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Pharmacological interventions for prevention or treatment of postoperative pain in people undergoing laparoscopic cholecystectomy
Open accessAbstract
Background While laparoscopic cholecystectomy is generally considered less painful than open surgery, pain is one of the important reasons for delayed discharge after day-surgery and overnight stay following laparoscopic cholecystectomy. The safety and effectiveness of different pharmacological interventions such as non-steroidal anti-inflammatory drugs, opioids, and anticonvulsant analgesics in people undergoing laparoscopic cholecystectomy is unknown. Objectives To assess the benefits and harms of different analgesics in people undergoing laparoscopic cholecystectomy. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, Science Citation Index Expanded, and the World Health Organization International Clinical Trials Registry Platform portal (WHO ICTRP) to March 2013 to identify randomised clinical trials of relevance to this review. Selection criteria We considered only randomised clinical trials (irrespective of language, blinding, or publication status) comparing different pharmacological interventions with no intervention or inactive controls for outcomes related to benefit in this review. We considered comparative non-randomised studies with regards to treatment-related harms. We also considered trials that compared one class of drug with another class of drug for this review. Data collection and analysis Two review authors collected the data independently. We analysed the data with both fixed-effect and random-effects…
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Inadequately controlled acute pain and excessive opioid use delay recovery and hospital discharge after many surgeries.
“Inadequately controlled acute pain and excessive opioid use delay recovery and hospital discharge after many surgeries.53–56”
From Chronic postsurgical pain: From risk factor identification to multidisciplinary management at the Toronto General Hospital Transitional Pain Service (2019) · cites this paper as [54]
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Metadata
- Authors
- Gurusamy, K. S., Vaughan, J., Toon, C. D., & Davidson, B. R.
- Affiliations
- The Royal Free Hospital (GB)
- West Sussex County Council; Public Health; 1st Floor, The Grange Tower Street Chichester West Sussex UK PO19 1QT
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2014-03-28
- Volume
- 2014
- Issue
- 3
- Pages
- CD008261-CD008261
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- PMC
- PMC11086628
- OpenAlex
- W2161418736
- Cited by
- 51
- References
- 136
- Citations by year
- 2024: 1 · 2023: 5 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 8 · 2018: 5 · 2017: 10 · 2016: 2 · 2015: 11 · 2014: 3
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (10/4001/11)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Surgery › Nausea and vomiting management
- Keywords
- laparoscopic cholecystectomy, postoperative pain, analgesia, nonsteroidal anti-inflammatory drugs, opioids, outpatient surgery, length of hospital stay, return to work, adverse drug reactions, postoperative nausea and vomiting, postoperative delirium, postoperative complications, analgesic safety, postoperative mortality, postoperative morbidity
- MeSH terms
- Ambulatory Surgical Procedures, Analgesics, Analgesics, Opioid, Anti-Inflammatory Agents, Non-Steroidal, Anticonvulsants, Humans, Length of Stay, Pain Measurement, Postoperative Pain, Time Factors, Randomized Controlled Trials as Topic, Cholecystectomy, Laparoscopic, Elective Surgical Procedures
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