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Cited by 133Tissue Engineering and Regenerative Medicine3D Printing in Biomedical ResearchElectrospun Nanofibers in Biomedical Applications

"Tissue Papers" from organ-specific decellularized extracellular matrices

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Jakus, Adam E., Laronda, Monica M., Rashedi, Alexandra S., Robinson, Christina M., Lee, Chris, Jordan, Sumanas W., Orwig, Kyle E., Woodruff, Teresa K. +1 more·2017·Advanced Functional Materials
DOI 10.1002/adfm.201700992PMC PMC5665058
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Abstract

Using an innovative, tissue‐independent approach to decellularized tissue processing and biomaterial fabrication, the development of a series of “tissue papers” derived from native porcine tissues/organs (heart, kidney, liver, muscle), native bovine tissue/organ (ovary and uterus), and purified bovine Achilles tendon collagen as a control from decellularized extracellular matrix particle ink suspensions cast into molds is described. Each tissue paper type has distinct microstructural characteristics as well as physical and mechanical properties, is capable of absorbing up to 300% of its own weight in liquid, and remains mechanically robust (E = 1–18 MPa) when hydrated; permitting it to be cut, rolled, folded, and sutured, as needed. In vitro characterization with human mesenchymal stem cells reveals that all tissue paper types support cell adhesion, viability, and proliferation over four weeks. Ovarian tissue papers support mouse ovarian follicle adhesion, viability, and health in vitro, as well as support, and maintain the viability and hormonal function of nonhuman primate and human follicle‐containing, live ovarian cortical tissues ex vivo for eight weeks postmortem. “Tissue papers” can be further augmented with additional synthetic and natural biomaterials, as well as integrated with recently developed, advanced 3D‐printable biomaterials, providing a versatile platform for future multi‐biomaterial construct manufacturing.

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  • Present academic-scale production, frequently dependent on tedious, labor-based, hand-tissue-processing, is inadequate for creation of large, consistent, GMP-compliant production quantities needed for clinical trials and commercial production.

    “Present academic-scale production, frequently dependent upon tedious, labor-based, hand-tissue-processing, is inadequate for the creation of the large, consistent, GMP-compliant, production quantities needed when performing clinical trials and commercial production [52].”

    From From scaffold to function: A systematic review on dLECM-based hydrogels for liver tissue engineering — Fabrication, properties, and translational applications (2026) · cites this paper as [52]

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References 73 · Cited by 133

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Authors
Jakus, A. E., Laronda, M. M., Rashedi, A. S., Robinson, C. M., Lee, C., Jordan, S. W., Orwig, K. E., Woodruff, T. K., & Shah, R. N.
Affiliations
  • Northwestern University (US)
  • University of Pittsburgh (US)
Corresponding author
Shah, Ramille N.
ORCID
Venue
Advanced Functional Materials
Publisher
Wiley
Published
2017-08-07
Volume
27
Issue
34
ISSN
  • 1616-301X (ISSN-L)
  • 1616-3028
DOI
10.1002/adfm.201700992
PMC
PMC5665058
OpenAlex
W2742852515
Cited by
133
References
73
Citations by year
2026: 5 · 2025: 9 · 2024: 10 · 2023: 13 · 2022: 18 · 2021: 24 · 2020: 23 · 2019: 17 · 2018: 13 · 2017: 1
FWCI
15.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Advanced Functional Materials (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Army Research Office
  • Medical Research and Materiel Command
  • Northwestern University
  • Google
  • National Cancer Institute (CCSG P30 CA060553, CA060553;)
  • Ecumenical Project for International Cooperation (NSFDMR‐1121262, EEC‐0118025|003;)
  • Office of Naval Research (N00014‐11‐1‐0690)
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords
decellularized extracellular matrix, tissue paper, porcine organs, bovine ovarian tissue, ovarian cortical tissue, mesenchymal stem cells, tissue engineering scaffolds

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