The DOI matches its Crossref record; its reference list is not available.
Pharmacological interventions for benzodiazepine dependence management among benzodiazepine users in outpatient settings
Abstract
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The objective of this study is to evaluate the effectiveness of pharmacological interventions for BZD dependence.
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A systematic review of 35 studies found the best results with a 10-week taper, though 31% still could not stop.
“A systematic review of 35 studies found the best results with a 10-week taper, though 31% still could not stop (Cantopher, Olivieri, Cleave, & Edwards, 1990; Denis, Fatseas, Lavie, & Auriacombe, 2005).”
From Pharmacological principles for safe benzodiazepine and Z-drug dose reduction (2026) · cites this paper as Denis, Fatseas, Lavie, & Auriacombe, 2005
Evidence does not strongly support or refute switching from shorter- to longer-acting benzodiazepines during tapering.
“Evidence does not strongly support or refute switching from shorter- to longer-acting benzodiazepines during tapering (Denis et al., 2005).”
From Pharmacological principles for safe benzodiazepine and Z-drug dose reduction (2026) · cites this paper as Denis et al., 2005
Citations
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References 18 · Cited by 3
Research works printed but not linked: 15
- Alderson P Green S Higgins JPT Cochrane Reviewers' Handbook [updated 2004] In: The Cochane Library [database on CDROM]. The Cochrane Collaboration. Chichester, UK: John Wiley & Sons, Ltd; 2004
- 1994, Diagnostical and Statistical Manual of Mental Disorders
- Kan, 1997, High prevalence of benzodiazepine dependence in out-patient users, based on the DSM-III-R and ICD-10 criteria, Acta Psychiatrica Scandinavica, 96, 85, 10.1111/j.1600-0447.1997.tb09911.x · DOI
- Kan, 1998, An evaluation of DSM-III-R and ICD-10 benzodiazepine dependence criteria using Rasch modelling, Addiction, 93, 349, 10.1046/j.1360-0443.1998.9333494.x · DOI
- Lader, 1991, Benzodiazepine problems, British Journal of Addiction, 86, 823, 10.1111/j.1360-0443.1991.tb01831.x · DOI
- Lehert, 1993, Review and discussion of statistical analysis of controlled clinical trials in alcoholism, Alcohol Alcohol supplement, 2, 157
- Lennane, 1986, Treatment of benzodiazepine dependence, Medical Journal of Australia, 144, 594, 10.5694/j.1326-5377.1986.tb112319.x · DOI
- Martin, 1982, Diazepam and pentobarbital dependence in the rat, Life Science, 31, 721, 10.1016/0024-3205(82)90697-X · DOI
- Moher, 1995, Meta-analysis of randomized controlled trials. A concern for standards, JAMA, 274, 1962, 10.1001/jama.1995.03530240072044 · DOI
- Rickels, 1988, Long-term treatment of anxiety and risk of withdrawal. Prospective comparison of clorazepate and buspirone, Archives of General Psychiatry, 45, 444, 10.1001/archpsyc.1988.01800290060008 · DOI
- Rickels, 1990, Benzodiazepine dependence: management of discontinuation, Psychopharmacology Bulletin, 26, 63
- Salzman, 1991, Long-term therapeutic use of benzodiazepines. II. Effects of gradual taper, American Journal of Psychiatry, 148, 151
- Schweizer, 1991, Carbamazepine treatment in patients discontinuing long-term benzodiazepine therapy. Effects on withdrawal severity and outcome, Archives of General Psychiatry, 48, 448, 10.1001/archpsyc.1991.01810290060012 · DOI · Paper page
- Winokur, 1980, Withdrawal reaction from long-term, low-dosage administration of diazepam. A double-blind, placebo-controlled case study, Archives of General Psychiatry, 37, 101, 10.1001/archpsyc.1980.01780140103012 · DOI
- Woods, 1992, Benzodiazepines: use, abuse, and consequences, Pharmacological Review, 44, 155
Metadata
- Authors
- Denis, C., Fatséas, M., Lavie, E., & Auriacombe, M.
- Affiliations
- Centre Hospitalier Charles Perrens (FR)
- Université Bordeaux Segalen (FR)
- Venue
- The Cochrane Database of Systematic Reviews
- Publisher
- John Wiley & Sons, Ltd
- Published
- 2005-04-20
- ISSN
- 1361-6137 (ISSN-L)
- OpenAlex
- W1497548654
- Cited by
- 3
- References
- 18
- Citations by year
- 2026: 1 · 2024: 2
- Type
- reference entry
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2013-06-18)
- Open access
- closed
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- benzodiazepine dependence, pharmacological interventions, benzodiazepine withdrawal, outpatient care, treatment effectiveness
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