The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Self‐Powered Intracellular Drug Delivery by a Biomechanical Energy‐Driven Triboelectric Nanogenerator
Abstract
Nondestructive, high‐efficiency, and on‐demand intracellular drug/biomacromolecule delivery for therapeutic purposes remains a great challenge. Herein, a biomechanical‐energy‐powered triboelectric nanogenerator (TENG)‐driven electroporation system is developed for intracellular drug delivery with high efficiency and minimal cell damage in vitro and in vivo. In the integrated system, a self‐powered TENG as a stable voltage pulse source triggers the increase of plasma membrane potential and membrane permeability. Cooperatively, the silicon nanoneedle‐array electrode minimizes cellular damage during electroporation via enhancing the localized electrical field at the nanoneedle–cell interface and also decreases plasma membrane fluidity for the enhancement of molecular influx. The integrated system achieves efficient delivery of exogenous materials (small molecules, macromolecules, and siRNA) into different types of cells, including hard‐to‐transfect primary cells, with delivery efficiency up to 90% and cell viability over 94%. Through simple finger friction or hand slapping of the wearable TENGs, it successfully realizes a transdermal biomolecule delivery with an over threefold depth enhancement in mice. This integrated and self‐powered system for active electroporation drug delivery shows great prospect for self‐tuning drug delivery and wearable medicine.
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Cites
Triboelectric nanogenerators for sensitive nano-coulomb molecular mass spectrometry
Li, A., Zi, Y., Guo, H., Wang, Z. L., & Fernández, F. M. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.17 · Cited by 324
Self-citationSelf‐Powered Water Splitting Using Flowing Kinetic Energy
Tang, W., Han, Y., Han, C. B., Gao, C. Z., Cao, X., & Wang, Z. L. (2015) · Advanced Materials · doi:10.1002/adma.201404071 · Cited by 223
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Cited by
Choi, D., Lee, Y., Lin, Z.-H., Cho, S., Kim, M., Ao, C. K., Soh, S., Sohn, C., Jeong, C. K., Lee, J., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c12458 · Cited by 656
Self-citationProbing Contact‐Electrification‐Induced Electron and Ion Transfers at a Liquid–Solid Interface
Nie, J., Ren, Z., Xu, L., Lin, S., Zhan, F., Chen, X., & Wang, Z. L. (2020) · Advanced Materials · doi:10.1002/adma.201905696 · Cited by 593
Self-citationLiu, Z., Wan, X., Wang, Z. L., & Li, L. (2021) · Advanced Materials · doi:10.1002/adma.202007429 · Cited by 478
Self-citationLiang, X., Jiang, T., Liu, G., Feng, Y., Zhang, C., & Wang, Z. L. (2020) · Energy & Environmental Science · doi:10.1039/c9ee03258d · Cited by 398
Self-citationChen, P., An, J., Shu, S., Cheng, R., Nie, J., Jiang, T., & Wang, Z. L. (2021) · Advanced Energy Materials · doi:10.1002/aenm.202003066 · Cited by 339
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Metadata
- Authors
- Liu, Z., Nie, J., Miao, B., Li, J., Cui, Y., Wang, S., Zhang, X., Zhao, G., Deng, Y., Wu, Y., Li, Z., Li, L., & Wang, Z. L.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2019-02-05
- Volume
- 31
- Issue
- 12
- Pages
- e1807795-e1807795
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2913570441
- Cited by
- 231
- References
- 2
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, Z., Nie, J., Miao, B., Li, J., Cui, Y., Wang, S., Zhang, X., Zhao, G., Deng, Y., Wu, Y., Li, Z., Li, L., & Wang, Z. L. (2019). Self‐Powered Intracellular Drug Delivery by a Biomechanical Energy‐Driven Triboelectric Nanogenerator. Advanced Materials. https://doi.org/10.1002/adma.201807795
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