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Allergen injection immunotherapy for seasonal allergic rhinitis
Open accessAbstract
BACKGROUND: Allergic rhinitis is the most common of the allergic diseases. Despite improved understanding of the pathophysiology of allergic rhinitis and advances in its pharmacological treatment, its prevalence has increased worldwide. For patients whose symptoms remain uncontrolled despite medical treatment, allergen injection immunotherapy is advised. An allergen-based treatment may reduce symptoms, the need for medication and modify the natural course of this disease. OBJECTIVES: To evaluate the efficacy and safety of subcutaneous specific allergen immunotherapy, compared with placebo, for reducing symptoms and medication requirements in seasonal allergic rhinitis patients. SEARCH STRATEGY: We searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 1 2006), MEDLINE (1950 to 2006), EMBASE (1974 to 2006), Pre-MEDLINE, KOREAMED, INDMED, LILACS, PAKMEDINET, Scisearch, mRCT and the National Research Register. The date of the last search was February 2006. SELECTION CRITERIA: All studies identified by the searches were assessed to identify randomised controlled trials involving participants with symptoms of seasonal allergic rhinitis and proven allergen sensitivity, treated with subcutaneous allergen specific immunotherapy or corresponding placebo. DATA COLLECTION AND ANALYSIS: Two independent authors identified all studies reporting double-blind, placebo controlled randomised trials of specific immunotherapy in patients with seasonal allergic rhinitis due to tree, grass or weed pollens. Two authors independently performed quality assessment of studies. Data from identified studies were abstracted onto a standard extraction sheet and subsequently entered into RevMan 4.2.8. Analysis was performed using the Standardised Mean Difference (SMD) method and a random-effects model; P values < 0.05 were considered statistically significant. The primary outcome measures were symptom scores, medication use, quality of life and adverse events. MAIN RESULTS: We retrieved 1111 publications of which 51 satisfied our inclusion criteria. In total there were 2871 participants (1645 active, 1226 placebo), each receiving on average 18 injections. Duration of immunotherapy varied from three days to three years. Symptom score data from 15 trials were suitable for meta-analysis and showed an overall reduction in the immunotherapy group (SMD -0.73 (95% CI -0.97 to -0.50, P < 0.00001)). Medication score data from 13 trials showed an overall reduction in the immunotherapy group (SMD of -0.57 (95% CI -0.82 to -0.33, p<0.00001)). Clinical interpretation of the effect size is difficult. Adrenaline was given in 0.13% (19 of 14085 injections) of those on active treatment and in 0.01% (1 of 8278 injections) of the placebo group for treatment of adverse events. There were no fatalities. AUTHORS' CONCLUSIONS: This review has shown that specific allergen injection immunotherapy in suitably selected patients with seasonal allergic rhinitis results in a significant reduction in symptom scores and medication use. Injection immunotherapy has a known and relatively low risk of severe adverse events. We found no long-term consequences from adverse events.
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“Total symptom score is the main variable in systematic reviews and meta-analyses, both in SCIT [172] and in SLIT in drops [173] or in tablets [174]; therefore, specific data on NO are not usually published [171].”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [172]
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Citations
Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
Beasley, R. W. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07302-9 · Cited by 3,794
Allergic Rhinitis and Its Impact on Asthma
Bousquet, J., van Cauwenberge, P., & Khaltaev, N. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118891 · Cited by 3,588
Improving the Quality of Reporting of Randomized Controlled Trials: The CONSORT Statement
Begg, C. (1996) · JAMA · doi:10.1001/jama.1996.03540080059030 · Cited by 3,127
Allergen immunotherapy: Therapeutic vaccines for allergic diseases A WHO position paper
Bousquet, J., Lockey, R. F., & Malling, H. ‐. (1998) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(98)70271-4 · Cited by 1,582
