The DOI matches its Crossref record; 26 of the 28 references it cites were found in a registry or an index.
Multidisciplinary rehabilitation for fibromyalgia and musculoskeletal pain in working age adults
Open accessAbstract
BACKGROUND: Non-malignant musculoskeletal pain is an increasing problem in western countries. Fibromyalgia syndrome is an increasing recognised chronic musculoskeletal disorder. OBJECTIVES: The objective of this systematic review was to determine the effectiveness of multidisciplinary rehabilitation for fibromyalgia and widespread musculoskeletal pain among working age adults. SEARCH STRATEGY: An electronic search was conducted and included Medline from 1966, PsycLIT from 1967 and EMBASE from 1980 to April 1998. The Cochrane Musculoskeletal Group Trials Register was searched as well as, the Cochrane Controlled Trials Register (CCTR). The references of identified articles and reviews were checked, studies published in the Finnish medical database Medic from 1978 to 1998 screened and the Science Citation Index searched. Content experts were also contacted for additional or unpublished studies. SELECTION CRITERIA: From all references found in our original search, we selected all randomized controlled trials (RCTs) and clinical controlled trials (CCTs). Trials had to assess the effectiveness of multidisciplinary rehabilitation for patients suffering from fibromyalgia and widespread musculoskeletal pain among working age adults. The rehabilitation program was required to be multidisciplinary; that is, it had to consist of a physician's consultation, plus a psychological, social or vocational intervention, or a combination of both. DATA COLLECTION AND ANALYSIS: Four reviewers independently selected the RCTs and CCTs that met the specified inclusion criteria. Two experts in the field of rehabilitation evaluated the relevance and applicability of the findings of the selected studies to actual clinical use. Two other reviewers extracted the data and assessed the main results and the methodological quality of the studies using standardized forms. Finally, a qualitative analysis was performed to evaluate the level of scientific evidence for the effectiveness of multidisciplinary rehabilitation. MAIN RESULTS: After screening 1808 abstracts, and the references of 65 reviews, we found only seven relevant studies (1050 patients) that met our inclusion criteria. None of these were considered, methodologically, a high quality randomized controlled trial. Four of the included RCTs on fibromyalgia were graded low quality and suggest no quantifiable benefits. The three included RCTs on widespread musculoskeletal pain showed that based on limited evidence, overall, no evidence of efficacy was observed. However, behavioral treatment and stress management appear to be important components. Education combined with physical training showed some positive effects in long term follow up. REVIEWER'S CONCLUSIONS: We conclude that there appears to be little scientific evidence for the effectiveness of multidisciplinary rehabilitation for these musculoskeletal disorders. However, multidisciplinary rehabilitation is a commonly used intervention for chronic musculoskeletal disorders, which cause much personal suffering and substantial economic loss to the society. There is a need for high quality trials in this field.
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“The short-term effects are well established, but concerns about the long-term effects have been raised [7-11].”
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“Nevertheless, the results of the long-term effects of multidimensional pain programs are inconclusive and the need for maintenance support has been clearly stated [65,8,11,12].”
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Cites
Improving the Quality of Reporting of Randomized Controlled Trials: The CONSORT Statement
Begg, C. (1996) · JAMA · doi:10.1001/jama.1996.03540080059030 · Cited by 3,127
Systematic Reviews: Identifying relevant studies for systematic reviews
Dickersin, K., Scherer, R. W., & Lefebvre, C. (1994) · BMJ · doi:10.1136/bmj.309.6964.1286 · Cited by 2,255
Efficacy of multidisciplinary pain treatment centers: a meta-analytic review.
