Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up

The DOI matches its Crossref record; its reference list is not available.

The effects of surface chemistry and adsorbed proteins on monocyte/macrophage adhesion to chemically modified polystyrene surfaces

Shen, Mingchao, Horbett, Thomas A.·2001·Journal of Biomedical Materials Research
DOI 10.1002/1097-4636(20011205)57:3
Open this paper in CoChat — free account

Abstract

Room temperature-processed silica sol-gel (xerogel) was investigated as a novel controlled release carrier of vancomycin for the treatment of osteomyelitis. Vancomycin-loaded xerogels were fabricated with varying water/alkoxysilane molar ratios and vancomycin concentrations. The goal of this study was to determine the effect of varying the aforementioned synthesis parameters on the daily in vitro release kinetics of vancomycin from the xerogel disks. A controlled, load-dependent, long-term release of vancomycin was observed for all of the molar ratios that were used in the study (4, 6, and 10). Variations in the water/alkoxysilane molar ratio affected the release process extensively. A cumulative release of about 90% of the original amount of vancomycin was found for molar ratios 6 and 10 by 21 and 14 days, respectively. Only about 30% was released from xerogels with a molar ratio of 4 after 21 days of immersion. A first-order release stage was followed by a steady release stage for xerogels with molar ratios of 6 and 10, whereas zero-order release was observed for xerogels with a molar ratio of 4. The findings of this study indicate that the release kinetics of vancomycin from xerogel can be tailored by varying the xerogel synthesis parameters.

Overview

Integrity signals

Registry

Crossref · 10.1002/1097-4636(20011205)57:3<336::aid-jbm1176>3.0.co;2-e

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

No citation lists for this paper

No citation lists for this paper yet — checked again daily.

