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Cited by 244Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular DiseasesImmune Response and Inflammation

Liver X receptors link lipid metabolism and inflammation

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Schulman, Ira G.·2017·FEBS Letters
DOI 10.1002/1873-3468.12702PMC PMC5638683
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Abstract

The response of immune cells to pathogens is often associated with changes in the flux through basic metabolic pathways. Indeed, in many cases changes in metabolism appear to be necessary for a robust immune response. The Liver X receptors (LXR s) are members of the nuclear hormone receptor superfamily that regulate gene networks controlling cholesterol and lipid metabolism. In immune cells, particularly in macrophages, LXR s also inhibit proinflammatory gene expression. This Review will highlight recent studies that connect LXR‐dependent control of lipid metabolism to regulation of the immune response.

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  • Abnormal lipid metabolism is directly linked to inflammation.

    “Additionally, abnormal lipid metabolism is directly linked to inflammation [204], which is a component of pathology in both typical and atypical cases of RTT [205].”

    From Rett syndrome: a neurological disorder with metabolic components (2018) · cites this paper as [204]

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Authors
Schulman, I. G.
Affiliations
University of Virginia (US)
Corresponding author
Schulman, Ira G.
ORCID
Schulman, Ira G.
Venue
FEBS Letters
Publisher
Wiley
Published
2017-06-13
Volume
591
Issue
19
Pages
2978-2991
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
DOI
10.1002/1873-3468.12702
PMC
PMC5638683
OpenAlex
W2618666860
Cited by
244
References
115
Citations by year
2026: 22 · 2025: 35 · 2024: 33 · 2023: 28 · 2022: 21 · 2021: 42 · 2020: 29 · 2019: 18 · 2018: 10 · 2017: 6
FWCI
3.65
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • American Heart Association (15GRNT25560038)
  • National Institutes of Health (1R56HL131779‐01)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
liver X receptor, lipid metabolism, inflammation, immune response, macrophages, cholesterol metabolism, nuclear receptors, pro-inflammatory gene expression, metabolic reprogramming
MeSH terms
Liver X Receptors, Animals, DNA, Humans, Inflammation, Transcription, Genetic, Lipid Metabolism, Gene Regulatory Networks

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