Long-Term Clinical Efficacy of Grass-Pollen Immunotherapy
Durham, S. R., Walker, S. M., Varga, E., Jacobson, M. R., O'Brien, F., Noble, W. J., Till, S. J., Hamid, Q. A., & Nouri‐Aria, K. T. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908123410702 · Cited by 1,371
Self-citationMöller, C., Dreborg, S., Ferdousi, H. A., Halken, S., Høst, A., Jacobsen, L., Koivikko, A., Koller, D. Y., Niggemann, B., Norberg, L. A., et al. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.121317 · Cited by 1,065
Research works printed but not linked: 29
- Brewczynski, 1999, Efficacy and safety of immunotherapy with modified grass pollen allergens. Results of a placebo-controlled study, Allergologie, 22, 411
- Hauser, 1995, Inhibitory effect on migration of inflammatory cells into the nasal mucosa by immunotherapy, Allergo Journal, 4, 164
- Berstein, 2001, Double blind placebo controlled (DBPC) study of grapeseed extract in the treatment of seasonal allergic rhinitis (SAR), Journal of Allergy and Clinical Immunology, 107, S311
- Calderon, 2003, Double blind placebo controlled study of specific immunotherapy (SIT) with Alutard SQ grass pollen for seasonal allergic rhinoconjunctivitis, Allergy and Clinical Immunology International, 1, Abstract No. O-
- Crimi, 2001, A randomised double-blind study of specific immunotherapy (SIT) in patients with seasonal allergic-rhinitis: effects on clinical and inflammatory markers, European Respiratory Journal, 18, 482s
- Egger, 1997, The influence of hypo-sensitisation therapy on the sense of smell in subjects with seasonal allergic rhinitis, Allergologie, 20, 525
- Frankland, 1963, Treatment of hay fever by depot injection (shypyrindene) in allergic conditions. Double blind clinical study, Acta Allergologica, 18, 175
- Kerr, 1964, The treatment of hay fever including a controlled trial of the use of alum precipitate pollen adsorbate, Acta Allergologica, 19, 76
- Kuhn, 1985, Hyposensitization in pollen sensitive children: A 3 year prospective study, Allergologie, 8, 103
- Lindsay-Miller, 1971, Pollen Tyrosine in the treatment of hay fever, Clinical Allergy, 1, 351
- Malling, 2000, Allergen specific immunotherapy for asthma, Ugeskr Laeger, 162 (4), 477
- Manger, 1984, Hyposensitization of hay fever patients with Tyrosin-adsorbed grass and rye pollen allergoid. Clinical and immunological parameters during different dosages with TA Tyrosin-Allergoid Gräserpollen, Allergologie, 7, 222
- Mewes, 1999, Short term immune therapy with ALK7 reduces grass-pollen induces rhinoconjunctivitis symptoms and the specific nasal reactivity is more efficient than a symptomatic standard therapy, Allergologie, 22, 581
- Nolte, 1999, Allergen extracts, dosing, efficacy and safety of immunotherapy, International Review of Allergology and Clinical Immunology, 5 (3), 184
- Osterballe, 1982, Immunotherapy in hay fever with timothy major allergens, Allergy, 37, 8
- Pastorello, 1988, A double blind placebo controlled trial of specific immunotherapy with aluminium hydroxide adsorbed allergoid in grass pollen induced rhinitis, Allergy, 43, 48
- Ricca, 1997, Preseasonal specific immunotherapy with modified Phleum pratense allergenic extracts: tolerability and effects, Allergologia et Immunopathologia (Madrid), 25, 167
- Rozniecka, 1995, The characteristics of pollinosis during the pollen season and the influence of specific immunotherapy. Part II: Cytologic changes and chemotactic activity in nasal lavage, Pneumonologia i Alergologia Polska, 63, 144
- Ruiz, 2001, Safety and efficacy of immunotherapy with a standardized depigmented and glutaraldehyde-polyerized extract of phleum pratense pollen, Journal of Allergy and Clinical Immunology, 107, S260
- Sandstrom, 2001, Xolair is effective in the treatment of seasonal birch pollen allergic rhinitis, Annals of Allergy, Asthma and Immunology, 86, 83
- Stuck, 2001, Birch pollen allergoid plus MPL in short-term immunotherapy, Otolaryngology - Head and Neck Surgery, 125, P199
- Sykora, 2004, Efficacy and safety of specific allergen immunotherapy with standardized depod allergen H-AI depot (pollens), Alergie, 6, 170
- Watanabe, 2003, Successful grass pollen immunotherapy inhibits eosinophil accumulation in the nasal mucosa: role of adhesion molecules and apoptosis [Abstract], Allergy and Clinical Immunology International, 15, Abstract No.O-1
