The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Axinellins A and B: New Proline-Containing Antiproliferative Cyclopeptides from the Vanuatu SpongeAxinella carteri
Abstract
Two new bioactive cyclopeptides, named axinellins A (1) and B (2) have been isolated from the marine sponge Axinella carteri. Their structure elucidation was based on two-dimensional (2D) NMR (500 MHz) as well as HRFABMS and ESMS/MS data. All amino acid residues derived from axinellins A and B were found to possess L configuration at Cα by HPLC analysis of their FDAA derivatives (Marfey's method). The amino acid sequence of 1 and 2 was established on the basis of tandem mass spectrometry data (ESMS/MS) and on 1H-1H through-space connectivities observed in NOESY and ROESY spectra. Axinellins A (1) and B (2) exhibited moderate in vitro antitumor activity against human broncopulmonary non-small-cell-lung-carcinoma lines (NSCLC-N6) with IC50 values of 3.0 and 7.3 μg/ml, respectively.
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Kobayashi, J., Tsuda, M., Nakamura, T., Mikami, Y., & Shigemori, H. (1993) · Tetrahedron · doi:10.1016/s0040-4020(01)86318-3 · Cited by 74
Cited by
Yu, Y., Li, Y., Wang, X., Nian, H., Wang, L., Li, J., Zhao, Y., Yang, X., Liu, S., & Cao, L. (2017) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.7b00400 · Cited by 66
Anand, M., Alagar, M., Ranjitha, J., & Selvaraj, V. (2019) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2014.05.037 · Cited by 19
Progress in the chemical synthesis of brassinosteroids
Kovganko, N. V., & Ananich, S. K. (2002) · Chemistry of Natural Compounds · doi:10.1023/a:1019679729103 · Cited by 9
Metadata
- Authors
- Randazzo, A., Dal Piaz, F., Orrù, S., Debitus, C., Roussakis, C., Pucci, P., & Gomez-Paloma, L.
- Venue
- European Journal of Organic Chemistry
- Published
- 1998
- References
- 1
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