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Cited by 983

The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.

2020 American College of Rheumatology Guideline for the Management of Gout

Open access
FitzGerald, John D., Dalbeth, Nicola, Mikuls, Ted, Brignardello‐Petersen, Romina, Guyatt, Gordon, Abeles, Aryeh M., Gelber, Allan C., Harrold, Leslie R., Khanna, Dinesh, King, Charles, Levy, Gerald, Libbey, Caryn, Mount, David, Pillinger, Michael H., Rosenthal, Ann, Singh, Jasvinder A., Sims, James Edward, Smith, Benjamin J., Wenger, Neil S., Bae, Sangmee Sharon, Danve, Abhijeet, Khanna, Puja P., Kim, Seoyoung C., Lenert, Aleksander, Poon, Samuel, Qasim, Anila, Sehra, Shiv T., Sharma, Tarun Sudhir Kumar, Toprover, Michael, Turgunbaev, Marat, Zeng, Linan, Zhang, Mary Ann, Turner, Amy S., Neogi, Tuhina·2020·Arthritis Care & Research
DOI 10.1002/acr.24180
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Abstract

Objective: To provide guidance for the management of gout, including indications for and optimal use of urate‐lowering therapy (ULT), treatment of gout flares, and lifestyle and other medication recommendations. Methods: Fifty‐seven population, intervention, comparator, and outcomes questions were developed, followed by a systematic literature review, including network meta‐analyses with ratings of the available evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, and patient input. A group consensus process was used to compose the final recommendations and grade their strength as strong or conditional. Results: Forty‐two recommendations (including 16 strong recommendations) were generated. Strong recommendations included initiation of ULT for all patients with tophaceous gout, radiographic damage due to gout, or frequent gout flares; allopurinol as the preferred first‐line ULT, including for those with moderate‐to‐severe chronic kidney disease (CKD; stage >3); using a low starting dose of allopurinol (≤100 mg/day, and lower in CKD) or febuxostat (<40 mg/day); and a treat‐to‐target management strategy with ULT dose titration guided by serial serum urate (SU) measurements, with an SU target of <6 mg/dl. When initiating ULT, concomitant antiinflammatory prophylaxis therapy for a duration of at least 3–6 months was strongly recommended. For management of gout flares, colchicine, nonsteroidal antiinflammatory drugs, or glucocorticoids (oral, intraarticular, or intramuscular) were strongly recommended. Conclusion: Using GRADE methodology and informed by a consensus process based on evidence from the current literature and patient preferences, this guideline provides direction for clinicians and patients making decisions on the management of gout.

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Metadata

Authors
FitzGerald, J. D., Dalbeth, N., Mikuls, T., Brignardello‐Petersen, R., Guyatt, G., Abeles, A. M., Gelber, A. C., Harrold, L. R., Khanna, D., King, C., Levy, G., Libbey, C., Mount, D., Pillinger, M. H., Rosenthal, A., Singh, J. A., Sims, J. E., Smith, B. J., Wenger, N. S., Bae, S. S., Danve, A., Khanna, P. P., Kim, S. C., Lenert, A., Poon, S., Qasim, A., Sehra, S. T., Sharma, T. S. K., Toprover, M., Turgunbaev, M., Zeng, L., Zhang, M. A., Turner, A. S., & Neogi, T.
Venue
Arthritis Care & Research
Publisher
Wiley
Published
2020-05-11
Volume
72
Issue
6
Pages
744-760
ISSN
  • 0893-7524 (ISSN-L)
  • 2151-464X
  • 2151-4658
DOI
10.1002/acr.24180
OpenAlex
W4229537562
Cited by
983
References
103
FWCI
61.74
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: 2020 American College of Rheumatology Guideline for the Management of Gout. https://app.cochat.ai/papers/10.1002/acr.24180
The paper
FitzGerald, J. D., Dalbeth, N., Mikuls, T., Brignardello‐Petersen, R., Guyatt, G., Abeles, A. M., Gelber, A. C., Harrold, L. R., Khanna, D., King, C., Levy, G., Libbey, C., Mount, D., Pillinger, M. H., Rosenthal, A., Singh, J. A., Sims, J. E., Smith, B. J., Wenger, N. S., . . . Neogi, T. (2020). 2020 American College of Rheumatology Guideline for the Management of Gout. Arthritis Care & Research. https://doi.org/10.1002/acr.24180

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.