Cited by 402Neurotransmitter Receptor Influence on BehaviorGambling Behavior and TreatmentsNeural and Behavioral Psychology Studies

The DOI matches its Crossref record, with a small difference in title or year; 80 of the 81 references it cites were found in a registry or an index.

Disruption of Reward Processing in Addiction: An Image-Based Meta-analysis of Functional Magnetic Resonance Imaging Studies

Open access

Luijten, Maartje, Schellekens, Arnt F., Kühn, Simone, Machielse, Marise W. J., Sescousse, Guillaume·2017·JAMA Psychiatry

DOI 10.1001/jamapsychiatry.2016.3084

Open this paper in CoChat — free account Open PDF

Abstract

IMPORTANCE: Disrupted reward processing, mainly driven by striatal dysfunction, is a key characteristic of addictive behaviors. However, functional magnetic resonance imaging (fMRI) studies have reported conflicting results, with both hypoactivations and hyperactivations during anticipation and outcome notification of monetary rewards in addiction. OBJECTIVE: To determine the nature and direction of reward-processing disruptions during anticipation and outcome notification of monetary rewards in individuals with addiction using image-based meta-analyses of fMRI studies. DATA SOURCES: Relevant publications were identified searching PubMed (inclusion until March 2015) using the following terms: reward, fMRI, substance use, cocaine, cannabis, opiates, alcohol, nicotine, smokers, gambling, gamblers, gaming, and gamers. Authors of included articles were contacted to obtain statistical fMRI maps. STUDY SELECTION: Inclusion criteria: reward task involving monetary reward anticipation and/or outcome; participants showing addictive behaviors; and healthy control group. Exclusion criteria: participants aged younger than 18 years; recreational substance use or gambling; participants at risk for addictive behaviors; and studies using the same patient data as other included studies. DATA EXTRACTION AND SYNTHESIS: Study procedures were conducted in accordance with the Meta-analysis of Observational Studies in Epidemiology guidelines. Using Seed-based d Mapping software, meta-analyses were performed using random-effect nonparametric statistics with group whole brain T-maps from individual studies as input. Analyses were performed across all addictions and for substance and gambling addictions separately. MAIN OUTCOMES AND MEASURES: Group differences (individuals with addiction vs control individuals) in reward-related brain activation during reward anticipation and outcome using fMRI (planned before data collection). RESULTS: Twenty-five studies were included in the meta-analysis, representing 643 individuals with addictive behaviors and 609 healthy control individuals. During reward anticipation, individuals with substance and gambling addictions showed decreased striatal activation compared with healthy control individuals. During reward outcome, individuals with substance addiction showed increased activation in the ventral striatum, whereas individuals with gambling addiction showed decreased activation in the dorsal striatum compared with healthy control individuals. CONCLUSIONS AND RELEVANCE: Striatal hypoactivation in individuals with addiction during reward anticipation and in individuals with gambling addiction during reward outcome is in line with the reward-deficiency theory of addiction. However, the combination of hypoactivation during reward anticipation and hyperactivation during reward outcome in the striatum of individuals with substance addiction may be explained using learning-deficit theory.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jamapsychiatry.2016.3084

Cites

80 of 80 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010
Whiteford, H. A., Degenhardt, L., Rehm, J., Baxter, A. J., Ferrari, A. J., Erskine, H. E., Charlson, F. J., Norman, R. E., Flaxman, A. D., Johns, N., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61611-6 · Cited by 6,006
The size and burden of mental disorders and other disorders of the brain in Europe 2010
Wittchen, H. U., Jacobi, F., Rehm, J., Gustavsson, A., Svensson, M., Jönsson, B., Olesen, J., Allgulander, C., Alonso, J., Faravelli, C., et al. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.07.018 · Cited by 3,754
Neurogenetic Adaptive Mechanisms in Alcoholism
Cloninger, C. R. (1987) · Science · doi:10.1126/science.2882604 · Cited by 2,203
The incentive sensitization theory of addiction: some current issues
Robinson, T. E., & Berridge, K. C. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0093 · Cited by 1,717
The Tobacco Atlas
Mackay, J. M., & Eriksen, M. P. (2002) · Medical Entomology and Zoology · Cited by 1,322
The Reward Deficiency Syndrome: A Biogenetic Model for the Diagnosis and Treatment of Impulsive, Addictive and Compulsive Behaviors
Blum, K., Braverman, E. R., Holder, J. M., Lubar, J. F., Monastra, V. J., Miller, D., Lubar, J. O., Chen, T. J. H., & Comings, D. E. (2000) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2000.10736099 · Cited by 998
Plasticity of reward neurocircuitry and the ‘dark side’ of drug addiction
Koob, G. F., & Le Moal, M. (2005) · Nature Neuroscience · doi:10.1038/nn1105-1442 · Cited by 963
A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps
Radua, J., Mataix-Cols, D., Phillips, M. L., El-Hage, W., Kronhaus, D. M., Cardoner, N., & Surguladze, S. (2012) · European Psychiatry · doi:10.1016/j.eurpsy.2011.04.001 · Cited by 765
Meta-analysis of Functional Magnetic Resonance Imaging Studies of Inhibition and Attention in Attention-deficit/Hyperactivity Disorder: Exploring Task-Specific, Stimulant Medication, and Age Effects
Hart, H., Radua, J., Nakao, T., Mataix-Cols, D., & Rubia, K. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.277 · Cited by 764

