Non-pharmacological interventions for depression in adults and children with traumatic brain injury
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Background Following traumatic brain injury (TBI) there is an increased prevalence of depression compared to the general population. It is unknown whether non-pharmacological interventions for depression are effective for people with TBI. Objectives To investigate the effectiveness of non-pharmacological interventions for depression in adults and children with TBI at reducing the diagnosis and severity of symptoms of depression. Search methods We ran the most recent search on 11 February 2015. We searched the Cochrane Injuries Group Specialised Register, The Cochrane Library, MEDLINE (OvidSP), Embase (OvidSP), three other databases and clinical trials registers. Relevant conference proceedings and journals were handsearched, as were the reference lists of identified studies. Selection criteria Randomised controlled trials (RCTs) of non-pharmacological interventions for depression in adults and children who had a TBI. Data collection and analysis Two authors independently selected trials from the search results, then assessed risk of bias and extracted data from the included trials. The authors contacted trial investigators to obtain missing information. We rated the overall quality of the evidence of the primary outcomes using the GRADE approach. Main results Six studies met the inclusion criteria, with a total of 334 adult participants. We identified no studies that included children as participants. All studies were affected by high risk of bias due to a lack of blinding of…
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Evidence for the efficacy of rehabilitation programs targeting cognition and mood separately remains mixed.
“However, evidence for the efficacy of rehabilitation programs targeting cognition and mood separately remains mixed (Gertler et al., 2015;Lincoln & Flannaghan, 2003;Ponsford et al., 2016;Rogers et al., 2018).”
From A single-case experimental evaluation of a new group-based intervention to enhance adjustment to life with acquired brain injury: VaLiANT (valued living after neurological trauma) (2022) · cites this paper as Gertler et al., 2015
Cognitive Behavioural Therapy for depression and/or anxiety has been shown to improve mood in some studies but not others, with some indication that trial design and dose of therapy may impact outcomes.
“Similarly, Cognitive Behavioural Therapy (CBT) for depression and/or anxiety has been shown to improve mood in some studies but not others, with some indication that trial design and dose of therapy may impact outcomes (Gertler et al., 2015;Ponsford et al., 2016;Wang et al., 2018).”
From A single-case experimental evaluation of a new group-based intervention to enhance adjustment to life with acquired brain injury: VaLiANT (valued living after neurological trauma) (2022) · cites this paper as Gertler et al., 2015
CBT for depression and/or anxiety has been shown to improve mood in some studies but not others, with some indication that trial design and dose of therapy may impact outcomes.
“Cognitive Behavioural Therapy (CBT) for depression and/or anxiety has been shown to improve mood in some studies but not others, with some indication that trial design and dose of therapy may impact outcomes (Gertler et al., 2015;Ponsford et al., 2016;Wang et al., 2018).”
From A single-case experimental evaluation of a new group-based intervention to enhance adjustment to life with acquired brain injury: VaLiANT (valued living after neurological trauma) (2022) · cites this paper as Gertler et al., 2015
Studies investigating interventions for ABI-related anxiety and depressive complaints are scarce.
“Studies investigating interventions for ABI-related anxiety and depressive complaints are scarce (Gertler et al., 2015; Stalder-Lüthy et al., 2013) and there are therefore limited evidence-based treatment options (Beedham et al., 2020; Knapp et al., 2017).”
From Acceptance and commitment therapy for individuals with depressive and anxiety symptoms following acquired brain injury: A non-concurrent multiple baseline design across four cases. (2023) · cites this paper as Gertler et al., 2015
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References 85 · Cited by 69
- Authors
- Gertler, P., Tate, R. L., & Cameron, I. D.
- Affiliations
- The University of Sydney (AU)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2015-12-14
- Volume
- 2015
- Issue
- 12
- Pages
- CD009871-CD009871
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- PMC
- PMC8761477
- OpenAlex
- W1897570789
- Cited by
- 69
- References
- 85
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 8 · 2021: 6 · 2020: 12 · 2019: 11 · 2018: 8 · 2017: 4 · 2016: 3 · 2013: 1
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- traumatic brain injury, depression, non-pharmacological treatment, cognitive behavioral therapy, mindfulness-based cognitive therapy, repetitive transcranial magnetic stimulation, tricyclic antidepressants, supportive therapy, depression severity, risk of bias, treatment effectiveness, depression relapse prevention
- MeSH terms
- Suicide Prevention, Adult, Antidepressive Agents, Brain Injuries, Child, Depression, Humans, Exercise, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Transcranial Magnetic Stimulation, Mindfulness
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