Cited by 120Nutrition and Health in AgingClinical Nutrition and GastroenterologyNutrition and Health Studies

Protein and energy supplementation in elderly people at risk from malnutrition

Milne, Anne C, Potter, Jan, Avenell, Alison·2005·Cochrane Database of Systematic Reviews

Abstract

Background Evidence for the effectiveness of nutritional supplements containing protein and energy, which are often prescribed for older people, is limited. Furthermore malnutrition is more common in this age group and deterioration of nutritional status can occur during illness. It is important to establish whether supplementing the diet is an effective way of improving outcomes for older people at risk from malnutrition. Objectives This review examined the evidence from trials for improvement in nutritional status and clinical outcomes when extra protein and energy were provided, usually in the form of commercial 'sip-feeds'. Search strategy We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, Healthstar, CINAHL, BIOSIS, CAB abstracts. We also hand searched nutrition journals and reference lists and contacted 'sip-feed' manufacturers. Date of most recent search: March 2004. Selection criteria Randomised controlled trials and quasi-randomised controlled trials of oral protein and energy supplementation in older people with the exception of groups recovering from cancer treatment or in critical care. Data collection and analysis Two reviewers independently assessed trials prior to inclusion and independently extracted data and assessed trial quality. Authors of trials were contacted for further information as necessary. Main results Forty-nine trials with 4790 randomised participants have been included in the review. Most included trials…

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Crossref · 10.1002/14651858.cd003288.pub2

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  • Subgroup analysis in meta-analyses from Milne et al. 2002 and 2005 showed a consistently statistically significant impact of ONS on mortality when supplementation was continued for 35 days or more compared to less than 35 days.

    “Regarding the length of the intervention, subgroup analysis in the meta-analyses from Milne et al. from 2002 (117) and 2005 (118) showed a consistently statistically significant impact of ONS on mortality when supplementation was continued for 35 days or more compared to less than 35 days.”
  • A systematic literature search found six high-quality SLRs that have assessed the efficacy of ONS versus usual care in older persons.

    “A systematic literature search found six high-quality SLRs that have assessed the efficacy of ONS versus usual care in older persons (114-121).”

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References 184 · Cited by 120

Authors
Milne, A. C., Potter, J., & Avenell, A.
Affiliations
University of Aberdeen (GB)
Venue
Cochrane Database of Systematic Reviews
Published
2005-01-24
Issue
2
Pages
CD003288-CD003288
ISSN
1361-6137 (ISSN-L)
OpenAlex
W4241358619
Cited by
120
References
184
Citations by year
2025: 1 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 2 · 2012: 6
Type
reference entry
Language
en
Open access
closed
Locations
  • Cochrane Database of Systematic Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Keywords
protein supplementation, energy supplementation, malnutrition, older adults, nutritional status, weight gain, mortality, length of hospital stay, functional outcome, clinical outcomes, dietary supplements, cost-effectiveness, cost-benefit analysis
MeSH terms
Aged, Energy Intake, Dietary Proteins, Humans, Length of Stay, Nutrition Disorders, Randomized Controlled Trials as Topic, Dietary Supplements

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