Flagged first, then by citations

Show all 81 references

1 of the 81 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

[11]11. Ann N Y Acad Sci. 2011;1216(1):50-61.
[23]23. Schultz W. Reward signaling by dopamine neurons. Neuroscientist. 2001;7(4):293-302.
[32]32. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA. 2000;283(15):2008-2012.

Sorted by citations

Items 301–400 of 402

Exploratory study of associations between monetary reward anticipation brain responses and mu-opioid signalling in alcohol dependence, gambling disorder and healthy controls
Turton, S., Paterson, L. M., Myers, J. F., Mick, I., Lan, C., McGonigle, J., Bowden‐Jones, H., Clark, L., Nutt, D., & Lingford-Hughes, A. R. (2024) · Neuroimage Reports · doi:10.1016/j.ynirp.2024.100211 · Cited by 2
Neural and Behavioral Correlates of Binge Eating in 9- to 10-Year-Old Children
Smith, K. E., Hsu, E., Mason, T. B., & LUO, S. H. (2024) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2024.07.925 · Cited by 4
Reward processing in young people with self-harm behaviour
Yavuz, E., Rodrigues, R., Pascual-Sánchez, A., Lingford-Hughes, A. R., & Simplicio, M. C. D. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.09.038 · Cited by 2
Parent Training for Childhood Conduct Problems
Samimy, S., Schettini, E., Fernhoff, K., Webster-Stratton, C. H., & Beauchaine, T. P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818697-8.00047-9 · Cited by 2
Social closeness and reward sensitivity enhance corticostriatal function during experiences of shared rewards
Smith, D. V., Zaff, O., Wyngaarden, J. Β., Dennison, J. B., Sazhin, D., Chein, J. M., McCloskey, M., Alloy, L. B., Jarcho, J. M., & Fareri, D. S. (2026) · Biological Psychology · doi:10.1016/j.biopsycho.2026.109209 · Cited by 3
Substance Use Disorders: Cognitive Sequelae, Behavioral Manifestations, Neuroimaging Correlates, and Novel Interventions
Mahoney, J. J., Bryant, K. R., & Haut, M. W. (2019) · Springer eBooks · doi:10.1007/978-3-030-14895-9_32 · Cited by 2
Neuroimaging tests for clinical psychiatry: Are we there yet?
Leyton, M., & Kennedy, S. H. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.170109 · Cited by 2
The angiotensin antagonist Losartan modulates social reward motivation and punishment sensitivity via modulating midbrain-striato-frontal circuitsPreprint
Zhou, X., Xu, T., Zeng, Y., Zhang, R., Qi, Z., Zhao, W., Kendrick, K. M., & Becker, B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.19.452920 · Cited by 2
Brain Imaging and Substance Use Disorders: Focus on White Matter Microstructural Integrity
Rossetti, M. G., Crisanti, C., Brambilla, P., & Lorenzetti, V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00117-1 · Cited by 2
Neuroimaging the effects of smartphone (over-)use on brain function and structure – a review on the current state of MRI-based findings and roadmap for future researchPreprint
Becker, B., & Montag, C. (2022) · doi:10.31234/osf.io/gh37e · Cited by 2
A generalizable computational mechanism underlying the interaction between momentary craving and decision-makingPreprint
Kulkarni, K. R., Berner, L. A., Rhoads, S. A., Fiore, V. G., Schiller, D., & Gu, X. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.24.538109 · Cited by 2
Negative symptoms in alcohol use disorder: A pilot study applying the two-factor model of negative symptoms to patients with alcohol use disorder
Buschner, M., Dürsteler, K. M., Fischli, G., Hess, J., Kirschner, M., Kaiser, S., & Herdener, M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.957924 · Cited by 1
Impulsivity, Decision-Making, and Reward System as Key Factors in Addiction
Grassi, G., Cecchelli, C., & Vignozzi, L. (2022) · Springer eBooks · doi:10.1007/978-3-030-92392-1_31 · Cited by 1
Abnormal developmental of hippocampal subfields and amygdalar subnuclei volumes in young adults with heavy cannabis use: A three-year longitudinal study
Zhang, X., Chen, Z., Becker, B., Shan, T., Chen, T., & Gong, Q. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111156 · Cited by 1
Substance use disorder severity is associated with sensitivity to effort-related decision-making constraints
Acuff, S. F., Kane, L. F., Stewart, Z., Riddle, J., & Daughters, S. B. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06732-4 · Cited by 1
