Antimicrobial Activity of Metal and Metal‐Oxide Based Nanoparticles
Abstract
With an increase in antibiotic resistance, a growing interest in developing new antimicrobial agents has gained popularity. Metal‐ and metal‐oxide‐based nanoparticles, surface‐to‐volume is able to distinguish bacterial cells from mammalian cells and can provide long‐term antibacterial and biofilm prevention. These nanoparticles elicit bactericidal properties through the generation of reactive oxygen species (ROS) that are able to target physical structures, metabolic pathways, and DNA synthesis of prokaryotic cells leading to cell death. In this progress report, a critical analysis of current literature on antimicrobial effect of metal and metal‐oxide nanoparticles are examined. Specifically, the antimicrobial mechanisms of metal ions and metal nanomaterials are discussed. Antimicrobial efficiency of nanomaterials is correlated with the structural and physical properties, such as size, shape, and/or zeta potential. A critical analysis of the current state of metal and metal‐oxide nanomaterial research advances our understanding to overcome antibiotic resistance and provide alternatives to combat bacterial infections. Finally, emerging approaches to identify and minimize metallic poisoning, specifically for biomedical applications, are examined.
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Antibiotic resistant bacteria (ARB) that harbor ARGs may present unique challenges for GSI such as limiting the biogeochemical processes, survival, and diversity of beneficial soil bacterial communities and vegetation.
“Antibiotic resistant bacteria (ARB) that harbor ARGs may present unique challenges for GSI such as limiting the biogeochemical processes, survival, and diversity of beneficial soil bacterial communities and vegetation (Gold et al., 2018; Shea and Moser, 2008).”
From Review of emerging contaminants in green stormwater infrastructure: antibiotic resistance genes, microplastics, tire wear particles, PFAS, and temperature (2024) · cites this paper as Gold et al., 2018
Removal of ARB/ARGs is complex and may rely on cellular defense and competition mechanisms, cellular nutrient uptake mechanisms, and charge, among others.
“Their removal is complex and therefore may rely on cellular defense and competition mechanisms, cellular nutrient uptake mechanisms, and charge, among others (Gold et al., 2018; Shea and Moser, 2008).”
From Review of emerging contaminants in green stormwater infrastructure: antibiotic resistance genes, microplastics, tire wear particles, PFAS, and temperature (2024) · cites this paper as Gold et al., 2018
Cites
Magiorakos, A.-P., Srinivasan, A., Carey, R. B., Carmeli, Y., Falagas, M. E., Giske, C. G., Harbarth, S., Hindler, J. F., Kahlmeter, G., Olsson-Liljequist, B., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2011.03570.x · Cited by 14,449 · see citing works
Hybrid antimicrobial enzyme and silver nanoparticle coatings for medical instruments
Eby, D. M., Luckarift, H. R., & Johnson, G. R. (2009) · ACS Applied Materials & Interfaces · doi:10.1021/am9002155 · Cited by 248 · see citing works
A battle for iron: host sequestration and Staphylococcus aureus acquisition
Haley, K. P., & Skaar, E. P. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2011.11.001 · Cited by 157 · see citing works
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Bodus, B., O'Malley, K., Dieter, G., Gunawardana, C., & McDonald, W. (2024) · Science of The Total Environment · doi:10.1016/j.scitotenv.2023.167195 · Cited by 76 · see citing works
Nanoparticles as Next-Generation Tooth-Whitening Agents: Progress and Perspectives
Kim, D.-H., Bae, J., Heo, J. H., Park, C. H., Kim, E. B., & Lee, J. H. (2022) · ACS Nano · doi:10.1021/acsnano.2c01412 · Cited by 50 · see citing works
- Authors
- Gold, K., Slay, B., Knackstedt, M., & Gaharwar, A. K.
- Affiliations
- Department of Biomedical Engineering Texas A&M University College Station TX 77843 USA
- Venue
- Advanced Therapeutics
- Publisher
- Wiley
- Published
- 2018-06-13
- Volume
- 1
- Issue
- 3
- ISSN
- 2366-3987
- Cited by
- 606
- References
- 3
- Language
- en
- Licence
- Funders
- National Institute of Biomedical Imaging and Bioengineering (EB026265, EB023454)
- Division of Chemical, Bioengineering, Environmental, and Transport Systems (1705852)
- National Science Foundation
- National Institutes of Health
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