- Williams, 2001, A study to determine the efficacy of a nasally administered rye grass peptide, Ptl-0901, in the treatment of severe seasonal hayfever, Journal of Allergy and Clinical Immunology, 107, S256
- Williams, 2002, Effectiveness of preseasonal allergoid immunotherapy in patients with grass pollen allergy [Abstract], Allergy, 57, 51
- Yariktas, 2002, Comparison of Leukotriene Receptor Antagonist and Antihistamine Therapy in Seasonal Allergic Rhinitis, Turkish Archives of Otolaryngology, 40, 252
- Frank, 2001, Effectiveness of a pre-seasonal allergoid immunotherapy in patients with seasonal allergic rhinitis due to grass pollen, Journal of Allergy and Clinical Immunology, 107, S260
- Committee of the Safety of Medicine, 1994, Desensitising vaccines: New advice, Current Problems in Pharmacovigilance, 20, 5
- Durham, 1999, Long-term clinical efficacy of grass-pollen immunotherapy, New England Journal of Medicine, 341(7), 468, 10.1056/NEJM199908123410702 · DOI
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Trivedi, A., & Katelaris, C. H. (2020) · Clinical and Experimental Optometry · doi:10.1111/cxo.13129 · Cited by 7
Immunothérapie allergénique dans le traitement de l’allergie aux pollens
Mailhol, C., & Didier, A. P. (2012) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2012.07.005 · Cited by 7
El‐Qutob, D., Moreno, F., & Subtil‐Rodríguez, A. (2016) · Immunotherapy · doi:10.2217/imt-2015-0017 · Cited by 7
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Ni, W., Wang, L., Zhou, Y., Cao, M.-D., Huang, W., Guo, M., Ji, C., Sun, J., & Wei, J. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6867 · Cited by 7
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Pfaar, O., Mösges, R., Hörmann, K., & Klimek, L. (2009) · HNO · doi:10.1007/s00106-009-1946-8 · Cited by 7
Hauswald, B., Wolf, H., Becker, F., Becker, S., Schnitker, J., & Wüstenberg, E. G. (2013) · PubMed · Cited by 7
Allergen injection immunotherapy for perennial allergic rhinitis
Calderón, M. A., Carr, V. A., Jacobson, M. R., Sheikh, A., & Durham, S. R. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007163 · Cited by 7
Self-citationRetractedGRAZAX®: An Oromucosal Vaccine for Treating Grass Pollen Allergy with Immunotherapy
Lundegaard, A. R., Lund, L., & Larsen, J. N. (2009) · doi:10.1002/9780470688397.ch20 · Cited by 7
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Bona, D. D., Biase, A. D., Paoletti, G., Villani, R., Serviddio, G., Cognet-Sicé, J., Scurati, S., & Canonica, G. W. (2025) · Frontiers in Allergy · doi:10.3389/falgy.2025.1597003 · Cited by 6
He, Y. T., Liu, X., Zhou, B., & Dai, T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1658826 · Cited by 7
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Mailhol, C., & Didier, A. P. (2012) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.22357 · Cited by 6
Grass pollen immunotherapy for treatment of allergic rhinitis
Slovick, A. D., Durham, S. R., & Till, S. J. (2014) · BMJ · doi:10.1136/bmj.g6586 · Cited by 6
Self-citationSlovick, A. D., Douiri, A., Kelly, J., Guerra, A., Muir, R., Tsioulos, K., Murphy, C., Shamji, M. H., Sun, Y., Durham, S. R., et al. (2013) · Clinical and Translational Allergy · doi:10.1186/2045-7022-3-27 · Cited by 6
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Alcaide, E. G., Mayorga, C., Gómez, F., Blázquez, A.-B., Díaz‐Perales, A., Blanca, M., & Torres, M. J. (2013) · Immunotherapy · doi:10.2217/imt.13.63 · Cited by 6
Cohen‐Kettenis, P. T., & de Vries, A. L. C. (2013) · Pure Amsterdam UMC · Cited by 6
Klimek, L., Brehler, R., Hamelmann, E. H., Kopp, M., Ring, J., Treudler, R., Jakob, T., Worm, M., & Pfaar, O. (2019) · Allergo Journal · doi:10.1007/s15007-019-1819-8 · Cited by 6
Cheng, S., Wen, S., Xie, S., Zhang, C., Zhang, H., Gao, K., Fan, R., Xie, Z., & Jiang, W. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.872152 · Cited by 6
Allergen immunotherapy for respiratory allergies in clinical practice: A comprehensive review
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Zhao, J., Li, C.-P., Zhao, B., Xu, P., Xu, H. C., & He, L. (2015) · PubMed Central · Cited by 6
Use of specific immunotherapy – a survey of 15 164 employed persons in Germany
