Interventions to improve antibiotic prescribing practices for hospital inpatients
Open accessAbstract
Comparison 1 Effectiveness: Prescribing outcomes from RCTs of interventions to reduce unnecessary antibiotic use, Outcome 1 Dichotomous outcomes, increase in desired practice. . . . . . . . . . . .Analysis 1.2.Comparison 1 Effectiveness: Prescribing outcomes from RCTs of interventions to reduce unnecessary antibiotic use, Outcome 2 Dichotomous outcomes, all RCTs with results of cluster RCTs adjusted by inflation factor. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Analysis 1.3.Comparison 1 Effectiveness: Prescribing outcomes from RCTs of interventions to reduce unnecessary antibiotic use, Outcome 3 Dichotomous outcomes, low or medium 'Risk of bias' studies only. . . . . . .Analysis 1.4.Comparison 1 Effectiveness: Prescribing outcomes from RCTs of interventions to reduce unnecessary antibiotic use, Outcome 4 Continuous outcomes, duration of all antibiotic treatment (days). . . . . . .Analysis 1.5.Comparison 1 Effectiveness: Prescribing outcomes from RCTs of interventions to reduce unnecessary antibiotic use, Outcome 5 Continuous outcomes, duration of all antibiotic treatment with results of cluster RCTs adjusted by inflation factor. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Analysis 1.6.Comparison 1 Effectiveness: Prescribing outcomes from RCTs of interventions to reduce unnecessary antibiotic use, Outcome 6 Continuous outcomes, low or medium 'Risk of bias' studies only. . . . . . . .Analysis 1.7.Comparison 1 Effectiveness: Prescribing outcomes from RCTs of interventions to reduce unnecessary antibiotic use, Outcome 7 Continuous outcome, consumption of targeted antibiotic only, standardised mean reduction (original outcome cost, days or DDD). . . . . . . . . . . . . . . . . . . . . .Analysis 2.1.Comparison 2 Adverse effects: Clinical outcomes from RCTs of interventions to reduce unnecessary antibiotic use, Outcome 1 Mortality, all RCTs. . . . . . . . . . . . . . . . . . . . . . . . . . .Analysis 2.2.Comparison 2 Adverse effects: Clinical outcomes from RCTs of interventions to reduce unnecessary antibiotic use, Outcome 2 Mortality, all RCTs with results of cluster RCTs adjusted by inflation factor. . . . . . .Analysis 2.3.Comparison 2 Adverse effects: Clinical outcomes from RCTs of interventions to reduce unnecessary antibiotic use, Outcome 3 Mortality, low or medium 'Risk of bias' RCTs. . . . . . . . . . . . . . . . . .i Interventions to improve antibiotic prescribing practices for hospital inpatients (Review)
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Where AMS has been implemented in surgery, its focus remains on surgical antibiotic prophylaxis and prevention of surgical site infection.
“Where interventions such as AMS have been implemented in surgery, their focus remains on surgical antibiotic prophylaxis and prevention of surgical site infection (SSI).10,11”
From Rationalizing irrational prescribing—infection-related attitudes and practices across paediatric surgery specialties in a hospital in South India (2024) · cites this paper as [10]
The Event Description section reports that 11 included studies targeted surgical antibiotic prophylaxis, supporting that part of the claim. The review also discusses surgical-site infection as an outcome, but it does not establish that preventing it remains the focus of surgical stewardship interventions generally; the ITS studies section describes a prophylaxis change intended to reduce the risk of CDI instead. Page numbers are not available for these passages in our copy. (LLM, conf=0.85)
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- review.ti. 46 (rat or rats or cow or cows or chicken? or horse or horses or mice or mouse or bovine or animal?).ti. 47 exp animals/ not humans.sh. 48 (animal$ not human$).sh,hw.
- pre-workshop or post-workshop or (before adj3 workshop) or workshop)).ti,ab.
- random$.ti,ab. or controlled.ti. 24 review.ti. 25 or/12-23 26 25 not 24 27 11 and 26 Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library Issue 1 2015 (Searched 22 January 2015) #
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- Authors
- Davey, P., Marwick, C. A., Scott, C. L., Charani, E., McNeil, K., Brown, E., Gould, I. M., Ramsay, C. R., & Michie, S.
- Affiliations
- University of Dundee (GB)
- NHS Education for Scotland (GB)
- National Institute for Health and Care Research (GB)
- No affiliation; 31 Park Crescent Frenchay Bristol UK BS16 1NZ
- Aberdeen Royal Infirmary (GB)
- University of Aberdeen (GB)
- The Royal Free Hospital (GB)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2017-02-09
- Volume
- 2017
- Issue
- 2
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- OpenAlex
- W4294236078
- Cited by
- 1,068
- References
- 13
- Citations by year
- 2026: 63 · 2025: 75 · 2024: 106 · 2023: 108 · 2022: 132 · 2021: 137 · 2020: 161 · 2019: 121 · 2018: 101 · 2017: 59 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 12.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion, other-oa)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- National Institute for Health Research Health Protection Research Unit
- National Institute for Health and Care Research (13/89/04)
- Imperial College London
- Public Health England
- Patient Safety Translational Research Centre
- NIHR Imperial Biomedical Research Centre
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Health Sciences › Health Professions › General Health Professions › Healthcare cost, quality, practices
- Health Sciences › Medicine › Surgery › Surgical site infection prevention
- Keywords
- antibiotic prescribing, hospitalized patients, unnecessary antibiotic use, antimicrobial stewardship, prescribing interventions, antibiotic duration, mortality, risk of bias, cost-effectiveness, appropriateness of prescribing, appropriateness of antibiotic prescribing
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