The Neural Substrates of Individual Differences in Reward Sensitivity in Mental Health
Zald, D. H., & Dennis, N. J. (2025) · Springer eBooks · doi:10.1007/978-3-031-77967-1_6 · Cited by 1
A single-center case-control study of the association between dorsal striatal damage and nicotine addiction
Jing, C., An, X., & Fang, J. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1553200 · Cited by 1
Dual-system perspectives: A meta-analytic comparison of striatal and prefrontal cortex activation patterns in substance addiction versus behavioral addiction
He, Q., Zhaolan, L. I., & Yang, H. (2025) · Acta Psychologica Sinica · doi:10.3724/sp.j.1041.2025.1333 · Cited by 1
Parental substance use history density and its influence on reward anticipation brain activation in late childhood and early adolescence
Navarro, G. Y., Stinson, E. A., Sullivan, R. M., & Lisdahl, K. M. (2025) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2025.101572 · Cited by 2
A narrative review of stress, food choices, and eating behavior: Integrating psychoneuroendocrinology and economic decision-making
Shields, G. S., & Malone, T. (2025) · Journal of Behavioral and Experimental Economics · doi:10.1016/j.socec.2025.102438 · Cited by 17
Neural alterations in substance use disorders: A meta-analysis using activation network mapping across and within task domains
Roberge, M., Dugre, J. R., Boisvert, M., & Potvin, S. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106437 · Cited by 2
Beyond the Feature Level: A Cluster Analysis of Feature-Level Social Media Behaviour Patterns, Maladaptive Use, and Psychological Well-Being
Sramek, Z., Lokuge, S., Sternat, T., Katzman, M. A., & Yatani, K. (2025) · Proceedings of the ACM on Interactive Mobile Wearable and Ubiquitous Technologies · doi:10.1145/3770713 · Cited by 2
Complex wavelet-based Transformer for neurodevelopmental disorder diagnosis via direct modeling of real and imaginary components
Jeong, A.-Y., Heo, D.-W., & Suk, H. (2025) · Medical Image Analysis · doi:10.1016/j.media.2025.103914 · Cited by 1
Task-related differences in network connectivity and dynamics in people with severe opioid use disorder compared with healthy controls
Kurtin, D. L., Herlinger, K., Hayes, A., Hand, L. J., Fonville, L., Hill, R. G., Nutt, D. J., Lingford-Hughes, A. R., & Paterson, L. M. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03845-6 · Cited by 1
The association between cannabis use and brain reward anticipation: a 12-month longitudinal study of adults and adolescents who use cannabis and age-matched controls
Skumlien, M., Wang, S., Freeman, T. P., Eddison, M., Petrilli, K., Wall, M. B., Mokrysz, C., Curran, H. V., & Lawn, W. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02377-3 · Cited by 1
Behavioural and electrophysiological (event-related potential) determinants of decision-making in individuals with a smoking habit
Dampuré, J., Agudelo-Orjuela, P., van der Meij, M., Barber, H. A., & Belin, D. (2026) · Frontiers in Psychology · doi:10.3389/fpsyg.2026.1743972 · Cited by 1
An opioid-withholding human laboratory paradigm during opioid agonist treatment for opioid use disorder and chronic pain: Phase- and dose-dependent effects of cannabidiol
Costa, G. P. A., Sofuoglu, M., Compton, P. A., Ranganathan, M., Pittman, B. P., & Aquino, J. P. D. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02443-w · Cited by 1
Brain reward function in young people with cannabis use disorder: A functional magnetic resonance imaging study
Skumlien, M., Greenwood, L., Arun, A. H., Goodwin, I., Paloubis, A., Rana, T. T., Quinones‐Valera, M., McTavish, E., Abbott, G., Dunsford, S., et al. (2026) · Addiction · doi:10.1111/add.70492 · Cited by 1
Targeting cortico-striatal-amygdalar networks via theta-band frontoparietal synchronization in opioid use disorder: a randomized tACS-fMRI Trial
Soleimani, G., Kuplicki, R., Paulus, M. P., & Ekhtiari, H. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03694-1 · Cited by 3
Are There Differences in Disruptions of Reward Processing Between Substance Use Disorder and Gambling Disorder?—Reply
Schellekens, A., Luijten, M., & Sescousse, G. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.1054 · Cited by 1
Self-citation
Dysfonctionnements du système de récompense et biais cognitifs chez les joueurs pathologiques
