Applications of Nanoparticles in Biology
Open accessAbstract
The wide variety of core materials available, coupled with tunable surface properties, make nanoparticles an excellent platform for a broad range of biological and biomedical applications. This Review provides an introduction to nanoparticle–biomolecular interactions as well as recent applications of nanoparticles in biological sensing, delivery, and imaging of live cells and tissues. magnified image
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The functionalized NPs possess unique advantages over antibody-based platforms: comparable size and diffusion kinetics to proteins, high surface area per volume and high number of flexible binding sites, and inexpensive, simple, fast, scalable synthesis with minimal batch-to-batch variability.
“These results highlight the unique advantages that these functionalized NPs possess for protein enrichment over antibody-based platforms: (a) comparable size and diffusion kinetics to proteins, promoting effective capture of low-abundance proteins within complex mixtures20,47,48; (b) high surface area per volume and high number of flexible binding sites, contributing to high ligand density and”
From Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum (2020) · cites this paper as [48]
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References 171 · Cited by 1,547
- Authors
- De, M., Ghosh, P. S., & Rotello, V. M.
- Affiliations
- University of Massachusetts Amherst (US)
- Corresponding author
- Rotello, Vincent M.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2008-11-13
- Volume
- 20
- Issue
- 22
- Pages
- 4225-4241
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W1999046940
- Cited by
- 1,547
- References
- 171
- Citations by year
- 2026: 25 · 2025: 38 · 2024: 67 · 2023: 56 · 2022: 60 · 2021: 79 · 2020: 71 · 2019: 60 · 2018: 78 · 2017: 93 · 2016: 108 · 2015: 106 · 2014: 118 · 2013: 152 · 2012: 125
- FWCI
- 44.51
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Advanced Materials (publishedVersion)
- ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion, cc-by-nc-nd)
- ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanotechnology research and applications
- Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
- Keywords
- nanoparticles, nanoparticle-biomolecule interactions, biosensing, drug delivery, live-cell imaging, tissue imaging, biomedical applications
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