Expression pattern of twoFrizzled-related genes,Frzb-1 andSfrp-1, during mouse embryogenesis suggests a role for modulating action ofWnt family members
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A number of secreted proteins that bind to Wnts and prevent their interaction with either Fz or LRP5/6 to antagonize Wnt signaling have been identified, including Dickkopf (Dkk) proteins, Wnt-inhibitor protein (WIF), soluble Frizzled-related proteins (SFRP), Cerebrus, Frzb and Wise.
“In the extra-cellular matrix, a number of secreted proteins that bind to Wnts and prevent their interaction with either Fz or LRP5/6 to antagonize Wnt signaling have been identified. These include Dickkopf (Dkk) proteins,16 Wnt-inhibitor protein (WIF),17 soluble Frizzled-related proteins (SFRP),18 Cerebrus,19 Frzb20 and the context dependent Wnt inhibitor Wise.21”
From Wnt signal transduction pathways (2008) · cites this paper as [18]
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- Authors
- Hoang, B. H., Thomas, J. T., Abdul-Karim, F. W., Correia, K. M., Conlon, R. A., Luyten, F. P., & Ballock, R. T.
- Venue
- Developmental Dynamics
- Published
- 1998
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