Characterization of Tertiary Folding of RNA by Circular Dichroism and Urea
Open accessAbstract
CD spectroscopy can be used to monitor RNA tertiary folding transitions that may not be observable by absorbance spectroscopy. With the use of computer‐controlled titrators, data can be acquired rapidly, and accurate thermodynamic properties can be obtained over a wide variety of conditions. Thus, CD spectroscopy provides a useful complement to site‐resolved or chemical modification methods.
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The LNP composition used was the same as the Pfizer-BioNTech vaccine.
“LNPs with the same composition as the Pfizer-BioNTech vaccine23 were used to deliver A30L70- or A/G-tailed mRNA encoding firefly luciferase (Fluc) by intramuscular injection”
From Evaluation of synthetic mRNA with selected UTR sequences and alternative poly(A) tail, in vitro and in vivo (2025) · cites this paper as [23]
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Medjmedj, A., Genon, H., Hezili, D., Loth, A. N., Clemençon, R., Guimpied, C., Mollet, L., Bigot, A., Wien, F., Hamacek, J., et al. (2025) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2025.102648 · Cited by 19 · see citing works
- Authors
- Sosnick, T. R.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Sosnick, Tobin R.
- ORCID
- Sosnick, Tobin R.
- Venue
- Current Protocols in Nucleic Acid Chemistry
- Publisher
- Wiley
- Published
- 2001-04
- Volume
- 4
- Issue
- 1
- Pages
- Unit 11.5-Unit 11.5
- ISSN
- 1934-9270 (ISSN-L)
- 1934-9289
- OpenAlex
- W1524881616
- Cited by
- 30
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 7 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 4 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Protocols in Nucleic Acid Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- RNA tertiary structure, RNA folding, circular dichroism, urea, thermodynamic properties, titration, folding transition
- MeSH terms
- Circular Dichroism, Magnesium, Nucleic Acid Conformation, RNA, Thermodynamics, Urea, Titrimetry
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