The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Growing and Analyzing Static Biofilms
Open accessAbstract
Many bacteria can exist as surface‐attached aggregations known as biofilms. Presented in this unit are several approaches for the study of these communities. The focus here is on static biofilm systems, which are particularly useful for examination of the early stages of biofilm formation, including initial adherence to the surface and microcolony formation. Furthermore, most of the techniques presented are easily adapted to the study of biofilms under a variety of conditions and are suitable for either small‐ or relatively large‐scale studies. Unlike assays involving continuous‐flow systems, the static biofilm assays described here require very little specialized equipment and are relatively simple to execute. In addition, these static biofilm systems allow analysis of biofilm formation with a variety of readouts, including microscopy of live cells, macroscopic visualization of stained bacteria, and viability counts. Used individually or in combination, these assays provide useful means for the study of biofilms.
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“LPS, a gram-negative bacterial cell wall component and an agonist to toll-like receptor 4, was used to trigger THP-1 cells to release inflammatory cytokines [54].”
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Anderl, J. N., Franklin, M. J., & Stewart, P. S. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.7.1818-1824.2000 · Cited by 958
Cited by
Colvin, K. M., Gordon, V. D., Murakami, K., Borlee, B. R., Wozniak, D. J., Wong, G. C. L., & Parsek, M. R. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001264 · Cited by 577
Applying insights from biofilm biology to drug development — can a new approach be developed?
Bjarnsholt, T., Ciofu, O., Molin, S., Givskov, M., & Høiby, N. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4000 · Cited by 516
Maisonneuve, E., Castro-Camargo, M., & Gerdes, K. (2013) · Cell · doi:10.1016/j.cell.2013.07.048 · Cited by 438
RetractedNguyen, N.-Y. T., Grelling, N., Wetteland, C. L., Rosario, R., & Liu, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-34567-5 · Cited by 357
Wilksch, J. J., Yang, J., Clements, A., Gabbe, J. L., Short, K. R., Cao, H., Cavaliere, R., James, C. E., Whitchurch, C. B., Schembri, M. A., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002204 · Cited by 302
Metadata
- Authors
- Merritt, J. H., Kadouri, D. E., & O'Toole, G. A.
- Venue
- Current Protocols in Microbiology
- Publisher
- Wiley
- Published
- 2005-07-15
- Volume
- 00
- Issue
- 1
- Pages
- Unit 1B.1-Unit 1B.1
- ISSN
- 1934-8525 (ISSN-L)
- 1934-8533
- OpenAlex
- W2138779519
- Cited by
- 1,086
- References
- 1
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Merritt, J. H., Kadouri, D. E., & O'Toole, G. A. (2006). Growing and Analyzing Static Biofilms. Current Protocols in Microbiology. https://doi.org/10.1002/9780471729259.mc01b01s00
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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