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Resistance management strategies in malaria vector mosquito control. A large-scale field trial in southern Mexico
Abstract
ATP-binding cassette (ABC) transporters are members of a protein superfamily which can be responsible for efflux of drugs from cells of target organisms. In this way, the transporters may provide a mechanism of protection against cytotoxic drugs. In laboratory-generated mutants of fungi, overproduction of ABC transporters can cause multi-drug resistance to azoles and other non-related toxicants. The impact of this mechanism of resistance in field populations with decreased sensitivity to azoles remains to be established. Inhibitors of ABC transporter activity may synergize activity of azoles to populations of both sensitive and azole-resistant pathogens. The natural function of ABC transporters in plant pathogenic fungi may relate to transport of plant-defence compounds or fungal pathogenicity factors. Therefore, inhibitors of ABC transporter activity may act as disease control agents with an indirect mode of action. ©1997 SCI
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“Even an intelligent insecticide resistance management strategy using rotations, mosaics, or mixtures may not prevent resistance development (Hemingway et al. 1997; Penilla et al. 2006).”
From Global Status of DDT and Its Alternatives for Use in Vector Control to Prevent Disease (2009) · cites this paper as Hemingway et al. 1997
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Metadata
- Authors
- Hemingway, J., Penilla, R. P., Rodriguez, A. D., James, B. M., Edge, W., Rogers, H., & Rodriguez, M. H.
- Venue
- Pesticide Science
- Published
- 1997
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- CoChat. (2026). Citation check: Resistance management strategies in malaria vector mosquito control. A large-scale field trial in southern Mexico. https://app.cochat.ai/papers/10.1002/(sici)1096-9063(199711)51:3
- The paper
- Hemingway, J., Penilla, R. P., Rodriguez, A. D., James, B. M., Edge, W., Rogers, H., & Rodriguez, M. H. (1997). Resistance management strategies in malaria vector mosquito control. A large-scale field trial in southern Mexico. Pesticide Science. https://doi.org/10.1002/(sici)1096-9063(199711)51%3A3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
