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Multi‐Enzymatic Cascade Reactions: Overview and Perspectives
Abstract
Multi‐enzymatic cascade reactions, i.e., the combination of several enzymatic transformations in concurrent one‐pot processes, offer considerable advantages: the demand of time, costs and chemicals for product recovery may be reduced, reversible reactions can be driven to completion and the concentration of harmful or unstable compounds can be kept to a minimum. This review summarizes the developments in multi‐enzymatic cascades employed for the asymmetric synthesis of chiral alcohols, amines and amino acids, as well as for CC bond formation. In addition, a general classification of biocatalytic cascade systems is provided and bioprocess engineering aspects associated with the topic are discussed.
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Wingren, A., Galbe, M., & Zacchi, G. (2008) · Biotechnology Progress · doi:10.1021/bp0340180 · Cited by 675
Cited by
Role of Biocatalysis in Sustainable Chemistry
Sheldon, R. A., & Woodley, J. M. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00203 · Cited by 1,755
Barbosa, O., Torres, R., Ortiz, C., Berenguer-Murcia, Á., Rodrigues, R. C., & Fernandez-Lafuente, R. (2013) · Biomacromolecules · doi:10.1021/bm400762h · Cited by 494
Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis
Clouthier, C. M., & Pelletier, J. N. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15286j · Cited by 358
Nadar, S. S., & Rathod, V. K. (2019) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2018.12.015 · Cited by 73
Metadata
- Authors
- Ricca, E., Brucher, B., & Schrittwieser, J. H.
- Venue
- Advanced Synthesis & Catalysis
- Publisher
- Wiley
- Published
- 2011-08-25
- Volume
- 353
- Issue
- 13
- Pages
- 2239-2262
- ISSN
- 1615-4150 (ISSN-L)
- 1615-4169
- OpenAlex
- W1969968380
- Cited by
- 529
- References
- 1
- FWCI
- 10.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ricca, E., Brucher, B., & Schrittwieser, J. H. (2011). Multi‐Enzymatic Cascade Reactions: Overview and Perspectives. Advanced Synthesis & Catalysis. https://doi.org/10.1002/adsc.201100256
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