Efficacy and Safety of Basimglurant as Adjunctive Therapy for Major Depression: A Randomized Clinical Trial

Quiroz, Jorge A., Tamburri, Paul, Deptula, Dennis, Banken, Ludger, Beyer, Ulrich, Rabbia, Michael, Parkar, Nikhat, Fontoura, Paulo, Santarelli, Luca·2016·JAMA Psychiatry
DOI 10.1001/jamapsychiatry.2016.0838

Cited by (141)

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  4. Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator
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  5. Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5
    Andrew S. Felts, Alice L. Rodriguez, Ryan D. Morrison, Anna Louise Blobaum, Frank W. Byers, John Scott Daniels, Colleen Marie Niswender, Peter Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte · 2018 · Bioorganic & Medicinal Chemistry Letters
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  8. Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
    Elizabeth S. Childress, Rory A. Capstick, Katherine E. Crocker, Miranda L. Ledyard, Aaron M. Bender, Mallory A. Maurer, Natasha B. Billard, Hyekyung P. Cho, Alice L. Rodriguez, Colleen Marie Niswender et al. · 2024 · ACS Medicinal Chemistry Letters
  9. Development and kilogram-scale synthesis of mGlu5 negative allosteric modulator VU0424238 (auglurant)
    Thomas K. David, Nayak K. Prashanth, M. Rajendraswami, Devendrareddy Pallalu, Arlindo L. Castelhano, Michael J. Kates, Anna Louise Blobaum, Carrie K. Jones, Kyle A. Emmitte, Peter Jeffrey Conn et al. · 2017 · Tetrahedron Letters
  10. Addressing the unmet needs of current antidepressants: does neuroscience help or hinder clinical psychopharmacology research?
    Joseph F. Goldberg, Augustus John Rush · 2017 · Expert Opinion on Pharmacotherapy
  11. Aβ oligomers induce sex-selective differences in mGluR5 pharmacology and pathophysiological signaling in Alzheimer mice
    Khaled S. Abd‐Elrahman, Awatif B. Albaker, Jéssica M. de Souza, Fabiola Mara Ribeiro, Michael G. Schlossmacher, Mario Tiberi, Alison Hamilton, Stephen S. G. Ferguson · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  12. Metabotropic glutamate receptor 5 in depression: Mechanisms and therapeutic potential
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  13. Role of mGlu receptors in psychiatric disorders – Recent advances
    Andrzej Pilc, Shigeyuki Chaki · 2023 · Pharmacology Biochemistry and Behavior
  14. Drugs to Tune Up Glutamatergic Systems: Modulators of Glutamate Metabotropic Receptors
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  15. mGlu Receptor Modulation in Murine Models of Stress and Affective Disorders
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  16. Amygdala-hippocampus circuit regulates stress coping via mGluR5-dependent BDNF signaling
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  17. Discovery of 7-(Pyridin-3-yl)thieno[3,2- b ]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
    Scott H. Henderson, Anna E. Ringuette, David L. Whomble, Rory A. Capstick, Alexa E. Richardson, Mallory A. Maurer, Natasha B. Billard, Xia Lei, Joshua C. Wilkinson, Sri H. Kethanapalli et al. · 2026 · ACS Chemical Neuroscience
  18. New Antidepressant Development in the Treatment of Depression
    Alessandro Spiti, Daniela Caldirola, Giampaolo Perna · 2026 · Advances in experimental medicine and biology
  19. Metabotropic Glutamate Receptors in Anxiety Disorder
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  20. Novel Antidepressant Approaches for Refractory Depression
    Danielle Postorivo, Susannah J. Tye · 2021 · Current Treatment Options in Psychiatry
  21. The Evolving Role of Animal Models in the Discovery and Development of Novel Treatments for Psychiatric Disorders
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  22. An Introduction to the CNS Section of Volume 7: Recent Approvals and Advances in CNS Drug Discovery
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  23. Glutamate Modulators in Major Depressive Disorder
    Timothy M. Cooper, Dan Vlad Iosifescu · 2019 · Elsevier eBooks
  24. A Eulogy fo Justice Peter S. Popovich
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  25. mGluR5 Modulation as a Treatment for Parkinson’s Disease
    Kyle Farmer · 2018 · Carleton University's Institutional Repository (MacOdrum Library, Carleton University)
  26. Anti-Depression a Systematic Review of Analytical methods in Pharmaceuticals
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  27. The complex phenotype and function of spinal cord microglia during ALS progression and the impact of metabotropic glutamate receptor type 5 down-regulation in SOD1G93A mice
    Matilde Balbi, Carola Torazza, Tiziana Altosole, Silvia Ravera, Emanuele Farinini, Sara Tessitore, Francesca Bacchetti, Francesca Rosso, Ilaria Musante, Silvana Alfei et al. · 2025 · Neurobiology of Disease
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  30. Influence de la concentration du glutamate sur la liaison du 18F-FPEB au récepteur métabotropique du glutamate de sous-type 5 : une étude translationnelle
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  31. Computational investigation for exploring botanical ingredients as potential negative allosteric modulators targeting metabotropic glutamate receptor 5
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  32. Biodistribution, Radiation Dosimetry, and Kinetic Modeling of [18F]FPEB PET Imaging of mGluR5 in Healthy Asian Subjects
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  33. BindingDB Entry 50000874: Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5.
    BindingDB · 2020 · UC San Diego
  34. BindingDB Entry 50048986: Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu
    BindingDB · 2019 · UC San Diego
  35. BindingDB Entry 50022732: Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5.
    BindingDB · 2026 · UC San Diego
  36. BindingDB Entry 50006808: Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5.
    BindingDB · 2021 · UC San Diego
  37. BindingDB Entry 50000654: Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation.
    BindingDB · 2019 · UC San Diego
  38. BindingDB Entry 50002356: Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5.
    BindingDB · 2020 · UC San Diego
  39. BindingDB Entry 50023619: Discovery of Thieno[3,2-b]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5.
    BindingDB · 2026 · UC San Diego
  40. BindingDB Entry 50000125: Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.
    BindingDB · 2019 · UC San Diego
  41. BindingDB Entry 50009566: Evaluation of Amides, Carbamates, Sulfonamides, and Ureas of 4-Prop-2-ynylidenecycloalkylamine as Potent, Selective, and Bioavailable Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5.
    BindingDB · 2021 · UC San Diego