Antidepressants for treating depression in dementia
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Antidepressants for treating depression in dementia (Review)
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The US Reducing Disability in Dementia study found increased physical activity, with days of taking 30 or more minutes of exercise showing an effect size of 0.6 (95% CI 0.4-0.8) after treatment and 0.3 (95% CI 0.1-0.5) at 13 months in a before-and-after comparison.
“The study found increased physical activity; days of taking 30 or more minutes of exercise (effect size 0·6, 95% CI 0·4–0·8 after the treatment and 0·3, 0·1–0·5 at 13 months) in a before and after intervention comparison.”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [209]
The Activities of daily living and Main results sections report antidepressant-versus-placebo outcomes, not exercise outcomes. Searches for “Reducing Disability in Dementia,” 30-minute exercise, and the stated effect sizes found no passage addressing the claimed before-and-after results at treatment completion or 13 months. Page numbers were not available in our copy. (LLM, conf=0.78)
Experimental — accuracy not yet measuredThe US Reducing Disability in Dementia study was able to follow up 140 (54.9%) of 255 participants.
“were able to follow up 140 (54·9%).”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [209]
The Included studies section describes antidepressant trials in dementia, but does not identify the US Reducing Disability in Dementia study. Searches for the study name and for 140, 255, and 54.9% found no passage reporting the claimed follow-up figure. Page numbers were not available in our copy. (LLM, conf=0.76)
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References 114 · Cited by 175
Research works printed but not linked: 8
- to studies in 2017 {published data only} An H, Choi B, Park K-W, Kim D-H, Yang D-W, Hong CH, et al. The effect of escitalopram on mood and cognition in depressive Alzheimer's disease subjects. Journal of Alzheimer's disease 2017;2:727-35.
- Romeo R, Knapp M, Hellier J, Dewey M, Ballard C, Baldwin R, et al. Cost-effectiveness analyses for mirtazapine and sertraline in dementia: randomised controlled trial. British Journal of Psychiatry 2013;202:121-8.
- de Vasconcelos 2007 {published data only} de Vasconcelos Cunha UG, Lopes Rocha F, Avila de Melo R, et al. A placebo-controlled double-blind randomized study of venlafaxine in the treatment of depression in dementia. Dementia & Geriatric Cognitive Disorders 2007; 24(1):36-41.
- Fuchs 1993 {published data only} Fuchs A, Hehnke CH, Erhart C, Schnell C, Pramshohler B, Danninger B, et al. Video rating analysis of effect of maprotiline in patients with dementia and depression. Pharmacopsychiatry 1993;26:37-41. References to studies excluded from this review Barak 1996 {published data only} Barak Y, Levine J, Glasman A, Elizur A, Belmaker RH. Inositol treatment of Alzheimer's disease: a double blind, cross-over placebo controlled trial. Progress in Neuro Psychopharmacology and Biological Psychiatry 1996;20(4): 729-36.
- Brodaty 2003 {published data only} Brodaty H, Draper BM, Millar J, Low LF, Lie D, Sharah S, et al. Randomized controlled trial of different models of care for nursing home residents with dementia complicated by depression or psychosis. Journal of Clinical Psychiatry 2003;64(1):63-72.
- Bui 2012 {published data only} Bui Q. Antidepressants for agitation and psychosis in patients with dementia. American Family Physician 2012;85 (1):20-2.
- Burke 1994 {published data only} Burke WJ, Folks DG, Roccaforte WH, Wengel SP. Serotonin reuptake inhibitors for the treatment of coexisting depression and psychosis in dementia of the Alzheimer type. American Journal of Geriatric Psychiatry 1994;2(4):352-4.
- Capote 1978 {published data only} Capote B, Parikh N. Cyclandelate in the treatment of senility: a controlled study. Journal of the American Geriatrics Society 1978;26(8):360-2. 12.4 older antidepressants 3 179 Odds Ratio (M-H, Fixed, 95% CI) 1.39 [0.69, 2.80] 13 Tolerability: Number of dropouts at 6-9 months 2 457 Odds Ratio (M-H, Fixed, 95% CI) 1.25 [0.83, 1.88]
- Authors
- Dudas, R., Malouf, R., McCleery, J., & Dening, T.
- Affiliations
- University of Cambridge (GB)
- University of Oxford (GB)
- Oxford Health NHS Foundation Trust (GB)
- University of Nottingham (GB)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2018-08-31
- Volume
- 2018
- Issue
- 8
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- OpenAlex
- W4211242662
- Cited by
- 175
- References
- 114
- Citations by year
- 2026: 12 · 2025: 25 · 2024: 26 · 2023: 27 · 2022: 26 · 2021: 19 · 2020: 21 · 2019: 18 · 2017: 1
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- Repository@Nottingham (University of Nottingham) (publishedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- antidepressants, depression, dementia, depression in dementia, pharmacotherapy
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