Dreher, J. (2021) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/j.banm.2021.05.010 · Cited by 3
The susceptibility of compulsive traits and neural substrates of the prefrontal and anti-reward systems implicated in drug addiction
Yan, W.-S., Liu, S.-J., Zhang, R., & Peng, X. U. (2021) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2021.01345 · Cited by 1
Developmental aspects (including cyberbullying)
Mestre‐Bach, G., Fernández‐Aranda, F., Jiménez‐Múrcia, S., & Potenza, M. N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822201-0.00007-1 · Cited by 1
Immersion in Substance-Related and Behavioural Addictions: Neural Systems and Neurochemical Substrates
Arshad, F., & Clark, L. (2022) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-021-00242-9 · Cited by 2
Structural and Functional Imaging of Alcohol’s Effects on the Brain
Gowin, J. L., Kirk‐Provencher, K. T., Karoly, H. C., & Schacht, J. P. (2023) · Springer eBooks · doi:10.1007/978-3-031-32483-3_26 · Cited by 3
Die IMAGEN-Kohorte: Perspektiven und Probleme longitudinaler Forschung
Heinz, A., Mascarell-Maricic, L., Liu, S., Walter, H., Schumann, G., & Beck, A. (2020) · Der Nervenarzt · doi:10.1007/s00115-020-01034-4 · Cited by 1
Interventions to digital addiction: An umbrella review of meta-analyses (Preprint)Preprint
Lu, P., Qiu, J., Huang, S., Wang, X., Zhu, S., Zeng, F., & Yuan, Y. (2024) · doi:10.2196/preprints.59656 · Cited by 1
Advancing image-based meta-analysis for fMRI: A framework for leveraging NeuroVault dataPreprint
Peraza, J. A., Kent, J. D., Blair, R. W., Poline, J., Nichols, T. E., de la Vega, A. I., & Laird, A. R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.06.641922 · Cited by 1
Functional Magnetic Resonance Imaging Studies of Obsessive-Compulsive and Related Disorders
Han, J., & Kwon, J. S. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108164313.010
WITHDRAWN: Relationship between functional connectivity between the ventral striatum and right ventrolateral prefrontal cortex and individual differences in goal-engagement dimensions of impulsive sensation seeking
Chase, H. W., Graur, S., Fournier, J. C. J., Bertocci, M. A., Greenberg, T., Aslam, H. A., Stiffler, R. S., Lockovich, J., Bebko, G. M., Iyengar, S., et al. (2018) · Cortex · doi:10.1016/j.cortex.2018.11.011
Responsivity of the brain reward network to the taste of beer in light, at-risk, and dependent alcohol users
Groefsema, M. M., Engels, R. C. M. E., Voon, V., Schellekens, A., Luijten, M., & Sescousse, G. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.11.710
Self-citation
Discounting Behavior in Problem GamblingPreprint
Ring, P., Probst, C., Neyse, L., Wolff, S., Kaernbach, C., van Eimeren, T., & Schmidt, U. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3577426
P.009 MDK gene expression is correlated with human brain activity during acceptance of monetary rewards
Komorowski, A., Singh, A., Vidal, R. O., Murgaš, M., Pena‐Centeno, T., Gryglewski, G., Kasper, S. F., Wiltfang, J., Lanzenberger, R. R., & Goya‐Maldonado, R. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.09.015
Inhibitory control, attentional bias and craving, and their underlying neural substrates, in the maintenance of alcohol consumption
McNeill, A. M. (2020)
Left Hippocampus to Anterior Cingulate Cortex Connectivity Correlates with Worse Recent Verbal Memory in Pornography Addicted JuvenilesPreprint
Prawiroharjo, P., Edison, R. E., Ellydar, H., Pratama, P., Suaidy, S. E. I., Amani, N. Z., Carissima, D., & Hatta, G. F. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.23.424123
Neurocognition in stimulant addiction: reply to Robbins (2021)
Becker, B. (2021) · Psychoradiology · doi:10.1093/psyrad/kkab010
Faculty Opinions recommendation of Neuroimaging impaired response inhibition and salience attribution in human drug addiction: A systematic review.
Hayden, B. Y. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733400071.793565472
Gambling Disorder as an Addiction
Macdonald-Gagnon, G., & Potenza, M. N. (2022) · Springer eBooks · doi:10.1007/978-3-030-67928-6_157-1
Etiopatogenia de las drogodependencias: una síntesis explicativa desde una perspectiva epigenética
Cassiani-Miranda, C. A., Palomino, A. B., Arismendy-López, Y. A., & la hoz, N. M. S. D. (2022) · Medicina UPB · doi:10.18566/medupb.v41n2.a06