Flor, H., Fydrich, T., & Turk, D. C. (1992) · Pain · doi:10.1016/0304-3959(92)90145-2 · Cited by 1,227
van Tulder, M. W., Assendelft, W. J., Koes, B. W., & Bouter, L. M. (1997) · Spine · doi:10.1097/00007632-199710150-00001 · Cited by 727
Self-citationExercise Therapy for Low Back Pain
van Tulder, M. W., Malmivaara, A. V., Esmail, R., & Koes, B. W. (2000) · Spine · doi:10.1097/00007632-200011010-00011 · Cited by 560
Self-citationBurckhardt, C. S., Mannerkorpi, K., Hedenberg, L., & BJELLE, A. O. (1994) · PubMed · Cited by 393
Effects of Aerobic Exercise Versus Stress Management Treatment in Fibromyalgia
Wigers, S. H., Stiles, T. C., & Vogel, P. A. (1996) · Scandinavian Journal of Rheumatology · doi:10.3109/03009749609069212 · Cited by 328
Physiotherapy exercises and back pain: a blinded review.
Koes, B. W., Bouter, L. M., Beckerman, H., van der Heijden, G. J. M. G., & Knipschild, P. G. (1991) · BMJ · doi:10.1136/bmj.302.6792.1572 · Cited by 238
Self-citation(1996) · PubMed · Cited by 234
Group treatment of fibromyalgia: a 6 month outpatient program.
Bennett, R. M., Burckhardt, C. S., Clark, S. R., O'Reilly, C. A., Wiens, A. N., & Campbell, S. M. (1996) · PubMed · Cited by 210
Flagged first, then by citations
2 of the 28 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Guzman, Multidisciplinary team approaches for the treatment of chronic low back pain, (Cochrane review in process)
- Mulrow, 1996-Updated quarterly, Cochrane Collaboration Handbook (updated 1 March 1997), In: The Cochrane Library (database on disk and CDROM). The Cochrane Collaboration. Oxford: Update Software;
Cited by
Sorted by citations
Items 101–180 of 180
Psychosomatische Aspekte in Diagnostik und Therapie der Fibromyalgie
Blumenstiel, K., & Eich, W. (2003) · Der Schmerz · doi:10.1007/s00482-003-0248-4 · Cited by 10
Fibromyalgie: eine Stress bedingte Schmerzerkrankung?
Egle, U. T., & Houdenhove, B. V. (2006) · Der Schmerz · doi:10.1007/s00482-006-0479-2 · Cited by 10
The use of complementary and alternative therapies for fibromyalgia
Hardy-Pickering, R., Adams, N., Sim, J., Roe, B. H., & Wallymahmed, A. H. (2007) · Physical Therapy Reviews · doi:10.1179/108331907x222930 · Cited by 8
How to manage musculoskeletal conditions: when is ‘Rehabilitation’ appropriate?
Cameron, I. D. (2004) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2004.03.010 · Cited by 8
Predictors for health improvement in patients with fibromyalgia: a 2-year follow-up study
van Eijk‐Hustings, Y., Kroese, M., Boonen, A. E. R. C. H., Bessems-Beks, M., & Landewé, R. (2013) · Clinical Rheumatology · doi:10.1007/s10067-013-2371-7 · Cited by 9
Fibromyalgie und Leistungseinschränkung
Egle, U. T., Derra, C., Gruner, B., Käppis, B., Köllner, V., Maatz, E., Schoof, M., Schubert, U., & Schwab, R. (2007) · Psychotherapeut · doi:10.1007/s00278-007-0562-x · Cited by 7
Evidence-based integrative pain medicine
Rehberg, B. (2010) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2010.06.001 · Cited by 7
Saltychev, M. (2012) · UTUPub (University of Turku) · Cited by 7
Colle, F. M. C., Poiraudeau, S., & Revel, M. (2001) · Annales de Réadaptation et de Médecine Physique · doi:10.1016/s0168-6054(01)00093-9 · Cited by 7
Outcomes in Two Post-Acute Non-Inpatient Rehabilitation Settings
Bode, R. K., Heinemann, A. W., Zahara, D., & Lovell, L. L. (2007) · Topics in Stroke Rehabilitation · doi:10.1310/r18t-t048-8203-7211 · Cited by 6
Peoples’ experiences of painful diabetic neuropathy: are pain management programmes appropriate?