Weberschock, T. B., Schaefer, I., Heigel, H., Valesky, E. M., Augustin, M., & Schmitt, J. M. (2014) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.12298 · Cited by 6
Congruence between international guidelines and mite specific immunotherapy prescribing practices
Antonicelli, L., Braschi, M. C., Bil, C., Angino, A., Pala, A. P., Baldacci, S., Maio, S., & Bonifazi, F. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.05.003 · Cited by 6
Timothy Grass Pollen Therapeutic Vaccine: Optimal Dose for Subcutaneous Immunotherapy
Sola, J., Ferreira, J. A., Elera, J. D., Plácido, J. L., Pereira, C., Fonseca, J., Panizo, C., Inácio, L. F., Cancelleire, N., Zubeldia, J. M., et al. (2016) · Immunotherapy · doi:10.2217/imt.15.125 · Cited by 6
Orphan immunotherapies for allergic diseases
Ridolo, E., Montagni, M., Incorvaia, C., Senna, G., & Passalacqua, G. (2016) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2015.12.031 · Cited by 6
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Malling, H., Corren, J., & Creticos, P. S. (2012) · Elsevier eBooks · doi:10.1016/b978-0-7234-3658-4.00012-3 · Cited by 6
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Baroody, F. M., & Naclerio, R. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-323-05283-2.00041-0 · Cited by 6
Intradermal Allergen Immunotherapy for Allergic Rhinitis: Current Evidence
Atipas, K., Kanjanawasee, D., & Tantilipikorn, P. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12081341 · Cited by 6
Matsuda, M., Shimizu, S., Kitatani, K., & Nabe, T. (2022) · Pathogens · doi:10.3390/pathogens11111373 · Cited by 6
Slovick, A. D., Douiri, A., Muir, R., Guerra, A., Tsioulos, K., Haye, E., Lam, E. P. S., Kelly, J., Peacock, J. L., Ying, S., et al. (2016) · Efficacy and Mechanism Evaluation · doi:10.3310/eme03100 · Cited by 6
Self-citationBurton, M. J., Krouse, J. H., & Rosenfeld, R. M. (2007) · Otolaryngology · doi:10.1016/j.otohns.2007.02.024 · Cited by 6
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Calderón, M. A., Boyle, R. J., Nankervis, H., Núñez, I. G., Williams, H. C., & Durham, S. R. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008774 · Cited by 6
Self-citationSchendzielorz, P., & Klimek, L. (2013) · HNO · doi:10.1007/s00106-013-2730-3 · Cited by 5
Bona, D. D., Carlucci, P., Spataro, F., Paoletti, G., Cognet-Sicé, J., Scurati, S., & Canonica, G. W. (2024) · Journal of Allergy and Clinical Immunology Global · doi:10.1016/j.jacig.2024.100208 · Cited by 5
Treatment of respiratory allergy with allergy immunotherapy tablets
Bachert, C. (2011) · Allergy · doi:10.1111/j.1398-9995.2011.02642.x · Cited by 5
Ivanova, J. I., Kelkar, S. S., King, S. B., Birnbaum, H. G., Hocker, S., Phipps, R. J., & Lankow, R. (2015) · Journal of Medical Economics · doi:10.3111/13696998.2015.1061533 · Cited by 5
Mühlmeier, G., & Maier, H. (2013) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-013-2609-7 · Cited by 5
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Song, Y., & Yan, Z. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.8213 · Cited by 5
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für die Österreichische Gesellschaft für Kinder, J., Szépfalusi, Z., Emminger, W., Eitelberger, F., Götz, M., Grillenberger, A., Horak, E., Huttegger, I., Koller, D. Y., Litscher, H., et al. (2009) · Wiener klinische Wochenschrift · doi:10.1007/s00508-009-1258-8 · Cited by 5
Hoover, H., Leatherman, B. D., Ryan, M. W., McMains, K. C., & Veling, M. C. (2018) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22118 · Cited by 5
Osguthorpe, J. D. (2010) · Current Opinion in Otolaryngology & Head & Neck Surgery · doi:10.1097/moo.0b013e3283385881 · Cited by 5
Yong, H., Di, L., Wang, Z., Yang, J., Yang, P., & Gao, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1560295 · Cited by 4
Spezifische Immuntherapie im Kindesalter
Kopp, M., & Bendiks, M. (2013) · Monatsschrift Kinderheilkunde · doi:10.1007/s00112-012-2804-4 · Cited by 4
Immunotherapy: Current indications and recommendations in the management of ocular allergy
Mahesh, P. A., Samajdar, S. S., Nagarajan, S. A., Murthy, G. M. V., & Moitra, S. (2024) · Indian Journal of Ophthalmology · doi:10.4103/ijo.ijo_2853_23 · Cited by 4
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Wedi, B. (2008) · Der Hautarzt · doi:10.1007/s00105-008-1491-5 · Cited by 4
Pollen-food syndrome involving allergy to tiger nut.