Subjective assessments of research domain criteria constructs in addiction and compulsive disorders: a scoping review protocol
Ribeiro, A. P., Piquet‐Pessôa, M., Félix-da-Silva, C., Muhlbauer, J. E., Andrade, J. B. D. S., & Fontenelle, L. F. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-059232
Gambling Disorder as an Addiction
Macdonald-Gagnon, G., & Potenza, M. N. (2022) · Springer eBooks · doi:10.1007/978-3-030-92392-1_157
Disentangling Brain Network Connectivity During Monetary and Drug-Related Reward Processing in Stimulant Use Disorder
Beck, A. (2023) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2023.03.006
A taxonomy of reward processing and associations with problematic alcohol use in young, hazardous drinkersPreprint
Simeonov, L., Valton, V., Hindocha, C., Raja, A., Cagatayli, S., Bono, D., Klein, N., Freeman, T. P., Roiser, J. P., Curran, V., et al. (2023) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/vpbf5
A novel technique for delineating the effect of variation in the learning rate on the neural correlates of reward prediction errors in model-based fMRI
Chase, H. W. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1211528 · Cited by 1
Interventions to digital addiction: An umbrella review of meta-analyses (Preprint)Preprint
Lu, P., Qiu, J., Huang, S., Wang, X., Zhu, S., Zeng, F., & Yuan, Y. (2024) · doi:10.2196/preprints.59437
Reduced brain connectivity underlying value-based choices and outcomes in stimulant use disorder
Nestor, L. J., Lim, T. V., Robbins, T. W., & Ersche, K. D. (2024) · NeuroImage Clinical · doi:10.1016/j.nicl.2024.103676
Neurobiologie
Walter, M., & Schmidt, A. (2024) · Elsevier eBooks · doi:10.1016/b978-3-437-21074-7.00003-4
Sports Gambling Experiences and Behaviors at a U.S. Public UniversityPreprint
Mortenson, L. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5147879
Potential therapeutic effects of psychedelics in small doses: Is there a role for microdosing in psychiatry?
Totomanova, I., Haijen, E. C. H. M., Hurks, P. P. M., Ramaekers, J. G., & Kuypers, K. P. C. (2025) · International review of neurobiology · doi:10.1016/bs.irn.2025.03.002
Shared and Distinct Patterns of Neural Dysfunction in Reward and Loss Processing Across Major Depressive Disorder and Addiction: A Neuroimaging Meta-Analytic ReviewPreprint
Yang, X., Huang, Y., Liu, W., Wu, T., Liu, Z., Gao, S., Zheng, Q., Meng, S., Zheng, J.-W., Lu, L., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5225732
Associations Between Taq1A/C957T Polymorphic Variants and Autonomic Responsivity in a Slot Machine Task: Influence of Real-Life Gambling Exposure and Sex
Hultman, C., Rehn, M., Sescousse, G., Nilsson, K. W., Vadlin, S., & Åslund, C. (2025) · Journal of Gambling Studies · doi:10.1007/s10899-025-10398-8
Self-citation
Altered reward feedback processing in methadone maintenance treatment patients: An ERP study using the monetary incentive delay task
Ni, H., Zhang, S., Cai, H., Zhan, G., Lyu, Z., Song, L., Huang, T., Cao, Z., & Chen, J. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111440
White matter microstructure predicts effort and reward sensitivity
Trinh, N., Dricot, L., Vassiliadis, P., Dessain, Q., Duqué, J., Ward, T. E., & Derosière, G. (2026) · NeuroImage · doi:10.1016/j.neuroimage.2026.121732
Similarities and Differences in Neuroimaging
Lin, X., Sun, Y., Zhao, H., Yong Fan, A., Zhang, Z., Meng, S., & Shi, J. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-981-95-2411-2_4
Definition of Substance and Non-substance Addiction
Zou, Z., Wang, X., Wang, H., Wang, X., Ding, J., Uquillas, F. D., & Chen, H. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-981-95-2411-2_1
Cortical morphological alterations in methamphetamine-induced psychosis: a surface-based morphometry study
Shen, D., Luo, D., Lai, M., Tao, H., Xu, J., & Li, J. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07603-8
Additional file 1 of Genetics and prescription opioid use (GaPO): study design for consenting a cohort from an existing biobank to identify clinical and genetic factors influencing prescription opioid use and abuse
Troiani, V., Crist, R. C., Doyle, G. A., Ferraro, T. N., Beiler, D. L., Ranck, S., McBryan, K., Jarvis, M. A. E., Barbour, J. S., Han, J. J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16879994
