Autoimmune encephalomyelitis in NOD mice is not initially a progressive multiple sclerosis model

Baker, David; Nutma, Erik; O'Shea, Helen; Cooke, Anne; Orian, Jacqueline M.; Amor, Sandra

doi:10.1002/acn3.792

Autoimmune encephalomyelitis in NOD mice is not initially a progressive multiple sclerosis model

Objective: Despite progress in treating relapsing multiple sclerosis (MS), effective inhibition of nonrelapsing progressive MS is an urgent, unmet, clinical need. Animal models of MS, such as experimental autoimmune encephalomyelitis (EAE), provide valuable tools to examine the mechanisms contrib…