Host Response of Implanted Biomaterials
Abstract
Biomaterials interact with the living system. Depending on the location and the nature of the biomaterial, the response of the body to the biomaterial may vary. Biomaterial implantation within the host causes an injury. There are two broad phenomenon taking place after every biomaterial implant: tissue response and biomaterial response. The beginning of tissue response is marked by the interaction of blood proteins with the biomaterial. Unlike living tissue, implanted biomaterials are not “rejected,” but they still elicit an immune response called foreign body response. Biomaterials at times may give out leachates, which cause allergy in the host system and/or other immune responses. The dynamic interplay between the host cells/tissue and the biomaterial, shall decide the level of biocompatibility. Stability and sustained functionality focus on the integrity of the material and the host tissue throughout the implant lifetime; these terms bring in the facet of material quality into the picture.
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The degree of encapsulation and composition of the FBC is a major determinant of whether the appropriate response is achieved.
“The degree of encapsulation and composition of the FBC is a major determinant of whether the appropriate response is achieved.[ 48 ]”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [48]
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Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials
Sheikh, Z., Brooks, P., Barzilay, O., Fine, N., & Glogauer, M. (2015) · Materials · doi:10.3390/ma8095269 · Cited by 701 · see citing works
ten Brink, T., Damanik, F., Rotmans, J. I., & Moroni, L. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202301939 · Cited by 71 · see citing works
- Authors
- Rajesh, P. S. M., Verma, S., & Verma, V.
- Affiliations
- Indian Institute of Technology Kanpur (IN)
- ORCID
- Verma, Vivek
- Venue
- Biosurfaces
- Publisher
- Wiley
- Published
- 2014-12-12
- Pages
- 106-125
- OpenAlex
- W1552955016
- Cited by
- 11
- References
- 0
- Citations by year
- 2024: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2017: 1 · 2015: 3
- Type
- other
- Language
- en
- Open access
- closed
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- biomaterial implantation, host response, tissue reaction, foreign body reaction, biocompatibility, allergic reactions, immune response, implant survival
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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