Additional file 1 of Transdiagnostic considerations of the relationship between reward sensitivity and psychopathological symptoms - a cross-lagged panel analysis
Potsch, L., & Rief, W. (2023) · Figshare · doi:10.6084/m9.figshare.24089329
Association of Neural Responses to Drug Cues With Subsequent Relapse to Stimulant UsePreprint
Knutson, B. D., & MacNiven, K. H. (2020) · OSF Preprints (OSF Preprints)
Positive face BOLD response and task-dependent ventral striatal functional connectivity during Go/No-go task among abstinent cannabis-using adolescents and young adults
Sullivan, R. M., Wallace, A. L., Tomas, C. W., Wirtz, H. G., Larson, C. L., & Lisdahl, K. M. (2026) · Frontiers in Adolescent Medicine · doi:10.3389/fradm.2026.1737529
The highs and lows: Cannabis use and positive valence bipolar mood and emotion processes in emerging adults
Rosa, L., Young, G. R., Ibonie, S. G., LeMoult, J., Mauss, I. B., Alloy, L. B., Borelli, J. L., Holley, S. R., Jopling, E. N., Moriarity, D. P., et al. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121640
Altered Resting-State Functional Connectivity in Internet Gaming Disorder: Convergent Evidence and Independent Validation
Tian, J., Zhang, H., Wang, X., Zhang, H., Ma, L., Mei, B., Zhang, M., Lang, Y., Wei, Y., Han, S., et al. (2026) · Addictive Behaviors Reports · doi:10.1016/j.abrep.2026.100703
Neural imbalance between feedback sensitivity and motor inhibition in compulsivity and negative urgency
Dieterich, R., Overmeyer, R., Dück, K., Wuellhorst, V., & Endraß, T. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-04098-z
Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism
Sambuco, N., Lupo, A., Hawkins, P. C. T., Selvaggi, P., Antonucci, L. A., Bertolino, A., Blasi, G., Palo, P. D., Grassi, L., Grasso, D., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-77317-2
Cortical and Subcortical Signatures of Incentive Salience Attribution in Tobacco Use Disorder
Sambuco, N., Versace, F., & Taylor, B. A. (2026) · Addiction Biology · doi:10.1111/adb.70151
Decisional incentive sensitivity is linked to contingency management outcome and striatal dopamine signaling in individuals with cocaine use disorder: a preliminary study
Vadhan, N. P., Carpenter, K. M., Benedict, E., Myers, C. E., Gluck, M. A., Martinez, D., & Nunes, E. V. (2026) · Addiction and substance abuse · doi:10.46439/addiction.4.011
Sweet-taste liking is associated with preference for less risky and immediate rewards in economic decision-making
Davidovich, A., Shestakova, A. N., Arzumanyan, N., & Panidi, K. (2026) · Frontiers in Psychology · doi:10.3389/fpsyg.2026.1764306
Developmental Trajectories of Gambling and Substance use Throughout Adolescence – A Population-Based Longitudinal Study of Preadolescent Risk Factors and Related Outcomes in Early Adulthood
Carbonneau, R., Vitaro, F., Brendgen, M. R., Boivin, M., Côté, S. M., & Tremblay, R. E. (2026) · Journal of Gambling Studies · doi:10.1007/s10899-026-10512-4
Effects of working memory and reward reactivity on externalizing behaviors in the ABCD study
Schettini, E., Cheavens, J. S., & Saygin, Z. M. (2026) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2026.101743
Reward Processing in Binge Eating and Harmful Drinking: A Systematic Review
Breddy, T. N., Schmidt, K. M., & Bodell, L. P. (2026) · International Journal of Eating Disorders · doi:10.1002/eat.70133
Preadolescent reward processing differentiates irritability trajectories across early adolescence
Quam, A. J., Parker, A. J., Jordan, L. S., Wiggins, J. L., & Dougherty, L. R. (2026) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2026.101093
Disrupted brain functional networks in adolescents and young adults with gaming disorder during social interaction: An fNIRS study
Zipan, W., Huang, C., Shan, H., Wang, Y., Li, S., Guo, L., Lyu, X., Chen, Y., Zeng, Y., Su, H., et al. (2026) · Psychological Medicine · doi:10.1017/s0033291726104176
Learning Mechanisms in Alcohol Use Disorders
Heinz, A., Icoez, S., Treusch, Y., Chiara, G. D., & Halil, M. G. (2026) · Addiction Biology · doi:10.1111/adb.70168
Machine learning model based on spontaneous brain activity and functional connectivity for identifying patients with internet gaming disorder
Yu, M., Xiao, Z., Liu, S., Zhang, D., Cui, N., Lu, X., Lei, W., & Chen, G. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.06.018
