The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Use of Copper Flow Reactor Technology for the Continuous Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles
Abstract
magnified image A library of 1,4‐disubstituted 1,2,3‐triazoles was synthesized using a copper flow reactor. Organic azides, generated in situ from alkyl halides and sodium azide, were reacted with acetylenes using the copper‐catalyzed Huisgen 1,3‐dipolar cycloaddition. This process eliminates both the handling of organic azides and the need for additional copper catalyst and permits the facile preparation of numerous triazoles in a continuous flow process.
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Cites
CuI‐Catalyzed Alkyne–Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective
Bock, V. D., Hiemstra, H., & van Maarseveen, J. H. (2006) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200500483 · Cited by 1,452
Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of Reagents
Song, H., & Ismagilov, R. F. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0354566 · Cited by 693
Cited by
The Hitchhiker’s Guide to Flow Chemistry
Plutschack, M. B., Pieber, B., Gilmore, K., & Seeberger, P. H. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00183 · Cited by 1,995
Taming hazardous chemistry by continuous flow technology
Movsisyan, M., Delbeke, E. I. P., Berton, J. K. E. T., Battilocchio, C., Ley, S. V., & Stevens, C. V. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00902b · Cited by 692
Metadata
- Authors
- Bogdan, A. R., & Sach, N. W.
- Venue
- Advanced Synthesis & Catalysis
- Publisher
- Wiley
- Published
- 2009-04
- Volume
- 351
- Issue
- 6
- Pages
- 849-854
- ISSN
- 1615-4150 (ISSN-L)
- 1615-4169
- OpenAlex
- W2047986469
- Cited by
- 159
- References
- 2
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Use of Copper Flow Reactor Technology for the Continuous Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles. https://app.cochat.ai/papers/10.1002/adsc.200800758
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- Bogdan, A. R., & Sach, N. W. (2009). The Use of Copper Flow Reactor Technology for the Continuous Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles. Advanced Synthesis & Catalysis. https://doi.org/10.1002/adsc.200800758
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
