Pharmacotherapy for anxiety and comorbid alcohol use disorders
Open accessAbstract
Background Anxiety disorders are a potentially disabling group of disorders that frequently co-occur with alcohol use disorders. Comorbid anxiety and alcohol use disorders are associated with poorer outcomes, and are difficult to treat with standard psychosocial interventions. In addition, improved understanding of the biological basis of the conditions has contributed to a growing interest in the use of medications for the treatment of people with both diagnoses. Objectives To assess the effects of pharmacotherapy for treating anxiety in people with comorbid alcohol use disorders, specifically: to provide an estimate of the overall effects of medication in improving treatment response and reducing symptom severity in the treatment of anxiety disorders in people with comorbid alcohol use disorders; to determine whether specific medications are more effective and tolerable than other medications in the treatment of particular anxiety disorders; and to identify which factors (clinical, methodological) predict response to pharmacotherapy for anxiety disorders. Search methods Review authors searched the specialized registers of The Cochrane Collaboration Depression, Anxiety and Neurosis Review Group (CCDANCTR, to January 2014) and the Cochrane Drugs and Alcohol Group (CDAG, to March 2013) for eligible trials. These registers contain reports of relevant randomized controlled trials (RCT) from: the Cochrane Central Register of Controlled Trials (CENTRAL, all years), MEDLINE (1950 t…
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Cochrane reviews have highlighted the potential utility of SSRIs in treating MDD, anxiety disorders, AUD, or combinations of these conditions in individuals with co-occurring AUD, with minimal risk of adverse effects.
“Cochrane reviews have highlighted the potential utility of SSRIs in treating MDD, anxiety disorders, AUD, or combinations of these conditions in individuals with co-occurring AUD, with minimal risk of adverse effects [63,64].”
From Navigating the Complex Intersection of Substance Use and Psychiatric Disorders: A Comprehensive Review (2024) · cites this paper as [64]
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- Authors
- Ipser, J. C., Wilson, D., Akindipe, T. O., Sager, C., & Stein, D. J.
- Affiliations
- University of Cape Town (ZA)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2015-01-20
- Volume
- 2020
- Issue
- 11
- Pages
- CD007505-CD007505
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- PMC
- PMC8931612
- OpenAlex
- W1531838059
- Cited by
- 93
- References
- 131
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 8 · 2023: 14 · 2022: 9 · 2021: 7 · 2020: 10 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 7 · 2015: 4 · 2012: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- anxiety disorders, alcoholism, comorbidities, pharmacotherapy, antidepressants, anxiolytics, benzodiazepines, treatment response, symptom severity, predictors of treatment response, tolerability, adverse effects, relapse, relapse prevention
- MeSH terms
- Phobia, Social, Anxiety, Anxiety Disorders, Buspirone, Desipramine, Humans, Stress Disorders, Post-Traumatic, Comorbidity, Randomized Controlled Trials as Topic, Selective Serotonin Reuptake Inhibitors, Paroxetine, Publication Bias, Alcohol-Related Disorders, Sertraline
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