Davies, B. R., Cramp, F. L., Gauntlett‐Gilbert, J., & McCabe, C. (2021) · British Journal of Pain · doi:10.1177/2049463721989753 · Cited by 4
Musculoskeletal Pain- Moving from Symptoms and Syndromes to Mechanisms
Kumar, S. P. (2011) · Cited by 5
Intérêt d’une prise en charge plurimodale et pluridisciplinaire du patient fibromyalgique
Guy-Coichard, C., Cabané, J., Berenbaum, F., & Boureau, F. (2003) · Revue du Rhumatisme · doi:10.1016/s1169-8330(03)00108-x · Cited by 5
Efficacy of Farabloc as an analgesic in primary fibromyalgia
Bach, G. L., & Clement, D. B. (2007) · Clinical Rheumatology · doi:10.1007/s10067-006-0494-9 · Cited by 5
Zaina, F., & Négrini, S. (2008) · PubMed · Cited by 5
Norrefalk, J. (2006) · Figshare · Cited by 5
Löfgren, M., Schult, M., Öhman, A., Julin, P., & Ekholm, J. (2015) · Handbooks in health, work, and disability · doi:10.1007/978-1-4899-7627-7_26 · Cited by 4
Preliminary study: quantification of chronic pain from physiological data
Cheng, Z., Ly, F. S., Santander, T., Turki, E., Zhao, Y., Yoo, J., Lonergan, K., Gray, J., Li, C. H., Yang, H. T. Y., et al. (2022) · PAIN Reports · doi:10.1097/pr9.0000000000001039 · Cited by 4
Wagner, F., Janzen, B. L., Tkachuk, G. A., Laverty, W. H., & Woods, M. P. (2011) · Journal of Musculoskeletal Pain · doi:10.3109/10582452.2011.582985 · Cited by 4
Dickens, C. M., & Ash, G. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511543975.023 · Cited by 4
Fibromyalgia and Diffuse Myalgia
GILL, J., & Quisel, A. (2005) · Clinics in Family Practice · doi:10.1016/j.cfp.2005.02.011 · Cited by 4
Page, L., & Wessely, S. C. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511543975.008 · Cited by 4
van Galen, G. P. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511543579.223 · Cited by 4
(2010) · Drug and Therapeutics Bulletin · doi:10.1136/dtb.2010.08.0042 · Cited by 4
Fibromialgia: Abordagem terapêutica
Familiar, A. D. M. G. E., Gomes, P., Campos, C., & Familiar, M. I. D. M. G. E. (2010) · Revista Portuguesa de Clínica Geral · doi:10.32385/rpmgf.v26i2.10728 · Cited by 4
Multiprofessional rehabilitation for women with fibromyalgia : Quantitative and qualitative studies
Löfgren, M. (2006) · Figshare · Cited by 4
Principes de prise en charge d'une douleur chronique
Guillemet, G., & Guy-Coichard, C. (2016) · Time to knit · doi:10.1016/s1283-0887(15)65784-x · Cited by 3
Orofacial Muscle Pain: New Advances in Concept and Therapy
Lotaif, A. C., Mitrirattanakul, S., & Clark, G. T. (2006) · Journal of the California Dental Association · doi:10.1080/19424396.2006.12222231 · Cited by 3
Suoyrjö, H., Oksanen, T., Hinkka, K., Pentti, J., Mika Kivimaki, B., Klaukka, T., & Vahtera, J. (2009) · European Journal of Pain · doi:10.1016/s1090-3801(09)60520-6 · Cited by 3
Das Fibromyalgiesyndrom eine Übersicht und Standortbestimmung
Blumenstiel, K., Bieber, C. S., Raspe, H.-H., & Eich, W. (2003) · Zeitschrift für Medizinische Psychologie · doi:10.3233/zmp-2003-12_1_07 · Cited by 3
Pain rehabilitation in Sweden : a quality registry study
Nyberg, V. (2011) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 3
Harten, P. (2007) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-007-0216-y · Cited by 3
Rick, J., Carroll, C. P., Hillage, J., Pilgrim, H., & Jagger, N. (2008) · Cited by 3
Benz, T., Lehmann, S., Sándor, P. S., & Angst, F. (2025) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-025-09270-y · Cited by 3
Zaina, F., & Négrini, S. (2012) · PubMed · Cited by 2
Latorre-Santiago, D., & Torres-Lacomba, M. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 4
