity, sexual minority stigma
- MeSH terms
- Sexual and Gender Minorities, Adolescent, Child, Female, Humans, Male, Risk Factors, Suicide, Attempted, Prevalence, Young Adult
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