Xpert MTB/RIF test for detection of pulmonary tuberculosis and rifampicin resistance
Abstract
This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: Primary objectives Review question A: To obtain summary estimates of the diagnostic accuracy of Xpert MTB/RIF for the diagnosis of pulmonary TB, using solid or liquid culture as a reference standard. Purpose of index test: A.1 Xpert MTB/RIF as a replacement test for smear microscopy. A.2. Xpert MTB/RIF as an add‐on test after smear microscopy. Review question B: To obtain summary estimates of the diagnostic accuracy of Xpert MTB/RIF for detection of rifampicin resistance, using solid or liquid culture as a reference standard (WHO 2008). Purpose of index test: B.1 Xpert MTB/RIF as a replacement test for WHO‐approved tests for detection of rifampicin resistance.
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For detection of rifampicin resistance in extrapulmonary specimens, the sensitivity and specificity of Xpert Ultra and Xpert MTB/RIF were comparable to estimates in pulmonary specimens.
“For detection of rifampicin resistance in extrapulmonary specimens, we found the sensitivity of Xpert Ultra (100%) and Xpert MTB/RIF (96.7%) and the specificity of Xpert Ultra (100%) and Xpert MTB/RIF (99.1%), to be comparable to estimates in pulmonary specimens: sensitivity (96%) and specificity (98%) (Horne 2019).”
From Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults (2021) · cites this paper as Horne 2019
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References 58 · Cited by 20
- Authors
- Sohn, H., Pai, M., Dendukuri, N., Kloda, L. A., Boehme, C. C., & Steingart, K. R.
- Affiliations
- McGill University (CA)
- FIND (CH)
- University of Washington (US)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- John Wiley & Sons, Ltd
- Published
- 2012-01-18
- ISSN
- 1361-6137 (ISSN-L)
- OpenAlex
- W2062775631
- Cited by
- 20
- References
- 58
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 2 · 2014: 2 · 2013: 2
- Type
- reference entry
- Language
- en
- Open access
- closed
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Keywords
- Xpert MTB/RIF, pulmonary tuberculosis, rifampicin resistance, diagnostic accuracy, smear microscopy, liquid culture, solid culture, tuberculosis diagnosis, molecular diagnosis
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