The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Structural and functional diversity calls for a new classification of ABC transporters
Open accessAbstract
Members of the ATP‐binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP‐binding cassette in the nucleotide‐binding domains (NBDs) is highly conserved, their transmembrane domains (TMDs) forming the translocation pathway exhibit distinct folds and topologies, suggesting that during evolution the ancient motor domains were combined with different transmembrane mechanical systems to orchestrate a variety of cellular processes. In recent years, it has become increasingly evident that the distinct TMD folds are best suited to categorize the multitude of ABC transporters. We therefore propose a new ABC transporter classification that is based on structural homology in the TMDs.
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Cites
The Human ATP-Binding Cassette (ABC) Transporter Superfamily
Dean, M., Rzhetsky, A., & Allikmets, R. (2001) · Genome Research · doi:10.1101/gr.184901 · Cited by 1,748
Self-citationStructure of a bacterial multidrug ABC transporter
Dawson, R. J. P., & Locher, K. P. (2006) · Nature · doi:10.1038/nature05155 · Cited by 1,279
The E. coli BtuCD Structure: A Framework for ABC Transporter Architecture and Mechanism
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Mutation of the Stargardt Disease Gene ( ABCR ) in Age-Related Macular Degeneration
Allikmets, R., Shroyer, N. F., Singh, N., Seddon, J. M., Lewis, R. A., Bernstein, P. S., Peiffer, A., Zabriskie, N. A., Li, Y., Hutchinson, A., et al. (1997) · Science · doi:10.1126/science.277.5333.1805 · Cited by 880
Self-citationPDR-type ABC transporter mediates cellular uptake of the phytohormone abscisic acid
Kang, J., Hwang, J.-U., Lee, M., Kim, Y.-Y., Assmann, S. M., Martinoia, E., & Lee, Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909222107 · Cited by 764
Self-citationA family of related ATP-binding subunits coupled to many distinct biological processes in bacteria
Higgins, C. F., Hiles, I. D., Salmond, G. P. C., Gill, D. R., Downie, J. A., Evans, I. J., Holland, I. B., Gray, L., Buckel, S. D., Bell, A. W., et al. (1986) · Nature · doi:10.1038/323448a0 · Cited by 755
Self-citationAn inventory of the human ABC proteins
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Self-citationStructural and Mechanistic Principles of ABC Transporters
Thomas, C., & Tampé, R. (2020) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-011520-105201 · Cited by 563
Self-citationMolecular Structure of the Human CFTR Ion Channel
Liu, F., Zhang, Z., Csanády, L., Gadsby, D. C., & Chen, J. (2017) · Cell · doi:10.1016/j.cell.2017.02.024 · Cited by 523
Crystal structure of a catalytic intermediate of the maltose transporter
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Ins and outs of AlphaFold2 transmembrane protein structure predictions
Hegedűs, T., Geisler, M., Lukács, G. L., & Farkas, B. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04112-1 · Cited by 127
Structure and function of ABCA4 and its role in the visual cycle and Stargardt macular degeneration
Molday, R. S., Garces, F. A., Scortecci, J. F., & Molday, L. L. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.101036 · Cited by 107
Structure of an endogenous mycobacterial MCE lipid transporter
Chen, J., Fruhauf, A., Fan, C., Ponce, J., Ueberheide, B., Bhabha, G., & Ekiert, D. C. (2023) · Nature · doi:10.1038/s41586-023-06366-0 · Cited by 69
Self-citationChaves, J. C. S., Dando, S. J., White, A. R., & Oikari, L. E. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166967 · Cited by 62
Metadata
- Authors
- Thomas, C., Aller, S. G., Beis, K., Carpenter, E. P., Chang, G., Chen, L., Dassa, E., Dean, M., Duong Van Hoa, F., Ekiert, D., Ford, R., Gaudet, R., Gong, X., Holland, I. B., Huang, Y., Kahne, D. K., Kato, H., Koronakis, V., Koth, C. M., Lee, Y., Lewinson, O., Lill, R., Martinoia, E., Murakami, S., Pinkett, H. W., Poolman, B., Rosenbaum, D., Sarkadi, B., Schmitt, L., Schneider, E., Shi, Y., Shyng, S., Slotboom, D. J., Tajkhorshid, E., Tieleman, D. P., Ueda, K., Váradi, A., Wen, P., Yan, N., Zhang, P., Zheng, H., Zimmer, J., & Tampé, R.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2020-10-26
- Volume
- 594
- Issue
- 23
- Pages
- 3767-3775
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W3088763537
- Cited by
- 281
- References
- 65
- FWCI
- 12.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Thomas, C., Aller, S. G., Beis, K., Carpenter, E. P., Chang, G., Chen, L., Dassa, E., Dean, M., Duong Van Hoa, F., Ekiert, D., Ford, R., Gaudet, R., Gong, X., Holland, I. B., Huang, Y., Kahne, D. K., Kato, H., Koronakis, V., Koth, C. M., . . . Tampé, R. (2020). Structural and functional diversity calls for a new classification of ABC transporters. FEBS Letters. https://doi.org/10.1002/1873-3468.13935
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
