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Cited by 63Viral Infections and Immunology ResearchCardiac Fibrosis and RemodelingOcular Diseases and Behçet’s Syndrome

Autoimmune Myocarditis, Valvulitis, and Cardiomyopathy

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Myers, Jennifer M., Fairweather, DeLisa, Huber, Sally A., Cunningham, Madeleine W.·2013·Current Protocols in Immunology
DOI 10.1002/0471142735.im1514s101PMC PMC3672855
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Abstract

Myocarditis and valvulitis are inflammatory diseases affecting myocardium and valve. Myocarditis, a viral‐induced disease of myocardium, may lead to dilated cardiomyopathy and loss of heart function. Valvulitis leads to deformed heart valves and altered blood flow in rheumatic heart disease. Animal models recapitulating these diseases are important in understanding the human condition. Cardiac myosin is a major autoantigen in heart, and antibodies and T cells to cardiac myosin are evident in inflammatory heart diseases. This unit is a practical guide to induction and evaluation of experimental autoimmune myocarditis (EAM) in several mouse strains and the Lewis rat. Purification protocols for cardiac myosin and protocols for induction of EAM by cardiac myosin and its myocarditis‐producing peptides, and coxsackievirus CVB3, are defined. Protocols for assessment of myocarditis and valvulitis in humans and animal models provide methods to define functional autoantibodies targeting cardiac myosin, β‐adrenergic, and muscarinic receptors, and their deposition in tissues. Curr. Protoc. Immunol . 101:15.14.1‐15.14.51. © 2013 by John Wiley & Sons, Inc.

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  • Lewis rats immunized with cardiac myosin develop experimental autoimmune myocarditis with multinucleated giant cells, replicating clinical findings in giant cell myocarditis.

    “The immunized rats developed EAM with multinucleated giant cells, replicating clinical findings in giant cell myocarditis.”

    From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [192]

    Basic Protocol 2 (page not available) states that immunization with cardiac myosin elicits EAM in Lewis rats. The histopathological assessment protocol describes infiltrating mononuclear cells, but our copy does not report multinucleated giant cells in these rats or say that their lesions replicate clinical giant cell myocarditis. (LLM, conf=0.84)

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Authors
Myers, J. M., Fairweather, D., Huber, S. A., & Cunningham, M. W.
Affiliations
  • University of Oklahoma Health Sciences Center (US)
  • Johns Hopkins University (US)
  • University of Vermont (US)
ORCID
Venue
Current Protocols in Immunology
Publisher
Wiley
Published
2013-04
Volume
101
Issue
1
Pages
Unit 15.14.1-51
ISSN
  • 1934-3671 (ISSN-L)
  • 1934-368X
DOI
10.1002/0471142735.im1514s101
PMC
PMC3672855
OpenAlex
W1627734560
Cited by
63
References
137
Citations by year
2026: 3 · 2025: 3 · 2024: 9 · 2023: 8 · 2022: 4 · 2021: 9 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 2
FWCI
2.72
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 14 d)
Locations
  • Current Protocols in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL087033, R56HL056267, R01HL111938, R01HL056267, HL111938, R01HL108371, R37HL035280)
  • National Institute of Allergy and Infectious Diseases (T32AI007633)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
experimental autoimmune myocarditis, valvulitis, dilated cardiomyopathy, autoantibodies, T cells, coxsackievirus B3, animal models, Lewis rats, mouse strains, rheumatic heart disease, autoimmunity
MeSH terms
Animals, Autoantibodies, Autoantigens, Autoimmune Diseases, Coxsackievirus Infections, Disease Models, Animal, Enterovirus, Heart Valves, Humans, Inflammation, Cardiomyopathies, Myocarditis, Receptors, Adrenergic, beta, Receptors, Muscarinic, Autoimmunity, Gene Expression, Cardiac Myosins, Mice, Rats

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