Research works printed but not linked: 45

  1. Anderson, 1994, Problems Gen Surg, 11, 147
  2. Horbett, 1993, Cardiovasc Pathol, 2, 137s, 10.1016/1054-8807(93)90054-6 · DOI
  3. Anderson, 1984, Biomaterials, 5, 5, 10.1016/0142-9612(84)90060-7 · DOI · Paper page
  4. Salthouse, 1984, J Biomed Mater Res, 18, 395, 10.1002/jbm.820180407 · DOI · Paper page
  5. Behling, 1986, J Biomed Mater Res, 20, 653, 10.1002/jbm.820200509 · DOI
  6. Ziats, 1988, Biomaterials, 9, 5, 10.1016/0142-9612(88)90063-4 · DOI
  7. Ratner, 1993, J Biomed Mater Res, 27, 837, 10.1002/jbm.820270702 · DOI
  8. Rabinovitch, 1973, Exp Cell Res, 77, 323, 10.1016/0014-4827(73)90584-3 · DOI
  9. Kruskal, 1987, J Cell Biol, 105, 2685, 10.1083/jcb.105.6.2685 · DOI
  10. Friedman, 1987, Immunology, 61, 469
  11. Shaw, 1990, J Cell Biol, 111, 2139, 10.1083/jcb.111.5.2139 · DOI · Paper page
  12. Sporn, 1990, J Immunol, 144, 4434, 10.4049/jimmunol.144.11.4434 · DOI
  13. Thorens, 1987, Cell, 48, 671, 10.1016/0092-8674(87)90245-5 · DOI
  14. Haskill, 1988, J Immunol, 140, 1690, 10.4049/jimmunol.140.5.1690 · DOI
  15. Webb, 1990, Science, 249, 1295, 10.1126/science.1697984 · DOI
  16. Grabbe, 1994, J Invest Dermatol, 103, 504, 10.1111/1523-1747.ep12395649 · DOI
  17. Schmidt, 1982, J Immunol, 128, 673, 10.4049/jimmunol.128.5.2177 · DOI
  18. Montesano, 1985, J Cell Physiol, 122, 424, 10.1002/jcp.1041220313 · DOI
  19. Mattana, 1997, Kidney Int, 52, 1478, 10.1038/ki.1997.478 · DOI
  20. Triglia, 1985, Blood, 65, 921, 10.1182/blood.V65.4.921.921 · DOI
  21. Slack, 1987, Ann NY Acad Sci, 516, 223, 10.1111/j.1749-6632.1987.tb33044.x · DOI
  22. Gordon, 1988, J Cell Sci, 9, 1, 10.1242/jcs.1988.Supplement_9.1 · DOI
  23. Wright, 1988, J Cell Sci, 9, 99, 10.1242/jcs.1988.Supplement_9.5 · DOI
  24. Altieri, 1986, J Clin Invest, 78, 968, 10.1172/JCI112687 · DOI
  25. Tang, 1993, J Exp Med, 178, 2147, 10.1084/jem.178.6.2147 · DOI
  26. Brown, 1989, J Clin Invest, 84, 366, 10.1172/JCI114166 · DOI
  27. Mellman, 1988, J Cell Sci, 9, 45, 10.1242/jcs.1988.Supplement_9.3 · DOI
  28. Altieri, 1988, J Biol Chem, 263, 7007, 10.1016/S0021-9258(18)68596-5 · DOI
  29. Ueda, 1994, Proc Natl Acad Sci USA, 91, 10680, 10.1073/pnas.91.22.10680 · DOI
  30. Davis, 1992, Exp Cell Res, 200, 242, 10.1016/0014-4827(92)90170-D · DOI
  31. Eierman, 1989, J Immunol, 142, 1970, 10.4049/jimmunol.142.6.1970 · DOI
  32. Perez, 1995, J Immunol, 154, 1879, 10.4049/jimmunol.154.4.1879 · DOI
  33. Tobias, 1987, Blood, 69, 1265, 10.1182/blood.V69.4.1265.1265 · DOI
  34. McNally, 1994, Proc Natl Acad Sci USA, 91, 10119, 10.1073/pnas.91.21.10119 · DOI · Paper page
  35. Yun, 1995, J Biomed Mater Res, 29, 257, 10.1002/jbm.820290217 · DOI
  36. DeFife, 1995, J Biomed Mater Res, 29, 431, 10.1002/jbm.820290403 · DOI
  37. Jenney, 2000, J Biomed Mater Res, 49, 435, 10.1002/(SICI)1097-4636(20000315)49:4<435::AID-JBM2>3.0.CO;2-Y · DOI
  38. Jenney, 2000, J Biomed Mater Res, 50, 281, 10.1002/(SICI)1097-4636(20000605)50:3<281::AID-JBM1>3.0.CO;2-5 · DOI
  39. Tang, 1993, J Lab Clin Med, 122, 292
  40. Horbett, 1981, J Biomed Mater Res, 15, 673, 10.1002/jbm.820150506 · DOI
  41. Tsai, 1999, J Biomed Mater Res, 44, 130, 10.1002/(SICI)1097-4636(199902)44:2<130::AID-JBM2>3.0.CO;2-9 · DOI · Paper page
  42. Macrophage interactions with biomaterial surfaces and their effects on endothelial cell activation. Ph.D. dissertation. Seattle: University of Washington; 1998. 247 p.
  43. Altieri, 1991, J Immunol, 147, 1891, 10.4049/jimmunol.147.6.1891 · DOI
  44. Horsburgh, 1987, J Leukoc Biol, 41, 14, 10.1002/jlb.41.1.14 · DOI
  45. Jenney, 1998, J Biomed Mater Res, 41, 171, 10.1002/(SICI)1097-4636(199808)41:2<171::AID-JBM1>3.0.CO;2-F · DOI

Metadata

Authors
Shen, M., & Horbett, T. A.
Venue
Journal of Biomedical Materials Research
Publisher
Wiley
Published
2001
Volume
57
Issue
3
Pages
336-345
ISSN
  • 0021-9304
  • 1097-4636
DOI
10.1002/1097-4636(20011205)57:3
Language
en
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 5356 d)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: The effects of surface chemistry and adsorbed proteins on monocyte/macrophage adhesion to chemically modified polystyrene surfaces. https://app.cochat.ai/papers/10.1002/1097-4636(20011205)57:3
The paper
Shen, M., & Horbett, T. A. (2001). The effects of surface chemistry and adsorbed proteins on monocyte/macrophage adhesion to chemically modified polystyrene surfaces. Journal of Biomedical Materials Research. https://doi.org/10.1002/1097-4636(20011205)57%3A3

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.