Catalase‐Loaded TaOx Nanoshells as Bio‐Nanoreactors Combining High‐Z Element and Enzyme Delivery for Enhancing Radiotherapy
Abstract
A novel type of bio-nanoreactor with catalase loaded inside TaOx hollow nanoshells is fabricated via a mild one-step method. Such bio-nanoreactors could efficiently improve the tumor oxygenation by supplying oxygen via decomposition of endogenic H2 O2 in a tumor microenvironment, and thus synergistically enhance the efficacy of cancer radiotherapy by both depositing radiation energy within the tumor and overcoming hypoxia-induced radiotherapy resistance.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Song designed a bionanoreactor encapsulating CAT in tantalum oxide nanoshells (TaOx@Cat) to decompose tumor endogenous H2O2 and relieve tumor hypoxia.
“Song designed a novel bionanoreactor to decompose tumor endogenous H2O2 and relieve tumor hypoxia by encapsulating CAT in tantalum oxide (TaOx) nanoshells, resulting in TaOx@Cat nanoparticles.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [238]
The citation lists haven’t been fetched yet
References 41 · Cited by 394
- Authors
- Song, G., Chen, Y., Liang, C., Yi, X., Liu, J., Sun, X., Shen, S., Yang, K., & Liu, Z.
- Affiliations
- Soochow University (CN)
- Corresponding author
- Liu, Zhuang
- ORCID
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2016-06-08
- Volume
- 28
- Issue
- 33
- Pages
- 7143-7148
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2417259144
- Cited by
- 394
- References
- 41
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 26 · 2023: 33 · 2022: 49 · 2021: 54 · 2020: 64 · 2019: 56 · 2018: 44 · 2017: 40 · 2016: 6
- FWCI
- 23.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Priority Academic Program Development of Jiangsu Higher Education Institutions, and Post-doctoral science foundation of China (2014M561706)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- catalase, tantalum oxide, hollow nanoshells, radiotherapy enhancement, tumor hypoxia, tumor oxygenation, hydrogen peroxide decomposition, high-Z elements, enzyme delivery, synergistic cancer therapy
- MeSH terms
- Animals, Catalase, Neoplasms, Oxygen, Mice, Nanoshells, Tumor Microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
