Adjuvant therapy with antidepressants for the management of inflammatory bowel disease
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The optimal dose and duration of SSRIs for depression and anxiety in IBD remain uncertain.
“the optimal dose and duration of SSRIs for depression and anxiety in IBD remain uncertain (79)”
From The 2023 Impact of Inflammatory Bowel Disease in Canada: Mental Health and Inflammatory Bowel Disease (2023) · cites this paper as [79]
The Description of the intervention says antidepressant dosage regimens vary and treatment duration ranges widely. The Authors’ conclusions say efficacy in IBD remains uncertain, but the review does not specifically assess the optimal SSRI dose or duration for depression and anxiety in IBD. Page numbers were not available in our copy. (LLM, conf=0.78)
Experimental — accuracy not yet measuredThere remains little data on efficacy of antidepressant medications directly in IBD.
“there remains little data on efficacy directly in IBD (56,79).”
From The 2023 Impact of Inflammatory Bowel Disease in Canada: Mental Health and Inflammatory Bowel Disease (2023) · cites this paper as [79]
In diseases such as epilepsy, inflammatory bowel disease, traumatic brain injury, asthma and chronic obstructive pulmonary disease, few or no RCTs of antidepressant treatment for comorbid MDD have been conducted.
“In other diseases – such as epilepsy, inflammatory bowel disease, traumatic brain injury, asthma and chronic obstructive pulmonary disease – few or no RCTs of antidepressant treatment for comorbid MDD have been conducted295-301”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [297]
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References 62 · Cited by 59
Research works printed but not linked: 19
- Canadian surveys. Inflammatory Bowel Diseases 2006;12(8): 697-707.
- Gartlehner G, Hansen RA, Morgan LC, Thaler K, Lux LJ, Van Noord M, et al. Second-generation antidepressants in the pharmacologic treatment of adult depression: An update of the 2007 comparative effectiveness review. Rockville, MD: Agency for Healthcare Research and Quality, 2011.
- Gordon A, Mikocka-Walus A, Grzeskowiak LE, Jayasekara RS. Antidepressants for depression during pregnancy. Cochrane Database of Systematic Reviews 2013, Issue 8. DOI: 10.1002/14651858.CD010710 Gracie 2017 · DOI
- Gracie DJ, Irvine AJ, Sood R, Mikocka-Walus A, Hamlin PJ, Ford AC. Effect of psychological therapy on disease activity, psychological comorbidity, and quality of life in inflammatory bowel disease: a systematic review and meta- analysis. Lancet Gastroenterology and Hepatology 2017;2(3): 189-199.
- Guemei AA, El Din NM, Baraka AM, El Said Darwish I. Do desipramine [10,11-dihydro-5-[3-(methylamino) propyl]- 5H-dibenz[b,f ]azepine monohydrochloride] and fluoxetine [N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]- propan-1-amine] ameliorate the extent of colonic damage induced by acetic acid in rats?. Journal of Pharmacology and Experimental Therapeutics 2008;327(3):846-50.
- Haapamaki J, Tanskanen A, Roine RP, Blom M, Turunen U, Mantyla J, et al. Medication use among inflammatory bowel disease patients: excessive consumption of antidepressants and analgesics. Scandinavian Journal of Gastroenterology 2013;48(1):42-50.
- Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327 (7414):557-60.
- Higgins JPT, Altman DG, Sterne JAC (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011).
- Knowles SR, Monshat K, Castle DJ. The efficacy and methodological challenges of psychotherapy for adults with inflammatory bowel disease: a review. Inflammatory Bowel Diseases 2013;19(12):2704-15.
- Krommydas G, Gourgoulianis KI, Karamitsos K, Krapis K, Kotrotsiou E, Molyvdas PA. Therapeutic value of antidepressants in asthma. Medical Hypotheses 2005;64(5): 938-40.
- Loftus 2004 Loftus EV. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 2004;126(6):1504-17.
- Macer B, Prady S, Mikocka-Walus A. Antidepressants in inflammatory bowel disease: A systematic review. Inflammatory Bowel Diseases 2017;23(4):534-50.
- Maes M. The immunoregulatory effects of antidepressants. Human Psychopharmacology 2001;16(1):95-103.
- Maunder RG, Levenstein S. The role of stress in the development and clinical course of inflammatory bowel disease: epidemiological evidence. Current Molecular Medicine 2008;8(4):247-52.
- Mikocka-Walus 2006 Mikocka-Walus AA, Turnbull DA, Moulding NT, Wilson IG, Andrews JM, Holtmann GJ. Antidepressants and inflammatory bowel disease: a systematic review. Clinical Practice and Epidemiology in Mental Health 2006;2:24.
- Mikocka-Walus 2007 Mikocka-Walus AA, Turnbull DA, Moulding NT, Wilson IG, Andrews JM, Holtmann GJ. "It doesn't do any harm, but patients feel better": a qualitative exploratory study on gastroenterologists' perspectives on the role of antidepressants in inflammatory bowel disease. BMC Gastroenterology 2007;7:38.
- Mikocka-Walus 2009 Mikocka-Walus A, Clarke D, Gibson P. Can antidepressants influence the course of inflammatory bowel disease (IBD)? The current state of research. European Gastroenterology and Hepatology Review 2009;5(1):48-53.
- Mikocka-Walus 2016a Mikocka-Walus A, Knowles SR, Keefer L, Graff L. Controversies revisited: A systematic review of the comorbidity of depression and anxiety with inflammatory bowel diseases. Inflammatory Bowel Diseases 2016;22(3): 752-62.
- Antonina Mikocka-Walus, Andrea Gordon, Adrian Esterman and Jane Andrews are co-authors of a trial that was included in this systematic review (Mikocka-Walus 2016c). Data extraction and risk of bias assessment for this study were carried out by Justyna Pollok, Stephanie Prady and Simon Knowles.
- Authors
- Mikocka-Walus, A., Prady, S. L., Pollok, J., Esterman, A. J., Gordon, A. L., Knowles, S., & Andrews, J. M.
- Affiliations
- Deakin University Geelong; School of Psychology; 221 Burwood Highway Burwood, VIC Victoria Australia 3025
- University of York (GB)
- The University of Adelaide (AU)
- University of South Australia (AU)
- Swinburne University of Technology (AU)
- Royal Adelaide Hospital (AU)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2019-04-12
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- OpenAlex
- W3082313817
- Cited by
- 59
- References
- 62
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 12 · 2022: 15 · 2021: 9 · 2020: 3 · 2019: 1
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- UniSA Research Outputs Repository (University of South Australia) (acceptedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- antidepressants, inflammatory bowel disease, adjuvant therapy, depression, anxiety, irritable bowel syndrome, Crohn's disease, ulcerative colitis
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