Cited by 36Protein Structure and DynamicsRedox biology and oxidative stressChemical Synthesis and Analysis

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Role of Disulfide Bonds in Peptide and Protein Conformation

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Khoo, Keith K., Norton, Raymond S.·2011·Amino Acids, Peptides and Proteins in Organic Chemistry

Abstract

This chapter contains sections titled: Introduction Probing the Role of Disulfide Bonds Contribution of Disulfide Bonds to Protein Stability Role of Disulfide Bonds in Protein Folding Role of Individual Disulfide Bonds in Protein Structure Disulfide Bonds in Protein Dynamics Disulfide Bonding Patterns and Protein Topology Applications Conclusions References

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  • Although sulfhydryl groups are less abundant, disulfide bonds they form are strong and high-energy covalent linkages that play a critical role in stabilizing and reinforcing the protein network, which can make disulfide bond a major force in gel formation.

    “Although sulfhydryl groups are less abundant, the disulfide bonds they form are strong and high‐energy covalent linkages that play a critical role in stabilizing and reinforcing the protein network (Khoo and Norton 2011; M. Chen, Wang, et al. 2023), which can make disulfide bond a major force in gel formation.”

    From Designing Protein Gels for Nutrient Delivery: From Formulation to Digestion (2026) · cites this paper as Khoo and Norton 2011

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Metadata

Authors
Khoo, K. K., & Norton, R. S.
Affiliations
  • The University of Melbourne (AU)
  • Monash University (AU)
Venue
Amino Acids, Peptides and Proteins in Organic Chemistry
Publisher
Wiley
Published
2011-10-19
Pages
395-417
OpenAlex
W1528805424
Cited by
36
References
123
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 1 · 2014: 2 · 2013: 1
Type
other
Language
en
Open access
Locations
Monash University Research Portal (Monash University) (submittedVersion, other-oa)
Funders
  • Medical Research Council
  • National Health and Medical Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
Keywords
disulfide bonds, protein conformation, peptide conformation, protein stability, protein folding, protein dynamics, protein topology

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