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Cited by 231

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Self‐Powered Intracellular Drug Delivery by a Biomechanical Energy‐Driven Triboelectric Nanogenerator

Liu, Zhirong, Nie, Jinhui, Miao, Bin, Li, Jiadong, Cui, Yuanbo, Wang, Shu, Zhang, Xiaodi, Zhao, Gengrui, Deng, Yongbo, Wu, Yihui, Li, Zhou, Li, Linlin, Wang, Zhong Lin·2019·Advanced Materials

Abstract

Nondestructive, high‐efficiency, and on‐demand intracellular drug/biomacromolecule delivery for therapeutic purposes remains a great challenge. Herein, a biomechanical‐energy‐powered triboelectric nanogenerator (TENG)‐driven electroporation system is developed for intracellular drug delivery with high efficiency and minimal cell damage in vitro and in vivo. In the integrated system, a self‐powered TENG as a stable voltage pulse source triggers the increase of plasma membrane potential and membrane permeability. Cooperatively, the silicon nanoneedle‐array electrode minimizes cellular damage during electroporation via enhancing the localized electrical field at the nanoneedle–cell interface and also decreases plasma membrane fluidity for the enhancement of molecular influx. The integrated system achieves efficient delivery of exogenous materials (small molecules, macromolecules, and siRNA) into different types of cells, including hard‐to‐transfect primary cells, with delivery efficiency up to 90% and cell viability over 94%. Through simple finger friction or hand slapping of the wearable TENGs, it successfully realizes a transdermal biomolecule delivery with an over threefold depth enhancement in mice. This integrated and self‐powered system for active electroporation drug delivery shows great prospect for self‐tuning drug delivery and wearable medicine.

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Metadata

Authors
Liu, Z., Nie, J., Miao, B., Li, J., Cui, Y., Wang, S., Zhang, X., Zhao, G., Deng, Y., Wu, Y., Li, Z., Li, L., & Wang, Z. L.
Venue
Advanced Materials
Publisher
Wiley
Published
2019-02-05
Volume
31
Issue
12
Pages
e1807795-e1807795
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
OpenAlex
W2913570441
Cited by
231
References
2
FWCI
11.46
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Self‐Powered Intracellular Drug Delivery by a Biomechanical Energy‐Driven Triboelectric Nanogenerator. https://app.cochat.ai/papers/10.1002/adma.201807795
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Liu, Z., Nie, J., Miao, B., Li, J., Cui, Y., Wang, S., Zhang, X., Zhao, G., Deng, Y., Wu, Y., Li, Z., Li, L., & Wang, Z. L. (2019). Self‐Powered Intracellular Drug Delivery by a Biomechanical Energy‐Driven Triboelectric Nanogenerator. Advanced Materials. https://doi.org/10.1002/adma.201807795

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