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Cited by 212Posttraumatic Stress Disorder ResearchPsychotherapy Techniques and ApplicationsSleep and related disorders

The DOI matches its Crossref record; 71 of the 73 references it cites were found in a registry or an index.

Combined pharmacotherapy and psychological therapies for post traumatic stress disorder (PTSD)

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Hetrick, Sarah E, Purcell, Rosemary, Garner, Belinda, Parslow, Ruth·2010·Cochrane Database of Systematic Reviews
DOI 10.1002/14651858.cd007316.pub2PMC PMC12515543
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Abstract

BACKGROUND: PTSD is an anxiety disorder related to exposure to a severe psychological trauma. Symptoms include re-experiencing the event, avoidance and arousal as well as distress and impairment resulting from these symptoms.Guidelines suggest a combination of both psychological therapy and pharmacotherapy may enhance treatment response, especially in those with more severe PTSD or in those who have not responded to either intervention alone. OBJECTIVES: To assess whether the combination of psychological therapy and pharmacotherapy provides a more efficacious treatment for PTSD than either of these interventions delivered separately. SEARCH STRATEGY: Searches were conducted on the trial registers kept by the CCDAN group (CCDANCTR-Studies and CCDANCTR-References) to June 2010. The reference sections of included studies and several conference abstracts were also scanned. SELECTION CRITERIA: Patients of any age or gender, with chronic or recent onset PTSD arising from any type of event relevant to the diagnostic criteria were included. A combination of any psychological therapy and pharmacotherapy was included and compared to wait list, placebo, standard treatment or either intervention alone. The primary outcome was change in total PTSD symptom severity. Other outcomes included changes in functioning, depression and anxiety symptoms, suicide attempts, substance use, withdrawal and cost. DATA COLLECTION AND ANALYSIS: Two or three review authors independently selected trials, assessed their 'risk of bias' and extracted trial and outcome data. We used a fixed-effect model for meta-analysis. The relative risk was used to summarise dichotomous outcomes and the mean difference and standardised mean difference were used to summarise continuous measures. MAIN RESULTS: Four trials were eligible for inclusion, one of these trials (n =24) was on children and adolescents. All used an SSRI and prolonged exposure or a cognitive behavioural intervention. Two trials compared combination treatment with pharmacological treatment and two compared combination treatment with psychological treatment. Only two trials reported a total PTSD symptom score and these data could not be combined. There was no strong evidence to show if there were differences between the group receiving combined interventions compared to the group receiving psychological therapy (mean difference 2.44, 95% CI -2.87, 7.35 one study, n=65) or pharmacotherapy (mean difference -4.70, 95% CI -10.84 to 1.44; one study, n = 25). Trialists reported no significant differences between combination and single intervention groups in the other two studies. There were very little data reported for other outcomes, and in no case were significant differences reported. AUTHORS' CONCLUSIONS: There is not enough evidence available to support or refute the effectiveness of combined psychological therapy and pharmacotherapy compared to either of these interventions alone. Further large randomised controlled trials are urgently required.

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  1. Gamito, 2005, Virtual war PTSD--A methodological thread, Annual Review of CyberTherapy and Telemedicine, 3, 173
  2. Hicks PB Adams ML Litz B Young K Goldart J Velez T Penk W//Kotrla K Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure Military Health Research Forum, Kansas City, MO. August 31- September 3, 2009 [Conference Abstracts] 2009
  3. McAllister TW Fann J Chard K Venlafaxine and CBT for Psychological Distress After TBI: A Randomized Controlled Trial Military Health Research Forum, Kansas City, MO. August 31- September 3, 2009 [Conference Abstracts] 2009
  4. American Psychiatric Association, 1980, Diagnostic and Statistical Manual of Mental Disorders
  5. Spielberger, 1970, State-Trait Anxiety Inventory (Self-Evaluation Questionnaire)
  6. World Health Organisation, 1992, The Tenth Revision of the International Classification of Diseases and Related Health Problems (ICD-10)

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Metadata

Authors
Hetrick, S. E., Purcell, R., Garner, B., & Parslow, R.
Affiliations
The University of Melbourne (AU)
ORCID
Venue
Cochrane Database of Systematic Reviews
Publisher
Wiley
Published
2010-07-07
Volume
2010
Issue
7
Pages
CD007316-CD007316
ISSN
  • 1361-6137 (ISSN-L)
  • 1465-1858
DOI
10.1002/14651858.cd007316.pub2
PMC
PMC12515543
OpenAlex
W1796823137
Cited by
212
References
73
Citations by year
2026: 5 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 26 · 2021: 11 · 2020: 12 · 2019: 22 · 2018: 11 · 2017: 9 · 2016: 12 · 2015: 19 · 2014: 19 · 2013: 18 · 2012: 14
FWCI
1.96
Type
journal article
Language
en
Open access
Locations
  • Cochrane Database of Systematic Reviews (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed (publishedVersion)
  • QUT ePrints (Queensland University of Technology) (submittedVersion)
  • Swinburne figshare (Swinburne University of Technology) (submittedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
post-traumatic stress disorder, prolonged exposure therapy, cognitive behavioral therapy, selective serotonin reuptake inhibitors, PTSD symptom severity, anxiety and depressive symptoms, suicide attempts, substance use, treatment costs, children and adolescents, treatment response, risk of bias in trials, treatment cost-effectiveness, treatment relapse
MeSH terms
Adolescent, Adult, Child, Child Abuse, Sexual, Clonazepam, Combined Modality Therapy, Female, Humans, Male, Refugees, Stress Disorders, Post-Traumatic, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Selective Serotonin Reuptake Inhibitors, Paroxetine, Sertraline

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