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Electrospun Nanofibers for Regenerative Medicine
Open accessAbstract
This Progress Report reviews recent progress in applying electrospun nanofibers to the emerging field of regenerative medicine. It begins with a brief introduction to electrospinning and nanofibers, with a focus on issues related to the selection of materials, incorporation of bioactive molecules, degradation characteristics, control of mechanical properties, and facilitation of cell infiltration. Next, a number of approaches to fabricate scaffolds from electrospun nanofibers are discussed, including techniques for controlling the alignment of nanofibers and for producing scaffolds with complex architectures. The article also highlights applications of the nanofiber‐based scaffolds in four areas of regenerative medicine that involve nerves, dural tissues, tendons, and the tendon‐to‐bone insertion site. The Progress Report concludes with perspectives on challenges and future directions for design, fabrication, and utilization of scaffolds based on electrospun nanofibers.
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Cited by
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
Silk fibroin as a functional biomaterial for tissue engineering
Sun, W., Gregory, D. A., Tomeh, M. A., & Zhao, X. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031499 · Cited by 552
Improved Cellular Infiltration in Electrospun Fiber via Engineered Porosity
Nam, J., Huang, Y., Agarwal, S., & Lannutti, J. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0306 · Cited by 414
Polymeric nanostructured materials for biomedical applications
Tang, Z., He, C., Tian, H., Ding, J., Hsiao, B. S., Chu, B., & Chen, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.05.005 · Cited by 363
Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review
Yu, D.-G., Li, J.-J., Williams, G. R., & Zhao, M. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.08.016 · Cited by 341
Metadata
- Authors
- Liu, W., Thomopoulos, S., & Xia, Y.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2011-12-16
- Volume
- 1
- Issue
- 1
- Pages
- 10-25
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2046774273
- Cited by
- 550
- References
- 4
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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