Neural correlates of appetitive learning and extinction in individuals with risky gaming use and gaming disorder
Krikova, K., Kampa, M., Klein, S., Stark, R., & Klucken, T. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116341
Co-occurring Psychiatric Disorders
Maruti, S. (2026) · Springer eBooks · doi:10.1007/978-3-032-24174-0_22
Investigating functional connectivity differences during food vs. monetary reward processing across appetitive phenotypes of major depressive disorder
Brassard, S. L., Ahn, H. M., Cerit, H., Hye, T., Durham, E. L., Chang, R. S., Hall, J., Boukezzi, S. C., Goldstein, J. M., Dillon, D. G., et al. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.122235
Reimagining the biopsychosocial model: hierarchical mechanisms from transdiagnostic to precision psychiatry
Leyton, M. (2026) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn-2026-0063
Prefrontal transcranial direct current stimulation in alcohol use disorder: a pilot randomized sham-controlled trial with exploratory effects on reward craving and depressive symptoms
Miuli, A., Chiappini, S., Cavallotto, C., Carlo, F. D., Mosca, A., d’Andrea, G., Battista, D. D., Semeraro, F. M., Marrangone, C., Mancusi, G., et al. (2026) · Addictive Behaviors · doi:10.1016/j.addbeh.2026.108798
Emotional expression differently modulates reward anticipation in gain and loss contexts
Jian, Y., Zhang, Y., & Wei, P. (2026) · Biological Psychology · doi:10.1016/j.biopsycho.2026.109365
Common and disorder-specific aberrant activation during reward and loss processing in major depressive disorder and addiction: a meta-analysis of fMRI studies
Yang, X., Huang, Y., Liu, W., Wu, T., Liu, Z., Gao, S., Zheng, Q., Dou, Z., Zheng, J., Meng, S., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03794-y
Investigating hierarchical control among functional networks disrupted by opioid use disorder using effective connectivity
Austin, B., Kurtin, D. L., Herlinger, K., Hayes, A., Hand, L. J., Fonville, L., Hill, R. G., Nutt, D., Lingford-Hughes, A. R., & Paterson, L. M. (2026) · Imaging Neuroscience · doi:10.1162/imag.a.1373
A systematic review of electrophysiological markers of reward processing in addiction
Staniszewska, A., Gola, M., & Szumska, I. (2026) · Addictive Behaviors · doi:10.1016/j.addbeh.2026.108847
Blunted neurophysiological responses to loss feedback characterize the emotionally vulnerable type of clinical samples with gambling disorder
Zhong, G., Liu, J., Gao, X., Xue, Q., Xue, C., Zhang, X., Bai, Y., Yue, J., Wang, L., Du, J., et al. (2026) · Psychological Medicine · doi:10.1017/s0033291726105534
The adolescent reward system: Longitudinal brain–behavior dynamics and pandemic effects
Kiss, O., Baker, F. C., Harkness, A., Gombert, M., Tapert, S. F., Marshall, A. T., Sowell, E. R., Shao, L. Y., Xu, B., Fan, C. C., et al. (2026) · Development and Psychopathology · doi:10.1017/s095457942610193x
Increases in striatal response to reward anticipation relate to reductions in impulsivity in women with substance use disorders
Lavalley, C. A., Joshi, S., Kuplicki, R., Stewart, J. L., Choquette, E. M., Savitz, J. B., Paulus, M. P., & Aupperle, R. L. (2026) · NeuroImage Clinical · doi:10.1016/j.nicl.2026.104074
Effects of Tai Chi Fan Training on Impulsivity and Inhibitory Control in Patients with Substance Use Disorder: A Randomized Controlled Trial
Wang, X., Ding, B., Lu, M., & Tian, Y. (2026) · Trends in physical education and sport · doi:10.31489/3081-0531/2026-2-3(5)/25-32
Effects of Tai Chi Fan Training on Impulsivity and Inhibitory Control in Patients with Substance Use Disorder: A Randomized Controlled Trial
Wang, X., Ding, B., Lu, M., & Tian, Y. (2026) · Trends in physical education and sport · doi:10.31489/3081-0531/2026-3-5/25-32
Effects of Tai Chi Fan Training on Impulsivity and Inhibitory Control in Patients with Substance Use Disorder: A Randomized Controlled Trial
Wang, X., Ding, B., Lu, M., & Tian, Y. (2026) · Trends in physical education and sport · doi:10.31489/3081-0531/2026-3-5/25-31
Retrieval-aversive conditioning disrupts craving-related circuits to natural gaming videos in internet gaming disorderPreprint
Li, Y., Li, S., Wei, M., Luo, X., He, Y., Li, R., & Dong, G. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7592581