Principios de tratamiento del dolor crónico
Guillemet, G., & Guy-Coichard, C. (2016) · EMC - Kinesiterapia - Medicina Física · doi:10.1016/s1293-2965(16)78902-x · Cited by 2
Approche pluridisciplinaire de la fibromyalgie (FM)
Bendaya, S., Breton, F. L., Gahlouz, F., & Aymard, C. (2007) · La Lettre de médecine physique et de réadaptation · doi:10.1007/s11659-007-0066-7 · Cited by 2
Pain rehabilitation – outcome of an 8-week rehabilitation program
Norrefalk, J., & Borg, K. (2012) · SHS Web of Conferences · doi:10.1051/shsconf/20120200007 · Cited by 2
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Smeets, R. (2011) · Océ Business Services eBooks · doi:10.26481/spe.20110401rs · Cited by 1
Zaina, F., & Négrini, S. (2011) · PubMed · Cited by 1
Lacassie, Q. H. (2014) · Revista Médica Clínica Las Condes · doi:10.1016/s0716-8640(14)70085-9 · Cited by 1
Interprofessional pain learning and working: different perspectives
Karargyri, D. (2012) · British Journal of Pain · doi:10.1177/2049463712443453 · Cited by 1
Murad, M. S., Farnworth, L., O’Brien, L., & Chien, C. (2012) · Monash University Research Portal (Monash University) · Cited by 1
Speciální pedagogika osob s omezením pohyblivosti a koncept praxe založené na důkazech
Kameník, J. (2023) · doi:10.5507/pdf.23.24462745 · Cited by 1
Multidisciplinary Pain Clinic Treatment
Tunks, E. (2008) · Health care and disease management · doi:10.1002/9783527622665.ch12 · Cited by 1
Multidisciplinair programma voor fibromyalgie in de eerste lijn
Oeseburg, B., van Wilgen, P., & Bloten, H. (2005) · Stimulus · doi:10.1007/bf03076117 · Cited by 1
Cherry, L. S., Crossland, V., Field, R., Ainsworth, P., & Edwards, C. J. (2014) · Lara D. Veeken · doi:10.1093/rheumatology/keu106.012 · Cited by 1
Uit de kliniek Chronische rugklachten, pijnrevalidatie en arbeid
Preuper, H. R. S., Geertzen, J. H. B., & Reneman, M. F. (2009) · Tijdschrift voor bedrijfs- en verzekeringsgeneeskunde · doi:10.1007/bf03081194 · Cited by 1
Evaluation of health care innovations in fibromyalgia
Kroese, M. (2012) · doi:10.26481/dis.20121101mk · Cited by 1
Blumenstiel, K., Bieber, C. S., & Eich, W. (2004) · Springer eBooks · doi:10.1007/978-3-662-09587-4_24 · Cited by 1
Portzky, F. (2010) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.11436
Physikalische Therapie und Rehabilitation bei Schmerzsyndromen am Bewegungsapparat
Vacariu, G., Schuhfried, O., & Korpan, M. I. (2013) · Springer eBooks · doi:10.1007/978-3-7091-0467-5_25
Physikalische Therapie und Rehabilitation bei Schmerzsyndromen
Vacariu, G., Schuhfried, O., & Korpan, M. I. (2005) · Springer eBooks · doi:10.1007/3-211-28107-x_16
Hoeps, K., & Velthuis, M. J. (2008) · Stimulus · doi:10.1007/bf03077585
Revalidatiegeneeskunde, een kwestie van goed schakelen
Smeets, R. (2012) · Bijblijven · doi:10.1007/s12414-012-0046-y
From Diagnosis to Treatment of Muscular Dystrophy: Psychology Meets Medicine
Ismail, E. H. C., & Othman, N. (2015) · International Journal of Psychological Studies · doi:10.5539/ijps.v8n1p85
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Gross, W. L., & Moosig, B. F. (2008)
Conditions associated with fibromyalgia
Chaitow, L., Baldry, P., Blake, E., Dommerholt, J., Good, R., Issa, T. S., Lowe, J. C., McMakin, C., McPartland, J. M., Watson, P., et al. (2009) · Elsevier eBooks · doi:10.1016/b978-0-443-06936-9.00003-2
Lacassie, H. J., & Muir, H. A. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511544552.013
Determinants of disability and functional capacity in patients with chronic low back pain
