Loss of one but not twomdm2 null alleles alters the tumour spectrum inp53 null mice
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p53-null mice heterozygous for Mdm2 or overexpressing Mdm2 from a transgene have an altered tumor spectrum compared to that of mice lacking p53 alone.
“p53-null mice heterozygous for Mdm2 or overexpressing Mdm2 from a transgene have an altered tumor spectrum compared to that of mice lacking p53 alone (22, 32).”
From Mdm2 Promotes Genetic Instability and Transformation Independent of p53 (2008) · cites this paper as [32]
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- Authors
- McDonnell, T. J., Montes de Oca Luna, R., Cho, S., Amelse, L. L., Chavez-Reyes, A., & Lozano, G.
- Venue
- The Journal of Pathology
- Published
- 1999
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