Authors: Luijten, M., Schellekens, A. F., Kühn, S., Machielse, M. W. J., & Sescousse, G.
Affiliations: Radboud University Nijmegen (NL)
Radboud University Medical Center (NL)
University Medical Center Hamburg-Eppendorf (DE)
Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author: Luijten, Maartje
ORCID: Luijten, Maartje
Schellekens, Arnt F.
Kühn, Simone
Sescousse, Guillaume
Venue: JAMA Psychiatry
Publisher: American Medical Association (AMA)
Published: 2017-04-01
Volume: 74
Issue: 4
Pages: 387
ISSN: 2168-622X (ISSN-L)
DOI: 10.1001/jamapsychiatry.2016.3084
OpenAlex: W2584830124
Cited by: 402
References: 81
Citations by year: 2026: 44 · 2025: 37 · 2024: 24 · 2023: 43 · 2022: 47 · 2021: 48 · 2020: 55 · 2019: 49 · 2018: 40 · 2017: 14
FWCI: 5.31
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JAMA Psychiatry (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: reward processing, addiction, striatal dysfunction, reward anticipation, reward outcome, monetary rewards, substance use disorders, gambling addiction, ventral striatum, dorsal striatum, brain activation
MeSH terms: Adult, Brain, Brain Mapping, Female, Gambling, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Motivation, Reference Values, Reward, Software, Substance-Related Disorders, Anticipation, Psychological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Disruption of Reward Processing in Addiction: An Image-Based Meta-analysis of Functional Magnetic Resonance Imaging Studies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks