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Cited by 41Nanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials

Maximum Emission Peak Over 1500 nm of Organic Assembly for Blood–Brain Barrier‐Crossing NIR‐IIb Phototheranostics of Orthotopic Glioblastoma

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Zhao, Feng, Zhang, Xinming, Bai, Fang, Lei, Shan, He, Gang, Huang, Peng, Lin, Jing·2023·Advanced Materials
DOI 10.1002/adma.202208097
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Abstract

The development of blood–brain barrier (BBB)‐crossing phototheranostic agents in second near‐infrared window (NIR‐II), especially in the range of 1500–1700 nm (NIR‐IIb), affords great opportunities for glioblastoma (GBM) management. Herein, an organic assembly (denoted as LET‐12) with the maximum absorption peak at 1400 nm and emission peak at 1512 nm with trailing over 1700 nm through the self‐assembly of organic small molecule IR‐1064 is designed and subsequently decorated with choline and acetylcholine analogs. The LET‐12 can effectively cross BBB through the brain's choline‐like receptors‐mediated transcytosis and accumulated in tumor tissues, thus achieving fluorescence/photoacoustic (FL/PA) duplex imaging of orthotopic GBM with ≈3.0 mm depth and a superior tumor‐to‐normal tissue signal ratio (20.93 ± 0.59 for FL imaging and 32.63 ± 1.16 for PA imaging, respectively). Owing to its good photothermal conversion ability, the LET‐12 also can serve as a photothermal conversion agent, achieving obvious tumor repression of orthotopic murine GBM model after once treatment. The findings indicate that the LET‐12 holds great potential for BBB‐crossing NIR‐IIb phototheranostics of orthotopic GBM. This self‐assembly strategy of organic small molecules opens a new avenue for the construction of NIR‐IIb phototheranostics.

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References 69 · Cited by 41

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  1. M. E. Davis, Clin. J. Oncol. Nurs. 2016, 20, S2;
  2. M. Lim, Y. Xia, C. Bettegowda, M. Weller, Nat. Rev. Clin. Oncol. 2018, 15, 422.
  3. E. Neuwelt, N. J. Abbott, L. Abrey, W. A. Banks, B. Blakley, T. Davis, B. Engelhardt, P. Grammas, M. Nedergaard, J. Nutt, W. Pardridge, G. A. Rosenberg, Q. Smith, L. R. Drewes, Lancet Neurol. 2008, 7, 84;
  4. H. Sarin, A. S. Kanevsky, H. Wu, K. R. Brimacombe, S. H. Fung, A. A. Sousa, S. Auh, C. M. Wilson, K. Sharma, M. A. Aronova, R. D. Leapman, G. L. Griffiths, M. D. Hall, J. Transl. Med. 2008, 6, 80;
  5. W. Tang, W. Fan, J. Lau, L. Deng, Z. Shen, X. Chen, Chem. Soc. Rev. 2019, 48, 2967.
  6. K. J. Langen, N. Galldiks, E. Hattingen, N. J. Shah, Nat. Rev. Neurol. 2017, 13, 279.
  7. S. Zhu, R. Tian, A. L. Antaris, X. Chen, H. Dai, Adv. Mater. 2019, 31, 1900321;
  8. M. Zhang, J. Yue, R. Cui, Z. Ma, H. Wan, F. Wang, S. Zhu, Y. Zhou, Y. Kuang, Y. Zhong, D. W. Pang, H. Dai, Proc. Natl. Acad. Sci. USA 2018, 115, 6590;
  9. Q. Fu, R. Zhu, J. Song, H. Yang, X. Chen, Adv. Mater. 2019, 31, 1805875;
  10. U. Chitgupi, N. Nyayapathi, J. Kim, D. Wang, B. Sun, C. Li, K. Carter, W. C. Huang, C. Kim, J. Xia, J. F. Lovell, Adv. Mater. 2019, 31, 1902279;
  11. F. Zhang, B. Z. Tang, Chem. Sci. 2021, 12, 3377;
  12. B. Li, M. Zhao, J. Lin, P. Huang, X. Chen, Chem. Soc. Rev. 2022, 51, 7692.
  13. P. Huang, P. Rong, A. Jin, X. Yan, M. Zhang, J. Lin, H. Hu, X. Yue, Z. Wang, W. Li, G. Niu, W. Zeng, W. Wang, X. Chen, Adv. Mater. 2014, 26, 6401;
  14. P. Huang, Y. Gao, J. Lin, H. Hu, H. S. Liao, X. Yan, Y. Tang, A. Jin, J. Song, G. Niu, G. Zhang, F. Horkay, X. Chen, ACS Nano 2015, 9, 9517;
  15. X. Gao, S. Jiang, C. Li, Y. Chen, Y. Zhang, P. Huang, J. Lin, Biomaterials 2021, 267, 120454;
  16. J. Li, J. Wang, J. Zhang, T. Han, X. Hu, M. M. S. Lee, D. Wang, B. Z. Tang, Adv. Mater. 2021, 33, 2105999;
  17. J. Liu, S. He, Y. Luo, Y. Zhang, X. Du, C. Xu, K. Pu, J. Wang, Adv. Mater. 2022, 34, 2106654.
  18. Wang, Y. Liu , M. Morsch, Y. Lu, S. Ping, L. Han, Z. Wang, X. Chen, C. Song, S. Liu, B. Shi, B. Z. Tang, Adv. Mater. 2022, 34, 2106082;
  19. Y. Yuan, Z. Feng, S. Li, Z. Huang, Y. Wan, C. Cao, S. Lin, L. Wu, J. Zhou, L. S. Liao, J. Qian, C. S. Lee, Adv. Mater. 2022, 34, 2201263;
  20. Y. Yang, C. Sun, S. Wang, K. Yan, M. Zhao, B. Wu, F. Zhang, Angew. Chem., Int. Ed. 2022, 61, 2021174;
  21. S. Song, Y. Wang, Y. Zhao, W. Huang, F. Zhang, S. Zhu, Q. Wu, S. Fu, B. Z. Tang, D. Wang, Matter 2022, 6, 30.
  22. G. Hong, J. Robinson, Y. Zhang, S. Diao, A. Antaris, Q. Wang, H. Dai, Angew. Chem., Int. Ed. 2012, 51, 9818;
  23. H. Li, M. Wang, B. Huang, S. W. Zhu, J. J. Zhou, D. R. Chen, R. Cui, M. Zhang, Z. J. Sun, Nat. Commun. 2021, 12, 7149;
  24. H. Yang, H. Huang, X. Ma, Y. Zhang, X. Yang, M. Yu, Z. Sun, C. Li, F. Wu, Q. Wang, Adv. Mater. 2021, 33, 2103953;
  25. Z. Luo, D. Hu, D. Gao, Z. Yi, H. Zheng, Z. Sheng, X. Liu, Adv. Mater. 2021, 33, 2102950;
  26. P. Pei, Y. Chen, C. Sun, Y. Fan , Y. Yang, X. Liu, L. Lu, M. Zhao, H. Zhang, D. Zhao , X. Liu , F. Zhang, Nat. Nanotechnol. 2021, 16, 1011.
  27. C. Li, W. Li, H. Liu, Y. Zhang, G. Chen, Z. Li, Q. Wang, Angew. Chem., Int. Ed. 2020, 59, 247;
  28. T. Wang, S. Wang, Z. Liu, Z. He, P. Yu, M. Zhao, H. Zhang, L. Lu, Z. Wang, Z. Wang, W. Zhang, Y. Fan, C. Sun, D. Zhao, W. Liu, J. G. Bunzli, F. Zhang, Nat. Mater. 2021, 20, 1571.
  29. X. Hu, Z. Chen, A. Jin, Z. Yang, D. Gan, A. Wu, H. Ao, W. Huang, Q. Fan, Small 2021, 17, 2007566;
  30. C. Xu, K. Pu, Chem. Soc. Rev. 2021, 50, 1111;
  31. H. Dai, X. Wang, J. Shao, W. Wang, X. Mou, X. Dong, Small 2021, 17, 2102646;
  32. J. Li, X. Yu, Y. Jiang, S. He, Y. Zhang, Y. Luo, K. Pu, Adv. Mater. 2021, 33, 2003458;
  33. L. Wu, Y. Ishigaki, W. Zeng, T. Harimoto, B. Yin, Y. Chen, S. Liao, Y. Liu, Y. Sun, X. Zhang, Y. Liu, Y. Liang, P. Sun, T. Suzuki, G. Song, Q. Fan, D. Ye, Nat. Commun. 2021, 12, 6145;
  34. X. Zhang, C. Jiang, T. He, F. Zhao, J. Qu, P. Huang, J. Lin, Anal. Chem. 2022, 94, 3227.
  35. S. Wang, J. Lin, T. Wang, X. Chen, P. Huang, Theranostics 2016, 6, 2394;
  36. J. Li, R. Jiang, Q. Wang, X. Li, X. Hu, Y. Yuan, X. Lu, W. Wang, W. Huang, Q. Fan, Biomaterials 2019, 217, 119304;
  37. K. Huang, Y. Zhang, J. Lin, P. Huang, Biomater. Sci. 2019, 7, 472;
  38. C. Ou, W. Na, W. Ge, H. Huang, F. Gao, L. Zhong, Y. Zhao, X. Dong, Angew. Chem., Int. Ed. 2021, 60, 8157;
  39. K. Jiang, S. Jiang, F. Zhao, P. Chen, P. Huang, J. Lin, Anal. Chem. 2022, 94, 13770;
  40. Y. Liu, X. Zhang, S. Lei, P. Huang, J. Lin, Trends Chem. 2023, 5, 11;
  41. Y. Liu, X. Zhang, S. Lei, P. Huang, J. Lin, Mater. Chem. Front. 2023, 7, 775.
  42. C. S. Lee, K. W. Leong, Curr. Opin. Biotechnol. 2020, 66, 78;
  43. D. Wu, M. Qin, D. Xu, L. Wang, C. Liu, J. Ren, G. Zhou, C. Chen, F. Yang, Y. Li, Y. Zhao, R. Huang, S. Pourtaheri, C. Kang, M. Kamata, I. S. Y. Chen, Z. He, J. Wen, W. Chen, Y. Lu, Adv. Mater. 2019, 31, 1807557.
  44. S. Lei, F. Zhao, J. Zhang, N. Blum, T. He, J. Qu, P. Huang, J. Lin, Anal. Chem. 2022, 94, 8399.
  45. S. Dahne, Science 1978, 199, 1163;
  46. T. Tanaka, T. Matsubara, J. Imaging Sci. Technol. 1993, 37, 585;
  47. J. L. Bricks, Y. L. Slominskii, I. D. Panas, A. P. Demchenko, Methods Appl. Fluoresc. 2017, 6, 012001;
  48. L. Dahne, E. Biller, H. Baumgartel, Angew. Chem., Int. Ed. 1998, 37, 646;
  49. M. Li, A. Wang, G. Mao, L. Daehne, J. Phys. Chem. B 1999, 103, 11161.
  50. L. Zhao, S. Li, Y. Liu, R. Xing, X. Yan, CCS Chem. 2019, 1, 173;
  51. L. Zhao, X. Ren, X. Yan, CCS Chem. 2021, 3, 678.
  52. A. Chibisov, T. Slavnova, H. Görner, Chem. Phys. Lett. 2010, 498, 63.
  53. F. Rotermund, R. Weigand, A. Penzkofer, Chem. Phys. 1997, 220, 385;
  54. R. Liu, J. Tang, Y. Xu, Y. Zhou, Z. Dai, Nanotheranostics 2017, 1, 430.
  55. P. Kumar, H. Wu, J. L. McBride, K. E. Jung, M. H. Kim, B. L. Davidson, S. K. Lee, P. Shankar, N. Manjunath, Nature 2007, 448, 39;
  56. N. J. Abbott, L. Ronnback, E. Hansson, Nat. Rev. Neu- rosci. 2006, 7, 41.
  57. W. Yin, L. Yan, J. Yu, G. Tian, L. Zhou, X. Zheng, X. Zhang, Y. Yong, J. Li, Z. Gu, Y. Zhao, ACS Nano 2014, 8, 6922;
  58. T. Liu, C. Wang, X. Gu, H. Gong, L. Cheng, X. Shi, L. Feng, B. Sun, Z. Liu, Adv. Mater. 2014, 26, 3433.
  59. C. Chaffer, R. Weinberg, Science 2011, 331, 1559;
  60. J. Joyce, J. Pollard, Nat. Rev. Cancer 2009, 9, 239.
  61. P. Friedl, S. Alexander, Cell 2011, 147, 992;
  62. H. Zou, W. Yue, W. Yu, D. Liu, C. Fong, J. Zhao, M. Yang, Anal. Chem. 2015, 87, 7098.
  63. M. Olson, E. Sahai, Clin. Exp. Metastasis 2009, 26, 273;
  64. C. Fife, J. McCarroll, M. Kavallaris, Br. J. Pharmacol. 2014, 171, 5507;
  65. J. Liu, L. Kang, S. Smith, C. Wang, Nano Lett. 2021, 21, 9609.
  66. H. Faulstich, S. Zobeley, G. Rinnerthaler, J. Small, J. Muscle Res. Cell Motil. 1988, 9, 370;
  67. Y. Harada, A. Noguchi, A. Kishino, T. Yanagida, Nature 1987, 326, 805;
  68. S. Kron, J. Spudich, Proc. Natl. Acad. Sci. USA. 1986, 83, 6272.
  69. S. Irtenkauf, S. Sobiechowski, L. Hasselbach, K. Nelson, A. Transou, E. Carlton, T. Mikkelsen, A. deCarvalho, Comp. Med. 2017, 67, 300.

Authors
Zhao, F., Zhang, X., Bai, F., Lei, S., He, G., Huang, P., & Lin, J.
Affiliations
Shenzhen University (CN)
Corresponding author
Lin, Jing
ORCID
Venue
Advanced Materials
Publisher
Wiley
Published
2023-04-07
Volume
35
Issue
22
Pages
e2208097-e2208097
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
DOI
10.1002/adma.202208097
OpenAlex
W4323656348
Cited by
41
References
69
Citations by year
2026: 7 · 2025: 18 · 2024: 15 · 2023: 1
FWCI
3.24
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Advanced Materials (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Shenzhen University
  • National Key Research and Development Program of China (2018YFA-0704000, 2020YFA0908800)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Keywords
blood-brain barrier penetration, glioblastoma, photoacoustic imaging, fluorescence imaging, photothermal therapy, orthotopic murine model
MeSH terms
Theranostic Nanomedicine, Animals, Blood-Brain Barrier, Fluorescence, Glioblastoma, Hyperthermia, Induced, Neoplasms, Phototherapy, Mice, Nanoparticles

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