González‐de‐Olano, D., Gonzalez-Mancebo, E., Mohedano-Vicente, E., Gandolfo-Cano, M., & Bartolomé, B. (2013) · PubMed · Cited by 4
Patient characteristics in German allergological practices – a nationwide survey
Reinhold, T., Lindig, C., Willich, S. N., & Brüggenjürgen, B. (2018) · Allergologie select · doi:10.5414/alx01348e · Cited by 4
Campisi, L., Yong, P. F. K., Kasternow, B., & Karim, M. Y. (2020) · Allergy & Rhinology · doi:10.1177/2152656720943822 · Cited by 4
trEatmEnt of allErGic rhinitis
Seedat, R. Y. (2013) · Cited by 4
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Terada, T., & Kawata, R. (2022) · Allergies · doi:10.3390/allergies2010003 · Cited by 4
Soyyiğit, Ş., Aydın, O., Seçil, D., Doğan, C., Gökmen, D., Sin, B. A., Mısırlıgil, Z., & MUNGAN, V. D. (2022) · European Annals of Allergy and Clinical Immunology · doi:10.23822/eurannaci.1764-1489.252 · Cited by 4
An update on the management of hay fever in adults
(2013) · Drug and Therapeutics Bulletin · doi:10.1136/dtb.2013.1.0166 · Cited by 4
Actual therapeutic management of allergic and hyperreactive nasal disorders.
Rudack, C. (2004) · PubMed Central · Cited by 4
Steveling, E. H., Lao‐Araya, M., Koulias, C., Scadding, G. W., Eifan, A. O., James, L. K., Dumitru, A., Penagos, M., Calderón, M. A., Andersen, P. S., et al. (2015) · Clinical and Translational Allergy · doi:10.1186/s13601-015-0087-2 · Cited by 4
Self-citationSevere asthma and allergy: mechanisms, diagnostics and treatment
Hedlin, G., & van Hage, M. (2012) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02557.x · Cited by 4
House Dust Mite Immunotherapy in Iraqi Patients with Allergic Rhinitis and Asthma
Mohamad, A., Alobaidi, A. H. A., Mezher, S., & Mohamed, A. (2012) · InTech eBooks · doi:10.5772/47942 · Cited by 4
Linneberg, A. R., & Bødtger, U. C. S. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01359.x · Cited by 4
Cochrane Review: Sublingual immunotherapy for treating allergic conjunctivitis
Calderón, M. A., Penagos, M., Sheikh, A., Canonica, G. W., & Durham, S. R. (2012) · Evidence-Based Child Health A Cochrane Review Journal · doi:10.1002/ebch.1851 · Cited by 4
Self-citationThe perception of allergen-specific immunotherapy among chest physicians: an Italian survey.
Lombardi, C., Canonica, G. W., & Passalacqua, G. (2014) · PubMed · Cited by 4
▼Grazax for hay fever – what’s new?
