Polymer‐Based Nitric Oxide Therapies: Recent Insights for Biomedical Applications
Open accessAbstract
Since the discovery of nitric oxide (NO) in the 1980s, this cellular messenger has been shown to participate in diverse biological processes such as cardiovascular homeostasis, immune response, wound healing, bone metabolism, and neurotransmission. Its beneficial effects have prompted increased research in the past two decades, with a focus on the development of materials that can locally release NO. However, significant limitations arise when applying these materials to biomedical applications. This Feature Article focuses on the development of NO‐releasing and NO‐generating polymeric materials (2006–2011) with emphasis on recent in vivo applications. Results are compared and discussed in terms of NO dose, release kinetics, and biological effects, in order to provide a foundation to design and evaluate new NO therapies.
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The human body synthesizes bio-regulatory NO from L-arginine via three NOS isoforms: eNOS, nNOS, and iNOS.
“The human body synthesizes a large quantity of bio-regulatory NO from the substrate L-arginine via three distinct isoforms of nitric oxide synthase (NOS), including endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS).118–120”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [120]
RSNOs are an endogenous class of NO donors and natural transporters of NO in tissues and blood.
“S-Nitrosothiols (RSNO) represent an endogenous class of NO donors and natural transporters of NO within tissues and blood.120,158”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [120]
iNOS is synthesized in the early phase of wound healing by inflammatory cells such as macrophages, monocytes, and other immune lineage cells.
“The iNOS is synthesized in the early phase of wound healing by inflammatory cells, such as macrophages, monocytes, and other immune lineage cells.119,120,292”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [120]
NO has antimicrobial activity against a growing list of microorganisms, including bacteria, fungi, parasites, viruses, and yeast.
“Nitric oxide (NO) has antimicrobial activity against a growing list of microorganisms, including bacteria, fungi, parasites, viruses, and yeast.20,111,120,127,177,281,282”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [120]
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References 192 · Cited by 194
Research works printed but not linked: 8
- [12]Ostrovsky AD Ford PC Dalton Trans 2009 28 10660 20023893
- [32]Morley D Keefer LK J Cardiovasc Pharmacol 1993 22 S3 7504766
- [45]Martínez-Ruiz A Cadenas S Lamas S Free Radical Biol Med 2011 51 17 21549190
- [57]Eroy-Reveles AA Mascharak PK Future Med Chem 2009 1 1497 21426062
- [85]Eroy-Reveles AA Leung Y Mascharak PK J Am Chem Soc 2006 128 7166 16734462
- [86]Eroy-Reveles AA Leung Y Beavers CM Olmstead MM Mascharak PK J Am Chem Soc 2008 130 4447 18335935
- [92]Marquele-Oliveira F Santana DC Taveira SF Vermeulen DM de Oliveira AR da Silva RS Lopez RF J Pharm Biomed Anal 2010 53 843 20634015
- [134]Sehba FA Bederson JB Early Brain Injury or Cerebral Vasospasm 110/1 Feng H Mao Y Zhang JH Springer Vienna 2011 99
- Authors
- Jen, M. C., Serrano, M. C., van Lith, R., & Ameer, G. A.
- Affiliations
- Northwestern University (US)
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Ameer, Guillermo A.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2011-11-17
- Volume
- 22
- Issue
- 2
- Pages
- 239-260
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- PMC
- PMC4111277
- OpenAlex
- W2065359321
- Cited by
- 194
- References
- 192
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 9 · 2023: 16 · 2022: 15 · 2021: 21 · 2020: 14 · 2019: 15 · 2018: 15 · 2017: 14 · 2016: 9 · 2015: 15 · 2014: 12 · 2013: 10 · 2012: 2
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Functional Materials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM008449)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- nitric oxide, nitric oxide therapy, controlled release kinetics, in vivo applications, biomedical applications, cardiovascular homeostasis, wound healing, bone metabolism, neurotransmission
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