The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Gel Scaffolds of BMP‐2‐Binding Peptide Amphiphile Nanofibers for Spinal Arthrodesis
Open accessAbstract
Peptide amphiphile (PA) nanofibers formed by self‐assembly can be customized for specific applications in regenerative medicine through the use of molecules that display bioactive signals on their surfaces. Here, the use of PA nanofibers with binding affinity for the bone promoting growth factor BMP‐2 to create a gel scaffold for osteogenesis is reported. With the objective of reducing the amount of BMP‐2 used clinically for successful arthrodesis in the spine, amounts of growth factor incorporated in the scaffolds that are 10 to 100 times lower than that those used clinically in collagen scaffolds are used. The efficacy of the bioactive PA system to promote BMP‐2‐induced osteogenesis in vivo is investigated in a rat posterolateral lumbar intertransverse spinal fusion model. PA nanofiber gels displaying BMP‐2‐binding segments exhibit superior spinal fusion rates relative to controls, effectively decreasing the required therapeutic dose of BMP‐2 by 10‐fold. Interestingly, a 42% fusion rate is observed for gels containing the bioactive nanofibers without the use of exogenous BMP‐2, suggesting the ability of the nanofiber to recruit endogenous growth factor. Results obtained here demonstrate that bioactive biomaterials with capacity to bind specific growth factors by design are great targets for regenerative medicine.
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“Similar work has shown promise in stem cell differentiation and neural regeneration following spinal injury in vivo200–202, further demonstrating the utility of peptide-based materials in cell culture.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [201]
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Cites
Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers
Hartgerink, J. D., Beniash, E., & Stupp, S. I. (2001) · Science · doi:10.1126/science.1063187 · Cited by 3,607
Self-citationLee, K., Silva, E. A., & Mooney, D. J. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0223 · Cited by 1,424
Designing materials to direct stem-cell fate
Lütolf, M. P., Gilbert, P. M., & Blau, H. M. (2009) · Nature · doi:10.1038/nature08602 · Cited by 1,409
Role of morphogenetic proteins in skeletal tissue engineering and regeneration
Reddi, A. H. (1998) · Nature Biotechnology · doi:10.1038/nbt0398-247 · Cited by 831
Tysseling, V. M., Sahni, V., Niece, K. L., Birch, D. V., Czeisler, C. M., Fehlings, M. G., Stupp, S. I., & Kessler, J. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0143-08.2008 · Cited by 680
Self-citationSynergistic control of cell adhesion by integrins and syndecans
Morgan, M. R., Humphries, M. J., & Bass, M. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2289 · Cited by 608
Supramolecular design of self-assembling nanofibers for cartilage regeneration
Shah, R. N., Shah, N. A., Lim, M., Hsieh, C., Nuber, G., & Stupp, S. I. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906501107 · Cited by 543
Self-citationTuning Supramolecular Rigidity of Peptide Fibers through Molecular Structure
Pashuck, E. T., Cui, H., & Stupp, S. I. (2010) · Journal of the American Chemical Society · doi:10.1021/ja908560n · Cited by 440
Self-citationHeparin Binding Nanostructures to Promote Growth of Blood Vessels
Rajangam, K. L., Behanna, H. A., Hui, M. J., Han, X., Hulvat, J. F., Lomasney, J. W., & Stupp, S. I. (2006) · Nano Letters · doi:10.1021/nl0613555 · Cited by 417
Self-citationSupramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair
Webber, M. J., Tongers, J., Newcomb, C. J., Marquardt, K.-T., Bauersachs, J. K., Losordo, D. W., & Stupp, S. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016546108 · Cited by 324
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Webber, M. J., Appel, E. A., Meijer, E. W., & Langer, R. (2015) · Nature Materials · doi:10.1038/nmat4474 · Cited by 1,609
Drug delivery by supramolecular design
Webber, M. J., & Langer, R. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00391a · Cited by 828
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“Current methodologies employed in the fabrication of nanocomposites include electrospinning [232], molecular self-assembly [233], and more commonly, composite formation with nanomaterials such as carbon nanotubes [234,235] and nanohydroxyapatite [236,237] as discussed below.”
Towards organoid culture without Matrigel
Kozlowski, M. T., Crook, C. J., & Ku, H. T. (2021) · Communications Biology · doi:10.1038/s42003-021-02910-8 · Cited by 409
Jakus, A. E., Rutz, A. L., Jordan, S. W., Kannan, A. S., Mitchell, S. M., Yun, C., Koube, K. D., Yoo, S. C., Whiteley, H. E., Richter, C., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf7704 · Cited by 397
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Metadata
- Authors
- Lee, S. S., Hsu, E. L., Mendoza, M., Ghodasra, J., Nickoli, M. S., Ashtekar, A., Polavarapu, M., Babu, J., Riaz, R. M., Nicolas, J. D., Nelson, D., Hashmi, S. Z., Kaltz, S. R., Earhart, J. S., Merk, B. R., McKee, J. S., Bairstow, S. F., Shah, R. N., Hsu, W. K., & Stupp, S. I.
- Affiliations
- Northwestern University (US)
- Baxter (United States) (US)
- Corresponding author
- Stupp, Samuel I.
- ORCID
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2014-04-22
- Volume
- 4
- Issue
- 1
- Pages
- 131-141
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- PMC
- PMC4206675
- OpenAlex
- W2041261315
- Cited by
- 183
- References
- 48
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 11 · 2023: 13 · 2022: 15 · 2021: 22 · 2020: 19 · 2019: 18 · 2018: 18 · 2017: 16 · 2016: 20 · 2015: 12 · 2014: 2
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Healthcare Materials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of Dental and Craniofacial Research (R01DE015920)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- peptide amphiphile nanofibers, spinal fusion, bone formation, growth factor delivery, self-assembly, posterolateral lumbar fusion, regenerative medicine
- MeSH terms
- Animals, Cell Line, Disease Models, Animal, Female, Osteogenesis, Peptides, Spinal Diseases, Spinal Fusion, Rats, Sprague-Dawley, Implants, Experimental, Mice, Rats, Tissue Scaffolds, Bone Morphogenetic Protein 2, Nanofibers
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