Preuper, H. R. S. (2011)
Musculoskeletal conditions, part 1: rheumatological disorders
Nasir, S. A. R., & Walker-Bone, K. E. (2019) · doi:10.1093/med/9780198808657.003.0020
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Mindeberg, R. B. (2020) · Sykepleien Forskning · doi:10.4220/sykepleiens.2020.80924
Miedema, H. S. (2004) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-7316-1_50
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Guillemet, G., & Guy-Coichard, C. (2020) · EMC - Medicina Riabilitativa · doi:10.1016/s1283-078x(20)44352-4
(2011) · Elsevier eBooks · doi:10.1016/b978-0-7295-3908-1.10016-8
(2016) · Elsevier eBooks · doi:10.1016/b978-3-437-21833-0.16001-2
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Zijlstra, T. R. (2007) · doi:10.3990/1.9789036525558
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Guillemet, G. (2025) · EMC - Kinesiterapia - Medicina Física · doi:10.1016/s1293-2965(25)50348-1
Patel, J. I., Raja, P., Sivaranjani, Jeyakumar, S., & Rao, P. A. (2025) · International Journal of Allied Medical Sciences and Clinical Research · doi:10.61096/ijamscr.v13.iss1.2025.51-55
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Guillemet, G. (2025) · EMC - Medicina Riabilitativa · doi:10.1016/s1283-078x(25)50365-6
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van Eijk‐Hustings, Y. (2014) · doi:10.26481/dis.20140313ye
Jung, A., Balzer, J., Braun, T., & Luedtke, K. (2022) · Figshare · doi:10.6084/m9.figshare.19533921
Jung, A., Balzer, J., Braun, T., & Luedtke, K. (2022) · Figshare · doi:10.6084/m9.figshare.19533918
Jung, A., Balzer, J., Braun, T., & Luedtke, K. (2022) · Figshare · doi:10.6084/m9.figshare.19533927
Jung, A., Balzer, J., Braun, T., & Luedtke, K. (2022) · Figshare · doi:10.6084/m9.figshare.19533924
LIVING WITH FIBROMYALGIA (FM): THE SALIENCE OF CLINICAL SUBGROUPS
Breland, H. L. (2006) · D-Scholarship@Pitt (University of Pittsburgh)
Metadata
- Authors
- Karjalainen, K. A., Malmivaara, A., van Tulder, M. W., Roine, R., Jauhiainen, M., Hurri, H., & Koes, B. W.
- Affiliations
- Finnish Institute of Occupational Health (FI)
- Finnish Office for Health Care Technology Assessment; Occupational Medicine; Lintulahdenkuja 4 Helsinki Finland FIN-00530
- Faculty of Earth & Life Sciences, VU University; Department of Health Economics & Health Technology Assessment, Institute of Health Sciences; De Boelelaan 1081, room U443 Amsterdam Netherlands 1081 HV
- Helsinki University Hospital (FI)
- Tekonivelsairaala Orton (FI)
- Erasmus MC (NL)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 1999-07-26
- Volume
- 2010
- Issue
- 1
- Pages
- CD001984-CD001984
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- PMC
- PMC8409280
- OpenAlex
- W2123364617
- Cited by
- 180
- References
- 28
- Citations by year
- 2025: 5 · 2023: 2 · 2022: 8 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 11
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- VU Research Portal (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
- Keywords
- fibromyalgia, chronic widespread pain, multidisciplinary rehabilitation, working-age adults, treatment effectiveness, behavior therapy, stress management, patient education, exercise training, psychological intervention, vocational interventions, chronic pain, methodological quality of trials, long-term outcomes, rehabilitation funding
- MeSH terms
- Adult, Chronic Disease, Fibromyalgia, Humans, Musculoskeletal Diseases, Pain, Pain Management
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