(2010) · Drug and Therapeutics Bulletin · doi:10.1136/dtb.2009.12.0062 · Cited by 4
Immunotherapy for Allergic Disease
Matsui, E. C., & Eggleston, P. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-29875-9.00023-9 · Cited by 4
Fox, R. W., & Lockey, R. F. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-382-0_26 · Cited by 4
Mullins, R. J., Katelaris, C. H., & Rimmer, J. (2010) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2010.tb03681.x · Cited by 4
Santaolalla, M., Arias-Irigoyen, J., Soler, J. M., Duque, J. M., Escudero, R., Pérez‐Formoso, J. L., Lobera, T., Rueda, M., Alías, C., Hermida, H., et al. (2024) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2024.2373886 · Cited by 3
The efficacy assessment of a self‐administered immunotherapy protocol
Schaffer, F. M., Garner, L. M., Ebeling, M. D., Adelglass, J. M., Hulsey, T. C., & Naples, A. R. (2015) · International Forum of Allergy & Rhinology · doi:10.1002/alr.21653 · Cited by 3
Mechanism of Regulatory T Cells During Allergen-Specific Immunotherapy: from the Past to Future
Tsai, Y. (2012) · Journal of Allergy & Therapy · doi:10.4172/2155-6121.s7-005 · Cited by 3
Jahnz‐Różyk, K., Targowski, T., Owczarek, W. D., Przekora, P., Kucharczyk, A., & Wesołowski, A. (2011) · Cited by 3
Biologicals in der Rhinologie – Individualisierte Konzepte der Zukunft
Chaker, A. M. (2018) · Laryngo-Rhino-Otologie · doi:10.1055/s-0043-123484 · Cited by 3
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Dayasiri, K. C., Thadchanamoorthy, V., & Umasunthar, T. (2020) · International Journal of Human and Health Sciences (IJHHS) · doi:10.31344/ijhhs.v5i2.253 · Cited by 3
Oh, J. (2023) · Springer eBooks · doi:10.1007/978-981-99-4645-7_7 · Cited by 3
Conti, D. M., Backer, V., Kirsten, B., Bjermer, L. H., Chaker, A. M., Dramburg, S., Gaga, M., Gappa, M., Gevaert, P., Hamelmann, E. H., et al. (2024) · Pediatric Allergy and Immunology · doi:10.1111/pai.14183 · Cited by 3
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Braun, J. J., Devillier, P., Wallaert, B., Rancé, F., Jankowski, R., Acquaviva, J.-T., Beley, G., & Demoly, P. M. (2010) · Revue française d'allergologie · doi:10.1016/s1877-0320(10)70003-8 · Cited by 3
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Ferrer, M., Sanz, M. L., Gastaminza, G., del Pozo, V., de Souza, J., & Irache, J. M. (2012) · Anales del Sistema Sanitario de Navarra · doi:10.4321/s1137-66272012000100005 · Cited by 2
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Félix, M., Paz, C. V., Mata, V. L., Vanegas, E., Larenas‐Linnemann, D. E., Filho, N. A. R., Letort, J. J., & Chérrez-Ojeda, I. (2020) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s269531 · Cited by 2
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Pfützner, W. (2015) · International Archives of Allergy and Immunology · doi:10.1159/000375406 · Cited by 2
Metadata
- Authors
- Calderon, M. A., Alves, B., Jacobson, M., Hurwitz, B., Sheikh, A., & Durham, S.
- Affiliations
- Royal Brompton Hospital; Department of Allergy and Respiratory Medicine; Imperial College School of Medicine at the National Heart and Lung Institute London UK SW3 6LY
- Brighton and Hove City Council (GB)
- Imperial College London (GB)
- King's College London (GB)
- University of Edinburgh (GB)
- Royal Brompton Hospital (GB)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2007-01-24
- Volume
- 2009
- Issue
- 1
- Pages
- CD001936-CD001936
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- PMC
- PMC7017974
- OpenAlex
- W2153011983
- Cited by
- 678
- References
- 321
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 17 · 2023: 20 · 2022: 31 · 2021: 14 · 2020: 19 · 2019: 24 · 2018: 34 · 2017: 38 · 2016: 41 · 2015: 53 · 2014: 51 · 2013: 50 · 2012: 53
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Keywords
- allergen immunotherapy, allergic rhinitis, tree pollen, grass pollen, weed pollen, symptom scores, medication use, quality of life, adverse events, placebo comparison, treatment efficacy and safety, treatment duration, allergen sensitivity, allergen avoidance, allergen desensitization, allergen tolerance
- MeSH terms
- Allergens, Desensitization, Immunologic, Rhinitis, Allergic, Seasonal, Humans, Injections, Subcutaneous, Pollen, Randomized Controlled Trials as Topic
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