Targeting Withdrawal Symptoms in Men Addicted to Methamphetamine With Transcranial Magnetic Stimulation: A Randomized Clinical Trial
Open accessAbstract
This randomized clinical trial examines the use of transcranial magnetic stimulation targeting the left dorsal-lateral prefrontal cortex to modulate withdrawal symptoms in men addicted to methamphetamine.
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Two early pilots of mirtazapine (15-60 mg/d for 14 days and 60 mg/d for 10 days) showed significant reductions in standard measures of MA withdrawal symptoms over placebo or sham conditions.
“Two early pilots of mirtazapine (15-60mg/d for 14 days; (41) and 60mg/d for 10 days (38))”
From Clinical management of psychostimulant withdrawal: review of the evidence (2023) · cites this paper as [41]
In a randomized placebo-controlled trial, repetitive transcranial magnetic stimulation (10 Hz, left DLPFC) produced significantly greater reductions in craving compared to sham.
“Significantly greater reductions in withdrawal symptoms, craving, depressive symptoms, anxiety symptoms, and greater”
From Clinical management of psychostimulant withdrawal: review of the evidence (2023) · cites this paper as Liang, Y. et al., 2018
In a randomized placebo-controlled trial, repetitive transcranial magnetic stimulation (10 Hz, left DLPFC) produced significantly greater reductions in anxiety symptoms compared to sham.
“Significantly greater reductions in withdrawal symptoms, craving, depressive symptoms, anxiety symptoms, and greater”
From Clinical management of psychostimulant withdrawal: review of the evidence (2023) · cites this paper as Liang, Y. et al., 2018
In a randomized placebo-controlled trial, repetitive transcranial magnetic stimulation (10 Hz, left DLPFC) produced significantly greater reductions in withdrawal symptoms compared to sham.
“Significantly greater reductions in withdrawal symptoms, craving, depressive symptoms, anxiety symptoms, and greater”
From Clinical management of psychostimulant withdrawal: review of the evidence (2023) · cites this paper as Liang, Y. et al., 2018
In a randomized placebo-controlled trial, repetitive transcranial magnetic stimulation (10 Hz, left DLPFC) produced significantly greater reductions in depressive symptoms compared to sham.
“Significantly greater reductions in withdrawal symptoms, craving, depressive symptoms, anxiety symptoms, and greater”
From Clinical management of psychostimulant withdrawal: review of the evidence (2023) · cites this paper as Liang, Y. et al., 2018
Cited by
Sorted by citations
Neurobiology, Clinical Presentation, and Treatment of Methamphetamine Use Disorder: A Review
Paulus, M. P., & Stewart, J. L. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.0246 · Cited by 310 · see citing works
Clinical management of psychostimulant withdrawal: review of the evidence
Li, M. J., & Shoptaw, S. J. (2023) · Addiction · doi:10.1111/add.16093 · Cited by 39 · see citing works
- Authors
- Liang, Y., Wang, L., & Yuan, T.-F.
- Affiliations
- Nanjing University (CN)
- Nanjing Normal University (CN)
- Corresponding author
- Yuan, Ti-Fei
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2018-11-01
- Volume
- 75
- Issue
- 11
- Pages
- 1199
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC6583874
- OpenAlex
- W2891889239
- Cited by
- 69
- References
- 0
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 6 · 2023: 6 · 2022: 12 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 2
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (71473117)
- Shanghai Rising-Star Program
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- methamphetamine dependence, withdrawal symptoms, transcranial magnetic stimulation, men, addiction treatment, neurostimulation
- MeSH terms
- Adult, Central Nervous System Stimulants, Double-Blind Method, Humans, Male, Methamphetamine, Substance Withdrawal Syndrome, Behavior, Addictive, Treatment Outcome, Amphetamine-Related Disorders, Transcranial Magnetic Stimulation, Young Adult
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