Phototherapy for atopic eczema
Open accessAbstract
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of phototherapy regimen (e.g. NB-UVB, BB-UVB, PUVA, UVA1) for people with atopic eczema.
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This pattern is consistent with suppression of both Th1 and Th2 responses after phototherapy in atopic dermatitis, likely due to induction of T-cell apoptosis.
“This pattern is consistent with the suppression of both T helper 1 and T helper 2 responses after phototherapy in atopic dermatitis, likely due to the induction of T-cell apoptosis (Franken et al, 2015;Musters et al, 2021;Ozawa et al, 1999).”
From Effect of Repeated Low-Dose UVR Exposure on Skin Inflammation Threshold, Skin Biomarkers, and Vitamin D in Healthy Adults (2025) · cites this paper as Musters et al, 2021
The Abstract (page unavailable) identifies this as a protocol to assess phototherapy for atopic eczema. Our copy does not address suppression of Th1 or Th2 responses or T-cell apoptosis; searches for those terms and the proposed mechanism found no relevant passage. (LLM, conf=0.76)
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Cites
RoB 2: a revised tool for assessing risk of bias in randomised trials
Sterne, J. A. C., Savović, J., Page, M. J., Elbers, R. G., Blencowe, N. S., Boutron, I., Cates, C. J., Cheng, H.-Y., Corbett, M. S., Eldridge, S. M., et al. (2019) · BMJ · doi:10.1136/bmj.l4898 · Cited by 33,583 · see citing works
Weidinger, S., & Novak, N. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00149-x · Cited by 1,908 · see citing works
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The role of lebrikizumab in the treatment of atopic dermatitis in the adult population
Prajapati, S., Fardos, M., Desai, A. D., & Feldman, S. R. (2023) · Immunotherapy · doi:10.2217/imt-2023-0066 · Cited by 4 · see citing works
de Boer, F., Kezic, S., van der Lelie, G., Motazedi, E., Rustemeyer, T., van Dijk, A., Almasian, M., Jakasa, I., & van der Molen, H. F. (2025) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.01.024 · Cited by 4 · see citing works
- Authors
- Musters, A. H., Mashayekhi, S., Flohr, C., Drucker, A. M., Gerbens, L., Ferguson, J., Ibbotson, S., Dawe, R. S., Garritsen, F., Brouwer, M., Limpens, J., Lax, S. J., Harvey, J., & Spuls, P. I.
- Affiliations
- Amsterdam University Medical Centers (NL)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- University of Toronto (CA)
- University of Dundee (GB)
- Haga Hospital (NL)
- Antonius Ziekenhuis (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- University of Nottingham (GB)
- ORCID
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2021-02-13
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- OpenAlex
- W4237236089
- Cited by
- 31
- References
- 2
- Citations by year
- 2025: 6 · 2024: 9 · 2023: 12 · 2022: 3 · 2021: 1
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Update notices
- new_version (2021-10-28)
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- other-oa
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- phototherapy, atopic dermatitis, narrowband UVB, broadband UVB, PUVA, UVA1
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